(+)-epicubenol synthase

(+)-epicubenol synthase
Identifiers
EC number	4.2.3.64
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Search PMC articles PubMed articles NCBI proteins

(+)-epicubenol synthase (EC 4.2.3.64, farnesyl pyrophosphate cyclase) is an enzyme with systematic name (2E,6E)-farnesyl-diphosphate diphosphate-lyase ((+)-epicubenol-forming).^{[1][2][3][4][5]} This enzyme catalyses the following chemical reaction

(2E,6E)-farnesyl diphosphate + H₂O $\rightleftharpoons$ (+)-epicubenol + diphosphate

This enzyme requires Mg²⁺.

References

1. Cane, D.E., Tandon, M., and Prabhakaran, P.C. (1993). "Epicubenol synthase and the enzymatic cyclization of farnesyl diphosphate". J. Am. Chem. Soc. 115: 8103–8106. doi:10.1021/ja00071a023.
2. Cane, D.E. and Tandon, M. (1994). "Biosynthesis of (+)-epicubenol.". Tetrahedron Lett. 35: 5355–5358. doi:10.1016/s0040-4039(00)73498-8.
3. Cane, D.E. and Tandon, M. (1995). "Epicubenol synthase and the stereochemistry of the enzymatic cyclization of farnesyl and nerolidyl diphosphate". J. Am. Chem. Soc. 117: 5602–5603. doi:10.1021/ja00125a029.
4. Nabeta, K., Kigure, K., Fujita, M., Nagoya, T., Ishikawa, T., Okuyama, H. and Takasawa, T. (1995). "Bioynthesis of (+)-cubenene and (+)-epicubenol by cell-free extracts of cultured cells of Heteroscyphus planus and cyclization of [²H]farnesyl diphosphates". J. Chem. Soc., Perkin Trans. 1: 1935–1939. doi:10.1039/p19950001935.
5. Nabeta, K., Fujita, M., Komuro, K., Katayama, K., and Takasawa, T. (1997). "In vitro biosynthesis of cadinanes by cell-free extracts of cultured cells of Heteroscyphus planus". J. Chem. Soc., Perkin Trans. 1: 2065–2070. doi:10.1039/a701145h.

External links

• ( )-epicubenol synthase at the US National Library of Medicine Medical Subject Headings (MeSH)