RBPJ

Recombination signal binding protein for immunoglobulin kappa J region
PDB rendering based on 2f8x.
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 2F8X​, 3NBN​, 3V79​
Identifiers
Symbols	RBPJ ; AOS3; CBF1; IGKJRB; IGKJRB1; KBF2; RBP-J; RBPJK; RBPSUH; SUH; csl
External IDs	OMIM: 147183 MGI: 96522 HomoloGene: 7511 GeneCards: RBPJ Gene
Gene ontology Molecular function • recombinase activity • RNA polymerase II core promoter proximal region sequence-specific DNA binding • RNA polymerase II core promoter sequence-specific DNA binding • transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding • RNA polymerase II repressing transcription factor binding • DNA binding • chromatin binding • transcription factor activity, sequence-specific DNA binding • protein binding • transcription factor binding • sequence-specific DNA binding • protein N-terminus binding Cellular component • MAML1-RBP-Jkappa- ICN1 complex • nucleus • nucleoplasm • transcription factor complex • nucleolus • cytoplasm Biological process • negative regulation of transcription from RNA polymerase II promoter • angiogenesis • epithelial to mesenchymal transition • blood vessel remodeling • inflammatory response to antigenic stimulus • secondary heart field specification • outflow tract morphogenesis • endocardium morphogenesis • epithelial to mesenchymal transition involved in endocardial cushion formation • cardiac left ventricle morphogenesis • ventricular trabecula myocardium morphogenesis • regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation • DNA recombination • transcription initiation from RNA polymerase II promoter • humoral immune response • Notch signaling pathway • positive regulation of transcription of Notch receptor target • negative regulation of cell proliferation • auditory receptor cell fate commitment • epidermal cell fate specification • gene expression • pituitary gland development • B cell differentiation • keratinocyte differentiation • negative regulation of ossification • positive regulation of BMP signaling pathway • somatic stem cell maintenance • dorsal aorta morphogenesis • atrioventricular canal development • defense response to bacterium • myeloid dendritic cell differentiation • negative regulation of transcription, DNA-templated • positive regulation of transcription from RNA polymerase II promoter • regulation of timing of cell differentiation • sebaceous gland development • hair follicle maturation • positive regulation of cardiac muscle cell proliferation • Clara cell differentiation • labyrinthine layer blood vessel development • arterial endothelial cell fate commitment • Notch signaling involved in heart development • positive regulation of transcription from RNA polymerase II promoter in response to hypoxia • blood vessel lumenization • interleukin-4 secretion • blood vessel endothelial cell fate specification • positive regulation of ERBB signaling pathway • positive regulation of ephrin receptor signaling pathway • positive regulation of canonical Wnt signaling pathway involved in cardiac muscle cell fate commitment • positive regulation of cell proliferation involved in heart morphogenesis Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	3516	19664
Ensembl	ENSG00000168214	ENSMUSG00000039191
UniProt	Q06330	P31266
RefSeq (mRNA)	NM_005349	NM_001080927
RefSeq (protein)	NP_005340	NP_001074396
Location (UCSC)	Chr 4: 26.16 – 26.44 Mb	Chr 5: 53.56 – 53.66 Mb
PubMed search

Recombining binding protein suppressor of hairless is a protein that in humans is encoded by the RBPJ gene.^[1][2][3]

RBPJ^[4] also known as CBF1, is the human homolog for the Drosophila gene Suppressor of Hairless. Its promoter region is classically used to demonstrate Notch1 signaling.^[5]

Interactions

RBPJ has been shown to interact with:

• NOTCH1^[6][7]
• NCOR2,^[8][9]
• PCAF,^[10]
• SND1,^[11][12] and
• SNW1.^[11][13]

