SND1

Staphylococcal nuclease and tudor domain containing 1

PDB rendering based on 2hqx.
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols SND1 ; TDRD11; p100
External IDs OMIM: 602181 MGI: 1929266 HomoloGene: 8665 GeneCards: SND1 Gene
Orthologs
Species Human Mouse
Entrez 27044 56463
Ensembl ENSG00000197157 ENSMUSG00000001424
UniProt Q7KZF4 Q78PY7
RefSeq (mRNA) NM_014390 NM_019776
RefSeq (protein) NP_055205 NP_062750
Location (UCSC) Chr 7:
127.65 – 128.09 Mb		 Chr 6:
28.48 – 28.94 Mb
PubMed search

Staphylococcal nuclease domain-containing protein 1 also known as 100 kDa coactivator or Tudor domain-containing protein 11 (TDRD11) is a protein that in humans is encoded by the SND1 gene.[1][2][3][4] SND1 is a main component of RISC complex[5] and plays an important role in miRNA function.[6][7] SND1 is Tudor Domain containing protein and Tudor Proteins are highly conserved proteins and even present in Drosophila melanogaster.[8] SND1 is also involved in Autism.[9]

Clinical significance

SND1 acts as oncogene in many cancers[10][11][12] and in hepatocellular carcinoma progression.[6][7] SND1 promotes tumor angiogenesis in human hepatocellular carcinoma through a novel pathway which involves NF-kappaB and miR-221.[13] SND1 promotes migration and invasion via angiotensin II type 1 receptor and TGFβ signaling.[14] SND1 expression is regulated by Mir-184 in gliomas.[15]

Interactions

SND1 has been shown to interact with MYB,[16]

SND1 also interacts with G3BP (stress granule protein)[21] and AEG-1.[6][7]

