TXNDC2

Thioredoxin domain containing 2 (spermatozoa)
Identifiers
Symbols	TXNDC2 ; SPTRX; SPTRX1
External IDs	MGI: 2389312 HomoloGene: 41856 GeneCards: TXNDC2 Gene
Gene ontology Molecular function • thioredoxin-disulfide reductase activity • protein disulfide oxidoreductase activity • oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor Cellular component • outer dense fiber • nucleus • nucleoplasm • nucleolus • cytoplasm • mitochondrion Biological process • sulfate assimilation • protein folding • glycerol ether metabolic process • multicellular organismal development • spermatogenesis • cell differentiation • cellular response to oxidative stress • cell redox homeostasis • oxidation-reduction process Sources: Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	84203	213272
Ensembl	ENSG00000168454	ENSMUSG00000050612
UniProt	Q86VQ3	Q6P902
RefSeq (mRNA)	NM_001098529	NM_001146002
RefSeq (protein)	NP_001091999	NP_001139474
Location (UCSC)	Chr 18: 9.89 – 9.89 Mb	Chr 17: 65.64 – 65.64 Mb
PubMed search

Thioredoxin domain-containing protein 2 is a protein that in humans is encoded by the TXNDC2 gene.^[1][2][3]

References

1. Wiemann S, Weil B, Wellenreuther R, Gassenhuber J, Glassl S, Ansorge W, Bocher M, Blocker H, Bauersachs S, Blum H, Lauber J, Dusterhoft A, Beyer A, Kohrer K, Strack N, Mewes HW, Ottenwalder B, Obermaier B, Tampe J, Heubner D, Wambutt R, Korn B, Klein M, Poustka A (Mar 2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Res 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
2. Miranda-Vizuete A, Ljung J, Damdimopoulos AE, Gustafsson JA, Oko R, Pelto-Huikko M, Spyrou G (Aug 2001). "Characterization of Sptrx, a novel member of the thioredoxin family specifically expressed in human spermatozoa". J Biol Chem 276 (34): 31567–74. doi:10.1074/jbc.M101760200. PMID 11399755.
3. "Entrez Gene: TXNDC2 thioredoxin domain containing 2 (spermatozoa)".

Further reading

• Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Jiménez A, Johansson C, Ljung J, et al. (2002). "Human spermatid-specific thioredoxin-1 (Sptrx-1) is a two-domain protein with oxidizing activity.". FEBS Lett. 530 (1–3): 79–84. doi:10.1016/S0014-5793(02)03417-8. PMID 12387870.
• Sadek CM, Damdimopoulos AE, Pelto-Huikko M, et al. (2002). "Sptrx-2, a fusion protein composed of one thioredoxin and three tandemly repeated NDP-kinase domains is expressed in human testis germ cells". Genes Cells 6 (12): 1077–90. doi:10.1046/j.1365-2443.2001.00484.x. PMID 11737268.