| 2005–06 game log | 
| 
November: 1–15 (Home: 1–8; Road: 0–7) 
 
| Game | Date Time
 | Team | Score | High points | High rebounds | High assists | Location Attendance
 | Record |  
| 1 | November 2 | Washington | L 96–99 | Jalen Rose (20) | Chris Bosh (14) | Mike James (7) | Air Canada Centre 18,106
 | 0–1 |  
| 2 | November 4 | New Jersey | L 92–102 | José Calderón, Morris Peterson (20) | Morris Peterson (8) | José Calderón (7) | Air Canada Centre 18,586
 | 0–2 |  
| 3 | November 5 | @ Detroit | L 84–117 | Jalen Rose (25) | Chris Bosh, Jalen Rose (7) | José Calderón (10) | The Palace of Auburn Hills 22,076
 | 0–3 |  
| 4 | November 7 | Cleveland | L 93–105 | Chris Bosh (26) | Chris Bosh (12) | José Calderón (7) | Air Canada Centre 18,281
 | 0–4 |  
| 5 | November 11 | Utah | L 84–99 | Chris Bosh (19) | Chris Bosh (10) | José Calderón, Mike James (4) | Air Canada Centre 15,617
 | 0–5 |  
| 6 | November 13 | Seattle | L 121–126 (OT) | Mike James (36) | Charlie Villanueva (12) | José Calderón (12) | Air Canada Centre 15,033
 | 0–6 |  
| 7 | November 15 | @ Philadelphia | L 92–104 | Charlie Villanueva (27) | Chris Bosh (17) | Jalen Rose (5) | Wachovia Center 12,211
 | 0–7 |  
| 8 | November 16 | Philadelphia | L 115–121 | Mike James (38) | Chris Bosh (10) | Mike James (9) | Air Canada Centre 16,490
 | 0–8 |  
| 9 | November 18 | @ Boston | L 93–100 | Chris Bosh (24) | Chris Bosh (14) | Mike James (7) | TD Banknorth Garden 17,002
 | 0–9 |  
| 10 | November 20 | Miami | W 107–94 | Chris Bosh (27) | Chris Bosh, Charlie Villanueva (12) | José Calderón (9) | Air Canada Centre 17,594
 | 1–9 |  
| 11 | November 22 | @ Phoenix | L 82–90 | Chris Bosh (23) | Chris Bosh, Charlie Villanueva (8) | Mike James (6) | America West Arena 16,259
 | 1–10 |  
| 12 | November 23 | @ L.A. Clippers | L 100–103 | Chris Bosh (24) | Chris Bosh (9) | Mike James (8) | Staples Center 15,927
 | 1–11 |  
| 13 | November 25 | @ Sacramento | L 104–106 | Chris Bosh (22) | Morris Peterson (9) | José Calderón, Jalen Rose (6) | ARCO Arena 17,317
 | 1–12 |  
| 14 | November 26 | @ Golden State | L 91–117 | Chris Bosh, Morris Peterson (21) | Morris Peterson (8) | José Calderón (6) | The Arena in Oakland 17,119
 | 1–13 |  
| 15 | November 28 | Dallas | L 91–93 | Chris Bosh (26) | Chris Bosh (10) | José Calderón (8) | Air Canada Centre 15,789
 | 1–14 |  
| 16 | November 30 | Memphis | L 66–92 | Chris Bosh (15) | Chris Bosh (8) | José Calderón (7) | Air Canada Centre 14,993
 | 1–15 |  | 
| 
December: 7–7 (Home: 1–4; Road: 6–3) 
 
| Game | Date Time
 | Team | Score | High points | High rebounds | High assists | Location Attendance
 | Record |  
| 17 | December 2 | @ Atlanta | W 102–101 | Chris Bosh (23) | Charlie Villanueva (10) | Mike James (7) | Philips Arena 12,261
 | 2–15 |  
| 18 | December 3 | @ New Jersey | W 95–82 | Chris Bosh (29) | Chris Bosh (13) | José Calderón (8) | Continental Airlines Arena 14,613
 | 3–15 |  
| 19 | December 6 | @ Washington | L 111–119 (OT) | Chris Bosh (27) | Chris Bosh, José Calderón (9) | José Calderón (13) | MCI Center 12,401
 | 3–16 |  
| 20 | December 7 | L.A. Lakers | L 91–102 | Chris Bosh (22) | Chris Bosh (10) | Chris Bosh (6) | Air Canada Centre 18,821
 | 3–17 |  
