4-Aminoquinoline

4-Aminoquinoline

Names
IUPAC name quinolin-4-amine
Identifiers
CAS Number	578-68-7
ChEMBL	ChEMBL58146
ChemSpider	61751
Jmol interactive 3D	Image
PubChem	68476
UNII	GTE5P5L97N
InChI InChI=1S/C9H8N2/c10-8-5-6-11-9-4-2-1-3-7(8)9/h1-6H,(H2,10,11) Key: FQYRLEXKXQRZDH-UHFFFAOYSA-N InChI=1S/C9H8N2/c10-8-5-6-11-9-4-2-1-3-7(8)9/h1-6H,(H2,10,11)
SMILES n1ccc(c2ccccc12)N
Properties
Chemical formula	C9H8N2
Molar mass	144.18 g·mol^−1
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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Infobox references

4-Aminoquinoline is a form of aminoquinoline with the amino group at the 4-position of the quinoline.

A variety of derivatives of 4-aminoquinoline are antimalarial agents useful in treating erythrocytic plasmodial infections. Examples include amodiaquine, chloroquine, and hydroxychloroquine.^[1]

• 

  Amodiaquine

• 

  Chloroquine

• 

  Hydroxychloroquine

References

1. Bray PG, Hawley SR, Ward SA (1996). "4-Aminoquinoline resistance of Plasmodium falciparum: insights from the study of amodiaquine uptake". Mol. Pharmacol. 50 (6): 1551–8. PMID 8967977.

External links

• Bourne SA, De Villiers K, Egan TJ (2006). "Three 4-aminoquinolines of antimalarial interest". Acta Crystallogr C 62 (Pt 2): o53–7. doi:10.1107/S0108270105041235. PMID 16456284.