References

  1. ↑ Tong X, Drapkin R, Yalamanchili R, Mosialos G, Kieff E (Sep 1995). "The Epstein-Barr virus nuclear protein 2 acidic domain forms a complex with a novel cellular coactivator that can interact with TFIIE". Molecular and Cellular Biology 15 (9): 4735–44. doi:10.1128/mcb.15.9.4735. PMC 230717. PMID 7651391.
  2. ↑ Callebaut I, Mornon JP (Jan 1997). "The human EBNA-2 coactivator p100: multidomain organization and relationship to the staphylococcal nuclease fold and to the tudor protein involved in Drosophila melanogaster development". The Biochemical Journal 321 (1): 125–32. doi:10.1042/bj3210125. PMC 1218045. PMID 9003410.
  3. ↑ Paukku K, Yang J, Silvennoinen O (Sep 2003). "Tudor and nuclease-like domains containing protein p100 function as coactivators for signal transducer and activator of transcription 5". Molecular Endocrinology 17 (9): 1805–14. doi:10.1210/me.2002-0256. PMID 12819296.
  4. ↑ "Entrez Gene: SND1 staphylococcal nuclease and tudor domain containing 1".
  5. ↑ Tsuchiya N, Ochiai M, Nakashima K, Ubagai T, Sugimura T, Nakagama H (Oct 2007). "SND1, a component of RNA-induced silencing complex, is up-regulated in human colon cancers and implicated in early stage colon carcinogenesis". Cancer Research 67 (19): 9568–76. doi:10.1158/0008-5472.CAN-06-2707. PMID 17909068.
  6. 1 2 3 Yoo BK, Santhekadur PK, Gredler R, Chen D, Emdad L, Bhutia S, Pannell L, Fisher PB, Sarkar D (May 2011). "Increased RNA-induced silencing complex (RISC) activity contributes to hepatocellular carcinoma". Hepatology 53 (5): 1538–48. doi:10.1002/hep.24216. PMC 3081619. PMID 21520169.
  7. 1 2 3 Yoo BK, Emdad L, Lee SG, Su ZZ, Santhekadur P, Chen D, Gredler R, Fisher PB, Sarkar D (Apr 2011). "Astrocyte elevated gene-1 (AEG-1): A multifunctional regulator of normal and abnormal physiology". Pharmacology & Therapeutics 130 (1): 1–8. doi:10.1016/j.pharmthera.2011.01.008. PMC 3043119. PMID 21256156.
  8. ↑ Ying, Muying; Chen, Dahua (1 January 2012). "Tudor domain-containing proteins of Drosophila melanogaster". Development, Growth & Differentiation 54 (1): 32–43. doi:10.1111/j.1440-169X.2011.01308.x.
  9. ↑ Holt R, Barnby G, Maestrini E, Bacchelli E, Brocklebank D, Sousa I, Mulder EJ, Kantojärvi K, Järvelä I, Klauck SM, Poustka F, Bailey AJ, Monaco AP (Sep 2010). "Linkage and candidate gene studies of autism spectrum disorders in European populations". European Journal of Human Genetics 18 (9): 1013–9. doi:10.1038/ejhg.2010.69. PMC 2987412. PMID 20442744.
  10. ↑ Tsuchiya N, Nakagama H (Nov 2010). "MicroRNA, SND1, and alterations in translational regulation in colon carcinogenesis". Mutation Research 693 (1-2): 94–100. doi:10.1016/j.mrfmmm.2010.09.001. PMID 20883704.
  11. ↑ Kuruma H, Kamata Y, Takahashi H, Igarashi K, Kimura T, Miki K, Miki J, Sasaki H, Hayashi N, Egawa S (Jun 2009). "Staphylococcal nuclease domain-containing protein 1 as a potential tissue marker for prostate cancer". The American Journal of Pathology 174 (6): 2044–50. doi:10.2353/ajpath.2009.080776. PMC 2684170. PMID 19435788.
  12. ↑ Ho J, Kong JW, Choong LY, Loh MC, Toy W, Chong PK, Wong CH, Wong CY, Shah N, Lim YP (Feb 2009). "Novel breast cancer metastasis-associated proteins". Journal of Proteome Research 8 (2): 583–94. doi:10.1021/pr8007368. PMID 19086899.
  13. ↑ Santhekadur PK, Das SK, Gredler R, Chen D, Srivastava J, Robertson C, Baldwin AS, Fisher PB, Sarkar D (Apr 2012). "Multifunction protein staphylococcal nuclease domain containing 1 (SND1) promotes tumor angiogenesis in human hepatocellular carcinoma through novel pathway that involves nuclear factor κB and miR-221". The Journal of Biological Chemistry 287 (17): 13952–8. doi:10.1074/jbc.M111.321646. PMC 3340184. PMID 22396537.
  14. ↑ Santhekadur PK, Akiel M, Emdad L, Gredler R, Srivastava J, Rajasekaran D, Robertson CL, Mukhopadhyay ND, Fisher PB, Sarkar D (2014). "Staphylococcal nuclease domain containing-1 (SND1) promotes migration and invasion via angiotensin II type 1 receptor (AT1R) and TGFβ signaling". FEBS Open Bio 4: 353–61. doi:10.1016/j.fob.2014.03.012. PMID 24918049.
  15. ↑ Emdad L, Janjic A, Alzubi MA, Hu B, Santhekadur PK, Menezes ME, Shen XN, Das SK, Sarkar D, Fisher PB (Mar 2015). "Suppression of miR-184 in malignant gliomas upregulates SND1 and promotes tumor aggressiveness". Neuro-Oncology 17 (3): 419–29. doi:10.1093/neuonc/nou220. PMID 25216670.
  16. ↑ Dash AB, Orrico FC, Ness SA (Aug 1996). "The EVES motif mediates both intermolecular and intramolecular regulation of c-Myb". Genes & Development 10 (15): 1858–69. doi:10.1101/gad.10.15.1858. PMID 8756344.
  17. ↑ Leverson JD, Koskinen PJ, Orrico FC, Rainio EM, Jalkanen KJ, Dash AB, Eisenman RN, Ness SA (Oct 1998). "Pim-1 kinase and p100 cooperate to enhance c-Myb activity". Molecular Cell 2 (4): 417–25. doi:10.1016/S1097-2765(00)80141-0. PMID 9809063.
  18. 1 2 Yang J, Aittomäki S, Pesu M, Carter K, Saarinen J, Kalkkinen N, Kieff E, Silvennoinen O (Sep 2002). "Identification of p100 as a coactivator for STAT6 that bridges STAT6 with RNA polymerase II". The EMBO Journal 21 (18): 4950–8. doi:10.1093/emboj/cdf463. PMC 126276. PMID 12234934.
  19. ↑ Zhou S, Fujimuro M, Hsieh JJ, Chen L, Hayward SD (Feb 2000). "A role for SKIP in EBNA2 activation of CBF1-repressed promoters". Journal of Virology 74 (4): 1939–47. doi:10.1128/jvi.74.4.1939-1947.2000. PMC 111672. PMID 10644367.
  20. ↑ Hsieh JJ, Zhou S, Chen L, Young DB, Hayward SD (Jan 1999). "CIR, a corepressor linking the DNA binding factor CBF1 to the histone deacetylase complex". Proceedings of the National Academy of Sciences of the United States of America 96 (1): 23–8. doi:10.1073/pnas.96.1.23. PMC 15086. PMID 9874765.
  21. ↑ Gao X, Ge L, Shao J, Su C, Zhao H, Saarikettu J, Yao X, Yao Z, Silvennoinen O, Yang J (Aug 2010). "Tudor-SN interacts with and co-localizes with G3BP in stress granules under stress conditions". FEBS Letters 584 (16): 3525–32. doi:10.1016/j.febslet.2010.07.022. PMID 20643132.