| 21 | December 10 | @ Charlotte | W 111–103 | Chris Bosh (30) | Chris Bosh (11) | Mike James (6) | Charlotte Bobcats Arena 15,163
 | 4–17 |  
| 22 | December 14 | Chicago | L 94–105 | Chris Bosh (25) | Morris Peterson (7) | José Calderón, Mike James (6) | Air Canada Centre 16,169
 | 4–18 |  
| 23 | December 16 | Golden State | L 98–108 | Chris Bosh (27) | Charlie Villanueva (9) | José Calderón (11) | Air Canada Centre 15,829
 | 4–19 |  
| 24 | December 18 | Philadelphia | L 80–107 | Chris Bosh (22) | Rafael Araújo, Chris Bosh, Morris Peterson, Charlie Villanueva (7) | Morris Peterson (4) | Air Canada Centre 18,918
 | 4–20 |  
| 25 | December 19 | @ Orlando | W 92–90 | Chris Bosh, Morris Peterson (19) | Chris Bosh (12) | Darrick Martin (7) | TD Waterhouse Centre 12,511
 | 5–20 |  
| 26 | December 21 | @ Houston | W 94–81 | Mike James (19) | Chris Bosh (8) | José Calderón, Morris Peterson (7) | Toyota Center 14,901
 | 6–20 |  
| 27 | December 23 | @ San Antonio | L 90–95 | Jalen Rose (19) | Morris Peterson (11) | José Calderón (5) | SBC Center 18,797
 | 6–21 |  
| 28 | December 27 | @ Detroit | L 106–113 | Chris Bosh (37) | Chris Bosh (11) | Chris Bosh (5) | The Palace of Auburn Hills 22,076
 | 6–22 |  
| 29 | December 28 | Atlanta | W 108–102 | Mike James (28) | Chris Bosh, Mike James (6) | Mike James (9) | Air Canada Centre 18,326
 | 7–22 |  
| 30 | December 30 | @ Indiana | W 99–97 | Charlie Villanueva (25) | Chris Bosh (12) | Mike James (10) | Conseco Fieldhouse 18,345
 | 8–22 |  | 
| 
January: 7–8 (Home: 5–2; Road: 2–6) 
 
| Game | Date Time
 | Team | Score | High points | High rebounds | High assists | Location Attendance
 | Record |  
| 31 | January 3 | @ Atlanta | W 108–97 | Mike James (28) | Chris Bosh (10) | Mike James (6) | Philips Arena 10,048
 | 9–22 |  
| 32 | January 4 | Orlando | W 121–97 | Charlie Villanueva (24) | Rafael Araújo (9) | Mike James (7) | Air Canada Centre 14,085
 | 10–22 |  
| 33 | January 6 | Houston | W 112–92 | Mike James (30) | Chris Bosh (16) | Mike James (8) | Air Canada Centre 17,460
 | 11–22 |  
| 34 | January 8 | New Jersey | L 104–105 | Chris Bosh (27) | Matt Bonner (8) | Mike James (7) | Air Canada Centre 18,935
 | 11–23 |  
| 35 | January 9 | @ Chicago | L 104–113 | Chris Bosh (26) | Matt Bonner (9) | Mike James (13) | United Center 21,103
 | 11–24 |  
| 36 | January 11 | Charlotte | W 95–86 | Chris Bosh (29) | Morris Peterson (11) | Mike James (7) | Air Canada Centre 14,098
 | 12–24 |  
| 37 | January 15 | New York | W 129–103 | Jalen Rose (31) | Chris Bosh, Charlie Villanueva (6) | José Calderón (10) | Air Canada Centre 17,393
 | 13–24 |  
| 38 | January 17 | @ Utah | L 98–111 | Chris Bosh (27) | Matt Bonner, Chris Bosh (6) | José Calderón, Mike James (3) | Delta Center 17,831
 | 13–25 |  
| 39 | January 18 | @ Portland | L 94–96 | Jalen Rose (23) | Chris Bosh (9) | Mike James (7) | Rose Garden 12,315
 | 13–26 |  
| 40 | January 20 | @ Seattle | W 121–113 | Chris Bosh (29) | Chris Bosh (13) | Jalen Rose (7) | KeyArena 15,261
 | 14–26 |  
| 41 | January 22 | @ L.A. Lakers | L 104–122 | Mike James (26) | Chris Bosh (8) | Mike James (10) | Staples Center 18,997
 | 14–27 |  
| 42 | January 23 | @ Denver | L 101–107 | Mike James (22) | Matt Bonner (9) | Chris Bosh, Mike James (4) | Pepsi Center 14,826
