SRI (gene)

Sorcin
PDB rendering based on 1gjy.
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 1JUO​, 2JC2​, 4UPG​
Identifiers
Symbols	SRI ; CP-22; CP22; SCN; V19
External IDs	OMIM: 182520 MGI: 98419 HomoloGene: 37736 GeneCards: SRI Gene
Gene ontology Molecular function • protease binding • calcium-dependent cysteine-type endopeptidase activity • receptor binding • calcium channel regulator activity • calcium ion binding • protein binding • identical protein binding • ion channel binding • protein heterodimerization activity • repressing transcription factor binding Cellular component • nucleoplasm • cytoplasm • mitochondrion • endoplasmic reticulum membrane • smooth endoplasmic reticulum • cytosol • membrane • sarcoplasmic reticulum • Z disc • T-tubule • sarcoplasmic reticulum membrane • chromaffin granule membrane • axon terminus • dendritic spine neck • extracellular exosome Biological process • action potential • proteolysis • transport • calcium ion transport • intracellular sequestering of iron ion • regulation of striated muscle contraction • signal transduction • heart development • muscle organ development • regulation of heart contraction • negative regulation of heart rate • regulation of cell communication by electrical coupling • regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum • positive regulation of insulin secretion involved in cellular response to glucose stimulus • cytoplasmic sequestering of transcription factor • positive regulation of release of sequestered calcium ion into cytosol • regulation of calcium ion transport • negative regulation of ryanodine-sensitive calcium-release channel activity • regulation of cardiac muscle cell contraction • regulation of relaxation of muscle • regulation of high voltage-gated calcium channel activity • regulation of cell communication by electrical coupling involved in cardiac conduction • negative regulation of transcription regulatory region DNA binding Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	6717	109552
Ensembl	ENSG00000075142	ENSMUSG00000003161
UniProt	P30626	Q6P069
RefSeq (mRNA)	NM_001256891	NM_001080974
RefSeq (protein)	NP_001243820	NP_001074443
Location (UCSC)	Chr 7: 88.21 – 88.23 Mb	Chr 5: 8.05 – 8.07 Mb
PubMed search

Sorcin is a protein that in humans is encoded by the SRI gene.^[1][2]

Interactions

SRI (gene) has been shown to interact with Ryanodine receptor 2,^[3] ANXA7^[4] and GCA.^[5]

References

1. Van der Bliek AM, Baas F, Van der Velde-Koerts T, Biedler JL, Meyers MB, Ozols RF, Hamilton TC, Joenje H, Borst P (Nov 1988). "Genes amplified and overexpressed in human multidrug-resistant cell lines". Cancer Res 48 (21): 5927–32. PMID 2901906.
2. "Entrez Gene: SRI sorcin".
3. Meyers, M B; Pickel V M; Sheu S S; Sharma V K; Scotto K W; Fishman G I (Nov 1995). "Association of sorcin with the cardiac ryanodine receptor". J. Biol. Chem. (UNITED STATES) 270 (44): 26411–8. doi:10.1074/jbc.270.44.26411. ISSN 0021-9258. PMID 7592856.
4. Brownawell, A M; Creutz C E (Aug 1997). "Calcium-dependent binding of sorcin to the N-terminal domain of synexin (annexin VII)". J. Biol. Chem. (UNITED STATES) 272 (35): 22182–90. doi:10.1074/jbc.272.35.22182. ISSN 0021-9258. PMID 9268363.
5. Hansen, Christian; Tarabykina Svetlana; la Cour Jonas M; Lollike Karsten; Berchtold Martin W (Jun 2003). "The PEF family proteins sorcin and grancalcin interact in vivo and in vitro". FEBS Lett. (Netherlands) 545 (2–3): 151–4. doi:10.1016/S0014-5793(03)00518-0. ISSN 0014-5793. PMID 12804766.

