2-methylisoborneol synthase

2-methylisoborneol synthase
Identifiers
EC number	4.2.3.118
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Search PMC articles PubMed articles NCBI proteins

2-methylisoborneol synthase (EC 4.2.3.118, sco7700, 2-MIB cyclase, MIB synthase, MIBS) is an enzyme with systematic name (E)-2-methylgeranyl-diphosphate diphosphate-lyase (cyclizing, 2-methylisoborneol-forming).^[1][2][3] This enzyme catalyses the following chemical reaction

(E)-2-methylgeranyl diphosphate + H₂O $\rightleftharpoons$ 2-methylisoborneol + diphosphate

The product, 2-methylisoborneol, is a characteristic odiferous compound with a musty smell produced by soil microorganisms.

References

1. Wang, C.M. and Cane, D.E. (2008). "Biochemistry and molecular genetics of the biosynthesis of the earthy odorant methylisoborneol in Streptomyces coelicolor". J. Am. Chem. Soc. 130: 8908–8909. doi:10.1021/ja803639g. PMID 18563898.
2. Komatsu, M., Tsuda, M., Omura, S., Oikawa, H. and Ikeda, H. (2008). "Identification and functional analysis of genes controlling biosynthesis of 2-methylisoborneol". Proc. Natl. Acad. Sci. USA 105: 7422–7427. doi:10.1073/pnas.0802312105. PMID 18492804.
3. Giglio, S., Chou, W.K., Ikeda, H., Cane, D.E. and Monis, P.T. (2011). "Biosynthesis of 2-methylisoborneol in cyanobacteria". Environ. Sci. Technol. 45: 992–998. doi:10.1021/es102992p. PMID 21174459.

External links

• 2-methylisoborneol synthase at the US National Library of Medicine Medical Subject Headings (MeSH)