TXNDC5

Thioredoxin domain containing 5 (endoplasmic reticulum)
PDB rendering based on 2diz.
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 2DIZ​, 3UJ1​, 3UVT​, 3WGD​, 3WGE​, 3WGX​
Identifiers
Symbols	TXNDC5 ; ENDOPDI; ERP46; HCC-2; HCC2; PDIA15; STRF8; UNQ364
External IDs	OMIM: 616412 MGI: 2145316 HomoloGene: 11125 GeneCards: TXNDC5 Gene
Gene ontology Molecular function • protein disulfide isomerase activity • protein binding Cellular component • endoplasmic reticulum • endoplasmic reticulum lumen • lysosomal lumen • extracellular exosome Biological process • protein folding • post-Golgi vesicle-mediated transport • response to endoplasmic reticulum stress • negative regulation of apoptotic process • apoptotic cell clearance • cell redox homeostasis • membrane organization Sources: Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	81567	105245
Ensembl	ENSG00000239264	ENSMUSG00000038991
UniProt	Q8NBS9	Q91W90
RefSeq (mRNA)	NM_001145549	NM_001289598
RefSeq (protein)	NP_001139021	NP_001276527
Location (UCSC)	Chr 6: 7.88 – 7.91 Mb	Chr 13: 38.5 – 38.53 Mb
PubMed search

Thioredoxin domain-containing protein 5 is a protein that in humans is encoded by the TXNDC5 gene.^[1]

Function

This gene encodes a protein disulfide-isomerase.^[2] Its expression is induced by hypoxia and its role may be to protect hypoxic cells from apoptosis. This gene can be co-transcribed with the upstream gene MUTED.^[1]

References

1. "Entrez Gene: TXNDC5 thioredoxin domain containing 5".
2. Galligan JJ, Petersen DR (July 2012). "The human protein disulfide isomerase gene family". Human Genomics 6 (6): 6. doi:10.1186/1479-7364-6-6. PMC 3500226. PMID 23245351.

Further reading

• Neve EP, Svensson K, Fuxe J, Pettersson RF (Aug 2003). "VIPL, a VIP36-like membrane protein with a putative function in the export of glycoproteins from the endoplasmic reticulum". Experimental Cell Research 288 (1): 70–83. doi:10.1016/S0014-4827(03)00161-7. PMID 12878160.
• Knoblach B, Keller BO, Groenendyk J, Aldred S, Zheng J, Lemire BD, Li L, Michalak M (Oct 2003). "ERp19 and ERp46, new members of the thioredoxin family of endoplasmic reticulum proteins". Molecular & Cellular Proteomics 2 (10): 1104–19. doi:10.1074/mcp.M300053-MCP200. PMID 12930873.
• Sullivan DC, Huminiecki L, Moore JW, Boyle JJ, Poulsom R, Creamer D, Barker J, Bicknell R (Nov 2003). "EndoPDI, a novel protein-disulfide isomerase-like protein that is preferentially expressed in endothelial cells acts as a stress survival factor". The Journal of Biological Chemistry 278 (47): 47079–88. doi:10.1074/jbc.M308124200. PMID 12963716.
• Bruneel A, Labas V, Mailloux A, Sharma S, Royer N, Vinh J, Pernet P, Vaubourdolle M, Baudin B (Oct 2005). "Proteomics of human umbilical vein endothelial cells applied to etoposide-induced apoptosis". Proteomics 5 (15): 3876–84. doi:10.1002/pmic.200401239. PMID 16130169.
• Nissom PM, Lo SL, Lo JC, Ong PF, Lim JW, Ou K, Liang RC, Seow TK, Chung MC (Apr 2006). "Hcc-2, a novel mammalian ER thioredoxin that is differentially expressed in hepatocellular carcinoma". FEBS Letters 580 (9): 2216–26. doi:10.1016/j.febslet.2006.03.029. PMID 16574106.
• Wang Y, Ma Y, Lü B, Xu E, Huang Q, Lai M (Oct 2007). "Differential expression of mimecan and thioredoxin domain-containing protein 5 in colorectal adenoma and cancer: a proteomic study". Experimental Biology and Medicine 232 (9): 1152–9. doi:10.3181/0701-RM-8. PMID 17895523.