References

1. Amakawa R, Jing W, Ozawa K, Matsunami N, Hamaguchi Y, Matsuda F, Kawaichi M, Honjo T (Aug 1993). "Human Jk recombination signal binding protein gene (IGKJRB): comparison with its mouse homologue". Genomics 17 (2): 306–15. doi:10.1006/geno.1993.1326. PMID 8406481.
2. Tang X, Saito-Ohara F, Song J, Koga C, Ugai H, Murakami H, Ikeuchi T, Yokoyama KK (Jun 1997). "Assignment of the human gene for KBF2/RBP-Jk to chromosome 9p12-13 and 9q13 by fluorescence in situ hybridization". The Japanese Journal of Human Genetics 42 (2): 337–41. doi:10.1007/BF02766956. PMID 9290259.
3. "Entrez Gene: RBPJ recombination signal binding protein for immunoglobulin kappa J region".
4. "Human Genome Organization: RBPJ Report".
5. Hsieh JJ, Henkel T, Salmon P, Robey E, Peterson MG, Hayward SD (Mar 1996). "Truncated mammalian Notch1 activates CBF1/RBPJk-repressed genes by a mechanism resembling that of Epstein-Barr virus EBNA2". Molecular and Cellular Biology 16 (3): 952–9. doi:10.1128/mcb.16.3.952. PMC 231077. PMID 8622698.
6. Nam Y, Weng AP, Aster JC, Blacklow SC (Jun 2003). "Structural requirements for assembly of the CSL.intracellular Notch1.Mastermind-like 1 transcriptional activation complex". The Journal of Biological Chemistry 278 (23): 21232–9. doi:10.1074/jbc.M301567200. PMID 12644465.
7. Aster JC, Robertson ES, Hasserjian RP, Turner JR, Kieff E, Sklar J (Apr 1997). "Oncogenic forms of NOTCH1 lacking either the primary binding site for RBP-Jkappa or nuclear localization sequences retain the ability to associate with RBP-Jkappa and activate transcription". The Journal of Biological Chemistry 272 (17): 11336–43. doi:10.1074/jbc.272.17.11336. PMID 9111040.
8. Beatus P, Lundkvist J, Oberg C, Pedersen K, Lendahl U (Jun 2001). "The origin of the ankyrin repeat region in Notch intracellular domains is critical for regulation of HES promoter activity". Mechanisms of Development 104 (1-2): 3–20. doi:10.1016/s0925-4773(01)00373-2. PMID 11404076.
9. Zhou S, Hayward SD (Sep 2001). "Nuclear localization of CBF1 is regulated by interactions with the SMRT corepressor complex". Molecular and Cellular Biology 21 (18): 6222–32. doi:10.1128/mcb.21.18.6222-6232.2001. PMC 87339. PMID 11509665.
10. Kurooka H, Honjo T (Jun 2000). "Functional interaction between the mouse notch1 intracellular region and histone acetyltransferases PCAF and GCN5". The Journal of Biological Chemistry 275 (22): 17211–20. doi:10.1074/jbc.M000909200. PMID 10747963.
11. Zhou S, Fujimuro M, Hsieh JJ, Chen L, Hayward SD (Feb 2000). "A role for SKIP in EBNA2 activation of CBF1-repressed promoters". Journal of Virology 74 (4): 1939–47. doi:10.1128/jvi.74.4.1939-1947.2000. PMC 111672. PMID 10644367.
12. Hsieh JJ, Zhou S, Chen L, Young DB, Hayward SD (Jan 1999). "CIR, a corepressor linking the DNA binding factor CBF1 to the histone deacetylase complex". Proceedings of the National Academy of Sciences of the United States of America 96 (1): 23–8. doi:10.1073/pnas.96.1.23. PMC 15086. PMID 9874765.
13. Zhou S, Fujimuro M, Hsieh JJ, Chen L, Miyamoto A, Weinmaster G, Hayward SD (Apr 2000). "SKIP, a CBF1-associated protein, interacts with the ankyrin repeat domain of NotchIC To facilitate NotchIC function". Molecular and Cellular Biology 20 (7): 2400–10. doi:10.1128/mcb.20.7.2400-2410.2000. PMC 85419. PMID 10713164.

