SOCS2

Suppressor of cytokine signaling 2
PDB rendering based on 2c9w.
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 2C9W​, 4JGH​
Identifiers
Symbols	SOCS2 ; CIS2; Cish2; SOCS-2; SSI-2; SSI2; STATI2
External IDs	OMIM: 605117 MGI: 1201787 HomoloGene: 2880 GeneCards: SOCS2 Gene
Gene ontology Molecular function • protein kinase inhibitor activity • SH3/SH2 adaptor activity • growth hormone receptor binding • insulin-like growth factor receptor binding • protein binding • JAK pathway signal transduction adaptor activity Cellular component • cytoplasm • cytosol Biological process • regulation of cell growth • negative regulation of protein kinase activity • JAK-STAT cascade • aging • regulation of signal transduction • positive regulation of signal transduction • protein ubiquitination • cytokine-mediated signaling pathway • response to estradiol • cellular response to hormone stimulus • negative regulation of apoptotic process • negative regulation of JAK-STAT cascade • negative regulation of insulin receptor signaling pathway • growth hormone receptor signaling pathway • JAK-STAT cascade involved in growth hormone signaling pathway • negative regulation of cyclin-dependent protein kinase activity Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	8835	216233
Ensembl	ENSG00000120833	ENSMUSG00000020027
UniProt	O14508	O35717
RefSeq (mRNA)	NM_001270467	NM_001168655
RefSeq (protein)	NP_001257396	NP_001162126
Location (UCSC)	Chr 12: 93.57 – 93.58 Mb	Chr 10: 95.39 – 95.42 Mb
PubMed search

Suppressor of cytokine signaling 2 is a protein that in humans is encoded by the SOCS2 gene.^[1][2][3]

This gene encodes a member of the STAT-induced STAT inhibitor (SSI), also known as suppressor of cytokine signalling (SOCS), family. SSI family members are cytokine-inducible negative regulators of cytokine signaling. The expression of this gene can be induced by a subset of cytokines, including erythropoietin, GM-CSF, IL10 and interferon-gamma (IFN-gamma). The protein encoded by this gene is found to interact with the cytoplasmic domain of insulin-like growth factor 1 receptor (IGF1R), and thus is thought to be involved in the regulation of IGF1R mediated cell signaling.^[4] Knockout studies in mice also suggested a regulatory role of this gene in IGF-1 related growth control.^[3][5]

Interactions

SOCS2 has been shown to interact with Insulin-like growth factor 1 receptor^[4] and Erythropoietin receptor.^[6]

References

1. Masuhara M, Sakamoto H, Matsumoto A, Suzuki R, Yasukawa H, Mitsui K, Wakioka T, Tanimura S, Sasaki A, Misawa H, Yokouchi M, Ohtsubo M, Yoshimura A (November 1997). "Cloning and characterization of novel CIS family genes". Biochem Biophys Res Commun 239 (2): 439–46. doi:10.1006/bbrc.1997.7484. PMID 9344848.
2. Minamoto S, Ikegame K, Ueno K, Narazaki M, Naka T, Yamamoto H, Matsumoto T, Saito H, Hosoe S, Kishimoto T (September 1997). "Cloning and functional analysis of new members of STAT induced STAT inhibitor (SSI) family: SSI-2 and SSI-3". Biochem Biophys Res Commun 237 (1): 79–83. doi:10.1006/bbrc.1997.7080. PMID 9266833.
3. "Entrez Gene: SOCS2 suppressor of cytokine signaling 2".
4. Dey BR, Spence SL, Nissley P, Furlanetto RW (September 1998). "Interaction of human suppressor of cytokine signaling (SOCS)-2 with the insulin-like growth factor-I receptor". J. Biol. Chem. 273 (37): 24095–101. doi:10.1074/jbc.273.37.24095. PMID 9727029.
5. Greenhalgh CJ, Bertolino P, Asa SL, Metcalf D, Corbin JE, Adams TE, Davey HW, Nicola NA, Hilton DJ, Alexander WS (June 2002). "Growth enhancement in suppressor of cytokine signaling 2 (SOCS-2)-deficient mice is dependent on signal transducer and activator of transcription 5b (STAT5b)". Mol. Endocrinol. 16 (6): 1394–406. doi:10.1210/me.16.6.1394. PMID 12040024.
6. Eyckerman, S; Verhee A; der Heyden J V; Lemmens I; Ostade X V; Vandekerckhove J; Tavernier J (Dec 2001). "Design and application of a cytokine-receptor-based interaction trap". Nat. Cell Biol. (England) 3 (12): 1114–9. doi:10.1038/ncb1201-1114. ISSN 1465-7392. PMID 11781573.

