Translin-associated factor X

Translin-associated factor X
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 3PJA​, 3QB5​
Identifiers
Symbols	TSNAX ; TRAX
External IDs	OMIM: 602964 MGI: 1855672 HomoloGene: 4374 GeneCards: TSNAX Gene
Gene ontology Molecular function • DNA binding • single-stranded DNA binding • endoribonuclease activity • protein binding • protein transporter activity • sequence-specific DNA binding • poly(A) RNA binding • metal ion binding Cellular component • nucleus • cytoplasm • Golgi apparatus • cytosol • perinuclear region of cytoplasm Biological process • multicellular organismal development • spermatogenesis • gene expression • protein transport • cell differentiation • RNA phosphodiester bond hydrolysis, endonucleolytic Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	7257	53424
Ensembl	ENSG00000116918	ENSMUSG00000056820
UniProt	Q99598	Q9QZE7
RefSeq (mRNA)	NM_005999	NM_016909
RefSeq (protein)	NP_005990	NP_058605
Location (UCSC)	Chr 1: 231.53 – 231.57 Mb	Chr 8: 125.01 – 125.03 Mb
PubMed search

Translin-associated protein X (abbr. TSNAX or TRAX) is a protein that in humans is encoded by the TSNAX gene.^[1][2]

Function

This gene encodes a protein which specifically interacts with translin, a DNA-binding protein that binds consensus sequences at breakpoint junctions of chromosomal translocations. The encoded protein contains bipartite nuclear targeting sequences that may provide nuclear transport for translin, which lacks any nuclear targeting motifs.^[2] Both TSNAX and translin form the C3PO complex which facilitates endonucleolytic cleavage of the passenger strand during microRNA loading into the RNA-induced silencing complex (RISC).^[3]

Interactions

TSNAX has been shown to interact with C1D.^[4]

References

1. Aoki K, Ishida R, Kasai M (Jan 1997). "Isolation and characterization of a cDNA encoding a Translin-like protein, TRAX". FEBS Letters 401 (2-3): 109–12. doi:10.1016/S0014-5793(96)01444-5. PMID 9013868.
2. "Entrez Gene: TSNAX translin-associated factor X".
3. Ha M, Kim VN (Aug 2014). "Regulation of microRNA biogenesis". Nature Reviews Molecular Cell Biology 15 (8): 509–24. doi:10.1038/nrm3838. PMID 25027649.
4. Erdemir T, Bilican B, Oncel D, Goding CR, Yavuzer U (Jan 2002). "DNA damage-dependent interaction of the nuclear matrix protein C1D with Translin-associated factor X (TRAX)". Journal of Cell Science 115 (Pt 1): 207–16. PMID 11801738.

Further reading

• Millar JK, Christie S, Semple CA, Porteous DJ (Jul 2000). "Chromosomal location and genomic structure of the human translin-associated factor X gene (TRAX; TSNAX) revealed by intergenic splicing to DISC1, a gene disrupted by a translocation segregating with schizophrenia". Genomics 67 (1): 69–77. doi:10.1006/geno.2000.6239. PMID 10945471.
• Meng G, Aoki K, Tokura K, Nakahara K, Inazawa J, Kasai M (2000). "Genomic structure and chromosomal localization of the gene encoding TRAX, a Translin-associated factor X". Journal of Human Genetics 45 (5): 305–8. doi:10.1007/s100380070022. PMID 11043515.
• Chennathukuzhi VM, Kurihara Y, Bray JD, Hecht NB (Apr 2001). "Trax (translin-associated factor X), a primarily cytoplasmic protein, inhibits the binding of TB-RBP (translin) to RNA". The Journal of Biological Chemistry 276 (16): 13256–63. doi:10.1074/jbc.M009707200. PMID 11278549.
• Erdemir T, Bilican B, Oncel D, Goding CR, Yavuzer U (Jan 2002). "DNA damage-dependent interaction of the nuclear matrix protein C1D with Translin-associated factor X (TRAX)". Journal of Cell Science 115 (Pt 1): 207–16. PMID 11801738.
• Bray JD, Chennathukuzhi VM, Hecht NB (Jun 2002). "Identification and characterization of cDNAs encoding four novel proteins that interact with translin associated factor-X". Genomics 79 (6): 799–808. doi:10.1006/geno.2002.6779. PMID 12036294.
• Wu RF, Osatomi K, Terada LS, Uyeda K (Dec 2003). "Identification of Translin/Trax complex as a glucose response element binding protein in liver". Biochimica et Biophysica Acta 1624 (1-3): 29–35. doi:10.1016/j.bbagen.2003.09.002. PMID 14642810.
• Yang S, Cho YS, Chennathukuzhi VM, Underkoffler LA, Loomes K, Hecht NB (Mar 2004). "Translin-associated factor X is post-transcriptionally regulated by its partner protein TB-RBP, and both are essential for normal cell proliferation". The Journal of Biological Chemistry 279 (13): 12605–14. doi:10.1074/jbc.M313133200. PMID 14711818.
• Gocke CB, Yu H, Kang J (Feb 2005). "Systematic identification and analysis of mammalian small ubiquitin-like modifier substrates". The Journal of Biological Chemistry 280 (6): 5004–12. doi:10.1074/jbc.M411718200. PMID 15561718.
• Thomson PA, Wray NR, Millar JK, Evans KL, Hellard SL, Condie A, Muir WJ, Blackwood DH, Porteous DJ (Jul 2005). "Association between the TRAX/DISC locus and both bipolar disorder and schizophrenia in the Scottish population". Molecular Psychiatry 10 (7): 657–68, 616. doi:10.1038/sj.mp.4001669. PMID 15838535.
• Gupta GD, Makde RD, Kamdar RP, D'Souza JS, Kulkarni MG, Kumar V, Rao BJ (Jun 2005). "Co-expressed recombinant human Translin-Trax complex binds DNA". FEBS Letters 579 (14): 3141–6. doi:10.1016/j.febslet.2005.05.007. PMID 15919079.
• Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (Oct 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.