Further reading

• Oka C, Kawaichi M (1995). "V(D)J recombination of immunoglobulin genes". Advances in Biophysics 31: 163–80. doi:10.1016/0065-227X(95)99390-B. PMID 7625272.
• Matsunami N, Hamaguchi Y, Yamamoto Y, Kuze K, Kangawa K, Matsuo H, Kawaichi M, Honjo T (1990). "A protein binding to the J kappa recombination sequence of immunoglobulin genes contains a sequence related to the integrase motif". Nature 342 (6252): 934–7. doi:10.1038/342934a0. PMID 2556644.
• Tong X, Drapkin R, Yalamanchili R, Mosialos G, Kieff E (Sep 1995). "The Epstein-Barr virus nuclear protein 2 acidic domain forms a complex with a novel cellular coactivator that can interact with TFIIE". Molecular and Cellular Biology 15 (9): 4735–44. doi:10.1128/mcb.15.9.4735. PMC 230717. PMID 7651391.
• Zhao B, Marshall DR, Sample CE (Jul 1996). "A conserved domain of the Epstein-Barr virus nuclear antigens 3A and 3C binds to a discrete domain of Jkappa". Journal of Virology 70 (7): 4228–36. PMC 190353. PMID 8676443.
• Tamura K, Taniguchi Y, Minoguchi S, Sakai T, Tun T, Furukawa T, Honjo T (Dec 1995). "Physical interaction between a novel domain of the receptor Notch and the transcription factor RBP-J kappa/Su(H)". Current Biology 5 (12): 1416–23. doi:10.1016/S0960-9822(95)00279-X. PMID 8749394.
• Gress TM, Müller-Pillasch F, Geng M, Zimmerhackl F, Zehetner G, Friess H, Büchler M, Adler G, Lehrach H (Oct 1996). "A pancreatic cancer-specific expression profile". Oncogene 13 (8): 1819–30. PMID 8895530.
• Hsieh JJ, Nofziger DE, Weinmaster G, Hayward SD (Mar 1997). "Epstein-Barr virus immortalization: Notch2 interacts with CBF1 and blocks differentiation". Journal of Virology 71 (3): 1938–45. PMC 191274. PMID 9032325.
• Aster JC, Robertson ES, Hasserjian RP, Turner JR, Kieff E, Sklar J (Apr 1997). "Oncogenic forms of NOTCH1 lacking either the primary binding site for RBP-Jkappa or nuclear localization sequences retain the ability to associate with RBP-Jkappa and activate transcription". The Journal of Biological Chemistry 272 (17): 11336–43. doi:10.1074/jbc.272.17.11336. PMID 9111040.
• Kao HY, Ordentlich P, Koyano-Nakagawa N, Tang Z, Downes M, Kintner CR, Evans RM, Kadesch T (Aug 1998). "A histone deacetylase corepressor complex regulates the Notch signal transduction pathway". Genes & Development 12 (15): 2269–77. doi:10.1101/gad.12.15.2269. PMC 317043. PMID 9694793.
• Hsieh JJ, Zhou S, Chen L, Young DB, Hayward SD (Jan 1999). "CIR, a corepressor linking the DNA binding factor CBF1 to the histone deacetylase complex". Proceedings of the National Academy of Sciences of the United States of America 96 (1): 23–8. doi:10.1073/pnas.96.1.23. PMC 15086. PMID 9874765.
• Scanlan MJ, Gordan JD, Williamson B, Stockert E, Bander NH, Jongeneel V, Gure AO, Jäger D, Jäger E, Knuth A, Chen YT, Old LJ (Nov 1999). "Antigens recognized by autologous antibody in patients with renal-cell carcinoma". International Journal of Cancer. Journal International Du Cancer 83 (4): 456–64. doi:10.1002/(SICI)1097-0215(19991112)83:4<456::AID-IJC4>3.0.CO;2-5. PMID 10508479.
• Callahan J, Aster J, Sklar J, Kieff E, Robertson ES (Jan 2000). "Intracellular forms of human NOTCH1 interact at distinctly different levels with RBP-jkappa in human B and T cells". Leukemia 14 (1): 84–92. doi:10.1038/sj.leu.2401630. PMID 10637481.
• Smith PR, de Jesus O, Turner D, Hollyoake M, Karstegl CE, Griffin BE, Karran L, Wang Y, Hayward SD, Farrell PJ (Apr 2000). "Structure and coding content of CST (BART) family RNAs of Epstein-Barr virus". Journal of Virology 74 (7): 3082–92. doi:10.1128/JVI.74.7.3082-3092.2000. PMC 111807. PMID 10708423.
• Zhou S, Fujimuro M, Hsieh JJ, Chen L, Miyamoto A, Weinmaster G, Hayward SD (Apr 2000). "SKIP, a CBF1-associated protein, interacts with the ankyrin repeat domain of NotchIC To facilitate NotchIC function". Molecular and Cellular Biology 20 (7): 2400–10. doi:10.1128/MCB.20.7.2400-2410.2000. PMC 85419. PMID 10713164.
• Kurooka H, Honjo T (Jun 2000). "Functional interaction between the mouse notch1 intracellular region and histone acetyltransferases PCAF and GCN5". The Journal of Biological Chemistry 275 (22): 17211–20. doi:10.1074/jbc.M000909200. PMID 10747963.
• Beatus P, Lundkvist J, Oberg C, Pedersen K, Lendahl U (Jun 2001). "The origin of the ankyrin repeat region in Notch intracellular domains is critical for regulation of HES promoter activity". Mechanisms of Development 104 (1-2): 3–20. doi:10.1016/S0925-4773(01)00373-2. PMID 11404076.
• Zhou S, Hayward SD (Sep 2001). "Nuclear localization of CBF1 is regulated by interactions with the SMRT corepressor complex". Molecular and Cellular Biology 21 (18): 6222–32. doi:10.1128/MCB.21.18.6222-6232.2001. PMC 87339. PMID 11509665.

External links

• RBPJ protein, human at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.