(-)-endo-fenchol synthase

(−)-endo-fenchol synthase
Identifiers
EC number	4.2.3.10
CAS number	117758-41-5
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Gene Ontology	AmiGO / EGO
Search PMC articles PubMed articles NCBI proteins

In enzymology, a (−)-endo-fenchol synthase (EC 4.2.3.10) is an enzyme that catalyzes the chemical reaction

geranyl diphosphate + H₂O $\rightleftharpoons$ (−)-endo-fenchol + diphosphate

Thus, the two substrates of this enzyme are geranyl diphosphate and H₂O, whereas its two products are (−)-endo-fenchol and diphosphate.

This enzyme belongs to the family of lyases, specifically those carbon-oxygen lyases acting on phosphates. The systematic name of this enzyme class is geranyl-diphosphate diphosphate-lyase [cyclizing, (−)-endo-fenchol-forming]. Other names in common use include (−)-endo-fenchol cyclase, and geranyl pyrophosphate:(−)-endo-fenchol cyclase. This enzyme participates in monoterpenoid biosynthesis.

References

• Croteau R, Miyazaki JH, Wheeler CJ (1989). "Monoterpene biosynthesis: mechanistic evaluation of the geranyl pyrophosphate:(−)-endo-fenchol cyclase from fennel (Foeniculum vulgare)". Arch. Biochem. Biophys. 269 (2): 507–16. doi:10.1016/0003-9861(89)90134-3. PMID 2919880.
• Croteau R, Satterwhite DM, Wheeler CJ, Felton NM (1988). "Biosynthesis of monoterpenes. Stereochemistry of the enzymatic cyclization of geranyl pyrophosphate to (−)-endo-fenchol". J. Biol. Chem. 263 (30): 15449–53. PMID 3170591.