Further reading

  • Dash AB, Orrico FC, Ness SA (Aug 1996). "The EVES motif mediates both intermolecular and intramolecular regulation of c-Myb". Genes & Development 10 (15): 1858–69. doi:10.1101/gad.10.15.1858. PMID 8756344. 
  • Leverson JD, Koskinen PJ, Orrico FC, Rainio EM, Jalkanen KJ, Dash AB, Eisenman RN, Ness SA (Oct 1998). "Pim-1 kinase and p100 cooperate to enhance c-Myb activity". Molecular Cell 2 (4): 417–25. doi:10.1016/S1097-2765(00)80141-0. PMID 9809063. 
  • Liénard P, Rivière M, Van Vooren P, Szpirer C, Szpirer J (2001). "Assignment of SND1, the gene encoding coactivator p100, to human chromosome 7q31.3 and rat chromosome 4q23 by in situ hybridization". Cytogenetics and Cell Genetics 90 (3-4): 253–4. doi:10.1159/000056783. PMID 11124528. 
  • Rushton JJ, Ness SA (2001). "The conserved DNA binding domain mediates similar regulatory interactions for A-Myb, B-Myb, and c-Myb transcription factors". Blood Cells, Molecules & Diseases 27 (2): 459–63. doi:10.1006/bcmd.2001.0405. PMID 11259168. 
  • Broadhurst MK, Wheeler TT (Nov 2001). "The p100 coactivator is present in the nuclei of mammary epithelial cells and its abundance is increased in response to prolactin in culture and in mammary tissue during lactation". The Journal of Endocrinology 171 (2): 329–37. doi:10.1677/joe.0.1710329. PMID 11691653. 
  • Yang J, Aittomäki S, Pesu M, Carter K, Saarinen J, Kalkkinen N, Kieff E, Silvennoinen O (Sep 2002). "Identification of p100 as a coactivator for STAT6 that bridges STAT6 with RNA polymerase II". The EMBO Journal 21 (18): 4950–8. doi:10.1093/emboj/cdf463. PMC 126276. PMID 12234934. 
  • Tijms MA, Snijder EJ (Sep 2003). "Equine arteritis virus non-structural protein 1, an essential factor for viral subgenomic mRNA synthesis, interacts with the cellular transcription co-factor p100". The Journal of General Virology 84 (Pt 9): 2317–22. doi:10.1099/vir.0.19297-0. PMID 12917451. 
  • Rush J, Moritz A, Lee KA, Guo A, Goss VL, Spek EJ, Zhang H, Zha XM, Polakiewicz RD, Comb MJ (Jan 2005). "Immunoaffinity profiling of tyrosine phosphorylation in cancer cells". Nature Biotechnology 23 (1): 94–101. doi:10.1038/nbt1046. PMID 15592455. 
  • Broadhurst MK, Lee RS, Hawkins S, Wheeler TT (Jan 2005). "The p100 EBNA-2 coactivator: a highly conserved protein found in a range of exocrine and endocrine cells and tissues in cattle". Biochimica Et Biophysica Acta 1681 (2-3): 126–33. doi:10.1016/j.bbaexp.2004.10.009. PMID 15627504. 
  • Välineva T, Yang J, Palovuori R, Silvennoinen O (Apr 2005). "The transcriptional co-activator protein p100 recruits histone acetyltransferase activity to STAT6 and mediates interaction between the CREB-binding protein and STAT6". The Journal of Biological Chemistry 280 (15): 14989–96. doi:10.1074/jbc.M410465200. PMID 15695802. 
  • Chi A, Valencia JC, Hu ZZ, Watabe H, Yamaguchi H, Mangini NJ, Huang H, Canfield VA, Cheng KC, Yang F, Abe R, Yamagishi S, Shabanowitz J, Hearing VJ, Wu C, Appella E, Hunt DF (Nov 2006). "Proteomic and bioinformatic characterization of the biogenesis and function of melanosomes". Journal of Proteome Research 5 (11): 3135–44. doi:10.1021/pr060363j. PMID 17081065. 
  • Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M (Nov 2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. 
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