Zinc D-Ala-D-Ala carboxypeptidase

Zinc D-Ala-D-Ala carboxypeptidase
Identifiers
EC number	3.4.17.14
CAS number	213189-85-6
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Search PMC articles PubMed articles NCBI proteins

Zinc D-Ala-D-Ala carboxypeptidase (EC 3.4.17.14, Zn²⁺ G peptidase, D-alanyl-D-alanine hydrolase, D-alanyl-D-alanine-cleaving carboxypeptidase, DD-carboxypeptidase, G enzyme, DD-carboxypeptidase-transpeptidase) is an enzyme.^[1][2][3] This enzyme catalyses the following chemical reaction

Cleavage of the bond: (Ac)2-L-lysyl-D-alanyl--D-alanine

This is a zinc enzyme. Catalyses carboxypeptidation but not transpeptidation reactions involved in bacterial cell wall metabolism.

References

1. Dideberg, O., Charlier, P., Dive, G., Joris, B., Frère, J.M. and Ghuysen, J.M. (1982). "Structure of a Zn²⁺-containing D-alanyl-D-alanine-cleaving carboxypeptidase at 2.5 Å resolution". Nature 299 (5882): 469–470. doi:10.1038/299469a0. PMID 7121588.
2. Joris, B., Van Beeumen, J., Casagrande, F., Gerday, C., Frère, J.-M. and Ghuysen, J.-M. (1983). "The complete amino acid sequence of the Zn²⁺-containing D-alanyl-D-alanine-cleaving carboxypeptidase of Streptomyces albus G". Eur. J. Biochem. 130 (1): 53–69. doi:10.1111/j.1432-1033.1983.tb07116.x. PMID 6825689.
3. Ghuysen, J.-M., Frère, J.-M., Leyh-Bouille, M., Nguyen-Distèche, M., Coyette, J., Dusart, J., Joris, B., Duez, C., Dideberg, O., Charlier, P., Dive, G. and Lamotte-Brasseur, J. (1984). "Bacterial wall peptidoglycan, DD-peptidases and β-lactam antibiotics". Scand. J. Infect. Dis. Suppl. 42: 17–37. PMID 6597561.

External links

• Zinc D-Ala-D-Ala carboxypeptidase at the US National Library of Medicine Medical Subject Headings (MeSH)