Sulfoxaflor

Sulfoxaflor
Names
IUPAC name
[Methyl(oxo){1-[6-(trifluoromethyl)-3-pyridyl]ethyl}-λ6-sulfanylidene]cyanamide
Identifiers
946578-00-3 YesY
Properties
C10H10F3N3OS
Molar mass 277.27 g·mol−1
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
Infobox references

Sulfoxaflor is a systemic insecticide which acts as an insect neurotoxin and is a member a class of chemicals called sulfoximines which act on the central nervous system of insects.

Mode of action

Sulfoxaflor is classified for use against sap-feeding insects as a sulfoximine, which is a sub-group of insecticides that act as nicotinic acetylcholine receptor (nAChR) competitive modulators.[1][2] Sulfoxaflor binds to nAChRs in place of acetylcholine. Sulfoxaflor binding causes uncontrolled nerve impulses resulting in muscle tremors followed by paralysis and death.[1]

Other nAChR competitive modulator sub-groups that bind differently on the receptor than sulfoximines include neonicotinoids, nicotine, and butenolides.[3][1][4]

Because sulfoxaflor binds much more strongly to insect neuron receptors than to mammal neuron receptors, this insecticide is selectively more toxic to insects than mammals.[5]

Non-target effects

Application is only recommended when pollinators are not likely to be present in an area as sulfoxaflor is highly toxic to bees if they come into contact with spray droplets shortly after application; toxicity is reduced after the spray has dried. [2]

Registration

On May 6, 2013, the United States Environmental Protection Agency (EPA) approved the first two commercial pesticide products that contain sulfoxaflor, marketed under the brand names "Transform" and "Closer", to the Dow Chemical Corporation. This pesticide has been registered in South Korea, Panama, Vietnam, Indonesia and Guatemala.

On September 10, 2015 the U.S. 9th Circuit Court of Appeals overturned the EPA's approval of sulfoxaflor, citing insufficient evidence from studies regarding bee health to justify how sulfoxaflor was approved.[6][4] Beekeepers and environmental groups supported the decision, saying that the EPA must assess the health of entire hives, not just individual bees.[7]

See also

References

  1. 1 2 3 Casida, J.E.; Durkin, K.A. (2013). "Neuroactive insecticides: targets, selectivity, resistance, and secondary Effects". Annual Review of Entomology 58: 99–117. doi:10.1146/annurev-ento-120811-153645.
  2. 1 2 "Sulfoxaflor" (PDF).
  3. "IRAC Mode of Action Classification Scheme".
  4. 1 2 "Court rejects US approval of sulfoxaflor pesticide". Royal Society of Chemistry. 2015-09-16. Retrieved 2015-09-17.
  5. Tomizawa, M.; Casida, J.E. (2003). "Selective toxicity of neonicotinoids attributable to specificity of insect and mammalian nicotinic receptors". Annual Review of Entomology 48: 339–64. doi:10.1146/annurev.ento.48.091801.112731.
  6. "Court revokes approval of insecticide, citing 'alarming' decline in bees". LA Times. 2015-09-10. Retrieved 2015-09-14.
  7. Philpott, Tom (11 September 2015). "Federal Court to EPA: No, You Can’t Approve This Pesticide That Kills Bees". Mother Jones. Retrieved 19 September 2015.

External links

This article is issued from Wikipedia - version of the Saturday, January 16, 2016. The text is available under the Creative Commons Attribution/Share Alike but additional terms may apply for the media files.