3-hydroxydecanoyl-(acyl-carrier-protein) dehydratase

3-hydroxydecanoyl-(acyl-carrier-protein) dehydratase
Identifiers
EC number	4.2.1.60
CAS number	9030-79-9
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Search PMC articles PubMed articles NCBI proteins

3-hydroxydecanoyl-(acyl-carrier-protein) dehydratase (EC 4.2.1.60, D-3-hydroxydecanoyl-[acyl-carrier protein] dehydratase, 3-hydroxydecanoyl-acyl carrier protein dehydrase, 3-hydroxydecanoyl-acyl carrier protein dehydratase, beta-hydroxydecanoyl thioester dehydrase, beta-hydroxydecanoate dehydrase, beta-hydroxydecanoyl thiol ester dehydrase, FabA, beta-hydroxyacyl-acyl carrier protein dehydratase, HDDase, beta-hydroxyacyl-ACP dehydrase, (3R)-3-hydroxydecanoyl-[acyl-carrier-protein] hydro-lyase) is an enzyme with systematic name (3R)-3-hydroxydecanoyl-(acyl-carrier protein) hydro-lyase.^{[1][2][3][4][5][6][7]} This enzyme catalyses the following chemical reaction

(1) a (3R)-3-hydroxydecanoyl-[acyl-carrier protein] $\rightleftharpoons$ a trans-dec-2-enoyl-[acyl-carrier protein] + H₂O

(2) a (3R)-3-hydroxydecanoyl-[acyl-carrier protein] $\rightleftharpoons$ a cis-dec-3-enoyl-[acyl-carrier protein] + H₂O

This enzyme is specific for C10 chain length.

References

1. Kass, L.R., Brock, D.J.H. and Bloch, K. (1967). "β-Hydroxydecanoyl thioester dehydrase. I. Purification and properties". J. Biol. Chem. 242 (19): 4418–4431. PMID 4863739.
2. Brock, D.J.H., Kass, L.R. and Bloch, K. (1967). "β-Hydroxydecanoyl thioester dehydrase. II. Mode of action". J. Biol. Chem. 242 (19): 4432–4440. PMID 4863740.
3. Sharma, A., Henderson, B.S., Schwab, J.M. and Smith, J.L. (1990). "Crystallization and preliminary X-ray analysis of β-hydroxydecanoyl thiol ester dehydrase from Escherichia coli". J. Biol. Chem. 265 (9): 5110–5112. PMID 2180957.
4. Magnuson, K., Jackowski, S., Rock, C.O. and Cronan, J.E., Jr. (1993). "Regulation of fatty acid biosynthesis in Escherichia coli". Microbiol. Rev. 57 (3): 522–542. PMID 8246839.
5. Bloch, K. (1969). "Enzymatic synthesis of monounsaturated fatty acids". Acc. Chem. Res. 2: 193–202. doi:10.1021/ar50019a001.
6. Wang, H. and Cronan, J.E. (2004). "Functional replacement of the FabA and FabB proteins of Escherichia coli fatty acid synthesis by Enterococcus faecalis FabZ and FabF homologues". J. Biol. Chem. 279: 34489–34495. doi:10.1074/jbc.M403874200. PMID 15194690.
7. Cronan, J.E., Jr. and Rock, C.O. (1996). "Biosynthesis of membrane lipids". In Neidhardt, F.C. Escherichia coli and Salmonella: Cellular and Molecular Biology 1 (2nd ed.). Washington, DC: ASM Press. pp. 612–636.

External links

• 3-hydroxydecanoyl-(acyl-carrier-protein) dehydratase at the US National Library of Medicine Medical Subject Headings (MeSH)