Further reading

• Rasmussen HH, van Damme J, Puype M, et al. (1993). "Microsequences of 145 proteins recorded in the two-dimensional gel protein database of normal human epidermal keratinocytes". Electrophoresis 13 (12): 960–9. doi:10.1002/elps.11501301199. PMID 1286667.
• Meyers MB, Pickel VM, Sheu SS, et al. (1995). "Association of sorcin with the cardiac ryanodine receptor". J. Biol. Chem. 270 (44): 26411–8. doi:10.1074/jbc.270.44.26411. PMID 7592856.
• Meyers MB, Zamparelli C, Verzili D, et al. (1995). "Calcium-dependent translocation of sorcin to membranes: functional relevance in contractile tissue". FEBS Lett. 357 (3): 230–4. doi:10.1016/0014-5793(94)01338-2. PMID 7835417.
• Wang SL, Tam MF, Ho YS, et al. (1995). "Isolation and molecular cloning of human sorcin a calcium-binding protein in vincristine-resistant HOB1 lymphoma cells". Biochim. Biophys. Acta 1260 (3): 285–93. doi:10.1016/0167-4781(94)00206-i. PMID 7873602.
• Lee WP (1996). "Purification, cDNA cloning, and expression of human sorcin in vincristine-resistant HOB1 lymphoma cell lines". Arch. Biochem. Biophys. 325 (2): 217–26. doi:10.1006/abbi.1996.0027. PMID 8561500.
• Brownawell AM, Creutz CE (1997). "Calcium-dependent binding of sorcin to the N-terminal domain of synexin (annexin VII)". J. Biol. Chem. 272 (35): 22182–90. doi:10.1074/jbc.272.35.22182. PMID 9268363.
• Torigoe K, Harada T, Kusaba H, et al. (1998). "Localization of 67 exons on a YAC contig spanning 1.5 Mb around the multidrug resistance gene region of human chromosome 7q21.1". Genomics 49 (1): 14–22. doi:10.1006/geno.1997.5200. PMID 9570944.
• Meyers MB, Puri TS, Chien AJ, et al. (1998). "Sorcin associates with the pore-forming subunit of voltage-dependent L-type Ca2+ channels". J. Biol. Chem. 273 (30): 18930–5. doi:10.1074/jbc.273.30.18930. PMID 9668070.
• Pack-Chung E, Meyers MB, Pettingell WP, et al. (2000). "Presenilin 2 interacts with sorcin, a modulator of the ryanodine receptor". J. Biol. Chem. 275 (19): 14440–5. doi:10.1074/jbc.M909882199. PMID 10748169.
• Xie X, Dwyer MD, Swenson L, et al. (2002). "Crystal structure of calcium-free human sorcin: A member of the penta-EF-hand protein family". Protein Sci. 10 (12): 2419–25. doi:10.1110/ps.ps.36701. PMC 2374028. PMID 11714909.
• Li G, Tan Y, Yang C, et al. (2003). "Expression and clinical implication of soluble resistance-associated calcium-binding protein gene and multi-drug resistance gene in leukemia". Zhonghua Zhong Liu Za Zhi 24 (4): 370–4. PMID 12408767.
• Li G, Tan Y, Yang C, et al. (2002). "Expression and clinical implications of the soluble drug resistance-related calcium-binding protein (sorcin) gene in leukemia patients". Zhonghua Xue Ye Xue Za Zhi 23 (6): 293–6. PMID 12411058.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Meyers MB, Fischer A, Sun YJ, et al. (2003). "Sorcin regulates excitation-contraction coupling in the heart". J. Biol. Chem. 278 (31): 28865–71. doi:10.1074/jbc.M302009200. PMID 12754254.
• Hansen C, Tarabykina S, la Cour JM, et al. (2003). "The PEF family proteins sorcin and grancalcin interact in vivo and in vitro". FEBS Lett. 545 (2–3): 151–4. doi:10.1016/S0014-5793(03)00518-0. PMID 12804766.
• Colland F, Jacq X, Trouplin V, et al. (2004). "Functional Proteomics Mapping of a Human Signaling Pathway". Genome Res. 14 (7): 1324–32. doi:10.1101/gr.2334104. PMC 442148. PMID 15231748.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Frank KF, Bölck B, Ding Z, et al. (2005). "Overexpression of sorcin enhances cardiac contractility in vivo and in vitro". J. Mol. Cell. Cardiol. 38 (4): 607–15. doi:10.1016/j.yjmcc.2005.01.011. PMID 15808837.
• Pope SN, Lee IR (2005). "Yeast two-hybrid identification of prostatic proteins interacting with human sex hormone-binding globulin". J. Steroid Biochem. Mol. Biol. 94 (1–3): 203–8. doi:10.1016/j.jsbmb.2005.01.007. PMID 15862967.