3-hydroxypropionyl-CoA dehydratase

3-hydroxypropionyl-CoA dehydratase (EC 4.2.1.116) is an enzyme with systematic name 3-hydroxypropionyl-CoA hydro-lyase.^[1]^[2] This enzyme catalyses the following chemical reaction

3-hydroxypropanoyl-CoA

\rightleftharpoons

acrylyl-CoA + H₂O

This enzyme catalyses a step in the 3-hydroxypropionate/4-hydroxybutyrate cycle.

References

↑ Berg, I.A., Kockelkorn, D., Buckel, W. and Fuchs, G. (2007). "A 3-hydroxypropionate/4-hydroxybutyrate autotrophic carbon dioxide assimilation pathway in Archaea". Science 318: 1782–1786. doi:10.1126/science.1149976. PMID 18079405.
↑ Teufel, R., Kung, J.W., Kockelkorn, D., Alber, B.E. and Fuchs, G. (2009). "3-hydroxypropionyl-coenzyme A dehydratase and acryloyl-coenzyme A reductase, enzymes of the autotrophic 3-hydroxypropionate/4-hydroxybutyrate cycle in the Sulfolobales". J. Bacteriol. 191: 4572–4581. doi:10.1128/JB.00068-09. PMC 2704735. PMID 19429610.

External links

3-hydroxypropionyl-CoA dehydratase at the US National Library of Medicine Medical Subject Headings (MeSH)

Carbon-oxygen lyases (EC 4.2) (primarily dehydratases)

4.2.1: Hydro-Lyases	Carbonic anhydrase Fumarase Aconitase Enolase Alpha Enolase 2 Enoyl-CoA hydratase/3-Hydroxyacyl ACP dehydrase Methylglutaconyl-CoA hydratase Tryptophan synthase Cystathionine beta synthase Porphobilinogen synthase 3-Isopropylmalate dehydratase Urocanase Uroporphyrinogen III synthase Nitrile hydratase

4.2.2: Acting on polysaccharides	Hyaluronate lyase

4.2.3: Acting on phosphates	Threonine synthase

4.2.99: Other	Carboxymethyloxysuccinate lyase

Enzymes

Activity	Active site Binding site Catalytic triad Oxyanion hole Enzyme promiscuity Catalytically perfect enzyme Coenzyme Cofactor Enzyme catalysis Enzyme kinetics Lineweaver–Burk plot Michaelis–Menten kinetics

Regulation	Allosteric regulation Cooperativity Enzyme inhibitor

Classification	EC number Enzyme superfamily Enzyme family List of enzymes

Types	EC1 Oxidoreductases(list) EC2 Transferases(list) EC3 Hydrolases(list) EC4 Lyases(list) EC5 Isomerases(list) EC6 Ligases(list)

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