 | 14–28 |  
| 43 | January 25 | Chicago | L 88–104 | Chris Bosh (20) | Chris Bosh (7) | Mike James (7) | Air Canada Centre 14,198
 | 14–29 |  
| 44 | January 27 | @ Milwaukee | L 87–108 | Chris Bosh (21) | Charlie Villanueva (6) | José Calderón (7) | Bradley Center 14,867
 | 14–30 |  
| 45 | January 29 | Sacramento | W 124–123 (OT) | Morris Peterson (23) | Morris Peterson (10) | José Calderón (5) | Air Canada Centre 16,573
 | 15–30 |  | 
| 
February: 5–6 (Home: 3–2; Road: 2–4) 
 
| Game | Date Time
 | Team | Score | High points | High rebounds | High assists | Location Attendance
 | Record |  
| 46 | February 1 | Washington | W 117–112 | Chris Bosh (33) | Chris Bosh (13) | Chris Bosh, José Calderón, Mike James, Jalen Rose (4) | Air Canada Centre 13,640
 | 16–30 |  
| 47 | February 3 | New York | W 104–90 | Chris Bosh (29) | Charlie Villanueva (9) | Mike James (10) | Air Canada Centre 15,858
 | 17–30 |  
| 48 | February 5 | L.A. Clippers | L 113–115 (OT) | Chris Bosh (29) | Chris Bosh (16) | Mike James (7) | Air Canada Centre 15,541
 | 17–31 |  
| 49 | February 8 | San Antonio | L 118–125 (OT) | Mike James (36) | Chris Bosh (14) | Mike James (7) | Air Canada Centre 19,284
 | 17–32 |  
| 50 | February 10 | @ Charlotte | W 88–73 | Charlie Villanueva (24) | Chris Bosh, Morris Peterson (10) | Mike James (8) | Charlotte Bobcats Arena 17,472
 | 18–32 |  
| 51 | February 12 | Portland | W 114–81 | Morris Peterson (22) | Chris Bosh, Charlie Villanueva (9) | Mike James (6) | Air Canada Centre 15,014
 | 19–32 |  
| 52 | February 13 | @ Minnesota | W 98–94 | Mike James (27) | José Calderón, Antonio Davis (5) | Mike James (6) | Target Center 14,911
 | 20–32 |  
| 53 | February 15 | @ New York | L 96–98 | Chris Bosh (25) | Chris Bosh, Morris Peterson (7) | Mike James (9) | Madison Square Garden 18,901
 | 20–33 |  
| 54 | February 21 | @ Memphis | L 88–94 | Chris Bosh (26) | Charlie Villanueva (10) | José Calderón (7) | FedExForum 15,385
 | 20–34 |  
| 55 | February 25 | @ Dallas | L 113–115 (OT) | Chris Bosh (29) | Chris Bosh (13) | Mike James (7) | American Airlines Center 19,791
 | 20–35 |  
| 56 | February 27 | @ Miami | L 94–101 | Mike James (26) | Charlie Villanueva (11) | Chris Bosh, José Calderón, Antonio Davis, Mike James, Morris Peterson (3) | American Airlines Arena 19,600
 | 20–36 |  | 
| 
March: 6–10 (Home: 4–6; Road: 2–4) 
 
| Game | Date Time
 | Team | Score | High points | High rebounds | High assists | Location Attendance
 | Record |  
| 57 | March 1 | Atlanta | L 111–113 (OT) | Chris Bosh (27) | Charlie Villanueva (11) | Chris Bosh (5) | Air Canada Centre 15,137
 | 20–37 |  
| 58 | March 4 | @ New Jersey | L 100–105 (OT) | Morris Peterson (25) | Chris Bosh, Charlie Villanueva (11) | Mike James (7) | Continental Airlines Arena 16,215
 | 20–38 |  
| 59 | March 5 | Boston | W 111–105 | Morris Peterson (27) | Chris Bosh (10) | Mike James (6) | Air Canada Centre 16,623
 | 21–38 |  
| 60 | March 7 | @ Cleveland | L 99–106 | Mike James (31) | Charlie Villanueva (11) | Mike James (8) | Quicken Loans Arena 18,077
 | 21–39 |  
| 61 | March 8 | Cleveland | L 97–98 | Morris Peterson (31) | Chris Bosh (14) | Mike James (7) | Air Canada Centre 19,800