Further reading

• Lopaczynski W (1999). "Differential regulation of signaling pathways for insulin and insulin-like growth factor I.". Acta Biochim. Pol. 46 (1): 51–60. PMID 10453981.
• Wang J, Campbell IL (2002). "Cytokine signaling in the brain: putting a SOCS in it?". J. Neurosci. Res. 67 (4): 423–7. doi:10.1002/jnr.10145. PMID 11835308.
• Kile BT, Schulman BA, Alexander WS, et al. (2002). "The SOCS box: a tale of destruction and degradation.". Trends Biochem. Sci. 27 (5): 235–41. doi:10.1016/S0968-0004(02)02085-6. PMID 12076535.
• Pezet A, Buteau H, Kelly PA, Edery M (1997). "The last proline of Box 1 is essential for association with JAK2 and functional activation of the prolactin receptor.". Mol. Cell. Endocrinol. 129 (2): 199–208. doi:10.1016/S0303-7207(97)00063-4. PMID 9202403.
• Dey BR, Spence SL, Nissley P, Furlanetto RW (1998). "Interaction of human suppressor of cytokine signaling (SOCS)-2 with the insulin-like growth factor-I receptor.". J. Biol. Chem. 273 (37): 24095–101. doi:10.1074/jbc.273.37.24095. PMID 9727029.
• Pezet A, Favre H, Kelly PA, Edery M (1999). "Inhibition and restoration of prolactin signal transduction by suppressors of cytokine signaling.". J. Biol. Chem. 274 (35): 24497–502. doi:10.1074/jbc.274.35.24497. PMID 10455112.
• Yandava CN, Pillari A, Drazen JM (1999). "Radiation hybrid and cytogenetic mapping of SOCS1 and SOCS2 to chromosomes 16p13 and 12q, respectively.". Genomics 61 (1): 108–11. doi:10.1006/geno.1999.5937. PMID 10512686.
• Ram PA, Waxman DJ (2000). "SOCS/CIS protein inhibition of growth hormone-stimulated STAT5 signaling by multiple mechanisms.". J. Biol. Chem. 274 (50): 35553–61. doi:10.1074/jbc.274.50.35553. PMID 10585430.
• Metcalf D, Greenhalgh CJ, Viney E, et al. (2000). "Gigantism in mice lacking suppressor of cytokine signalling-2.". Nature 405 (6790): 1069–73. doi:10.1038/35016611. PMID 10890450.
• Shen X, Hong F, Nguyen VA, Gao B (2000). "IL-10 attenuates IFN-alpha-activated STAT1 in the liver: involvement of SOCS2 and SOCS3.". FEBS Lett. 480 (2-3): 132–6. doi:10.1016/S0014-5793(00)01905-0. PMID 11034314.
• Eyckerman S, Verhee A, der Heyden JV, et al. (2002). "Design and application of a cytokine-receptor-based interaction trap.". Nat. Cell Biol. 3 (12): 1114–9. doi:10.1038/ncb1201-1114. PMID 11781573.
• Schultheis B, Carapeti-Marootian M, Hochhaus A, et al. (2002). "Overexpression of SOCS-2 in advanced stages of chronic myeloid leukemia: possible inadequacy of a negative feedback mechanism.". Blood 99 (5): 1766–75. doi:10.1182/blood.V99.5.1766. PMID 11861294.
• Blumenstein M, Bowen-Shauver JM, Keelan JA, Mitchell MD (2002). "Identification of suppressors of cytokine signaling (SOCS) proteins in human gestational tissues: differential regulation is associated with the onset of labor.". J. Clin. Endocrinol. Metab. 87 (3): 1094–7. doi:10.1210/jc.87.3.1094. PMID 11889171.
• Biener E, Maurice S, Sandowski Y, et al. (2003). "Recombinant human CIS2 (SOCS2) protein: subcloning, expression, purification, and characterization.". Protein Expr. Purif. 25 (2): 305–12. doi:10.1016/S1046-5928(02)00013-X. PMID 12135564.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.

External links

• SOCS2 protein, human at the US National Library of Medicine Medical Subject Headings (MeSH)