 | 21–40 |  
| 62 | March 10 | Denver | L 97–108 | Mike James (26) | Chris Bosh (15) | José Calderón (5) | Air Canada Centre 17,806
 | 21–41 |  
| 63 | March 12 | Indiana | W 93–89 | Morris Peterson (25) | Chris Bosh (8) | Mike James (4) | Air Canada Centre 17,573
 | 22–41 |  
| 64 | March 14 | @ Philadelphia | W 111–97 | Chris Bosh (31) | Charlie Villanueva (10) | Darrick Martin (12) | Wachovia Center 14,917
 | 23–41 |  
| 65 | March 15 | Detroit | L 98–105 | Mike James (24) | Chris Bosh (11) | Mike James (11) | Air Canada Centre 19,800
 | 23–42 |  
| 66 | March 17 | Milwaukee | W 97–96 | Chris Bosh (27) | Chris Bosh (10) | Mike James (6) | Air Canada Centre 17,273
 | 24–42 |  
| 67 | March 21 | @ New York | W 114–109 | Mike James (37) | Mike James, Charlie Villanueva (8) | Mike James (5) | Madison Square Garden 18,131
 | 25–42 |  
| 68 | March 22 | @ Boston | L 96–110 | Mike James (31) | Chris Bosh (11) | Chris Bosh (8) | TD Banknorth Garden 18,624
 | 25–43 |  
| 69 | March 24 | Minnesota | W 97–77 | Morris Peterson (21) | Chris Bosh (15) | Mike James (5) | Air Canada Centre 17,493
 | 26–43 |  
| 70 | March 26 | @ Milwaukee | L 116–125 (OT) | Charlie Villanueva (48) | Charlie Villanueva (9) | Mike James (10) | Bradley Center 16,317
 | 26–44 |  
| 71 | March 29 | Miami | L 94–98 | Morris Peterson (28) | Charlie Villanueva (13) | Mike James (12) | Air Canada Centre 19,973
 | 26–45 |  
| 72 | March 31 | Phoenix | L 126–140 | Morris Peterson (38) | Pape Sow (15) | Mike James (10) | Air Canada Centre 19,800
 | 26–46 |  | 
| 
April: 1–9 (Home: 1–4; Road: 0–5) 
 
| Game | Date Time
 | Team | Score | High points | High rebounds | High assists | Location Attendance
 | Record |  
| 73 | April 2 | New Orleans/Oklahoma City | L 113–120 (2OT) | Morris Peterson (27) | Charlie Villanueva (18) | Mike James (10) | Air Canada Centre 15,079
 | 26–47 |  
| 74 | April 4 | Boston | L 120–124 | Morris Peterson (32) | Matt Bonner (13) | Andre Barrett, Morris Peterson (6) | Air Canada Centre 16,598
 | 26–48 |  
| 75 | April 5 | @ Indiana | L 103–111 | Mike James (34) | Mike James, Charlie Villanueva (11) | Mike James (8) | Conseco Fieldhouse 14,037
 | 26–49 |  
| 76 | April 7 | @ New Orleans/Oklahoma City | L 89–95 | Mike James (36) | Loren Woods (10) | Mike James (4) | Ford Center 18,854
 | 26–50 |  
| 77 | April 9 | Charlotte | L 88–94 | Mike James (32) | Joey Graham (9) | Mike James (10) | Air Canada Centre 17,679
 | 26–51 |  
| 78 | April 11 | @ Miami | L 97–106 | Mike James (32) | Darrick Martin, Charlie Villanueva (5) | Mike James (6) | American Airlines Arena 19,600
 | 26–52 |  
| 79 | April 12 | @ Orlando | L 96–103 | Morris Peterson (23) | Morris Peterson (8) | Mike James, Morris Peterson (5) | TD Waterhouse Centre 15,009
 | 26–53 |  
| 80 | April 14 | Detroit | W 108–103 | Mike James (39) | Loren Woods (11) | José Calderón (9) | Air Canada Centre 19,800
 | 27–53 |  
| 81 | April 17 | Indiana | L 95–120 | Morris Peterson (27) | Loren Woods (14) | José Calderón (8) | Air Canada Centre 18,267
 | 27–54 |  
| 82 | April 19 | @ Chicago | L 106–127 | Morris Peterson, Charlie Villanueva (29) | Charlie Villanueva (10) | José Calderón (5) | United Center 20,364
 | 27–55 |  | 
| 2005–06 season schedule |