Sulfadoxine
 | |
 | |
| Systematic (IUPAC) name | |
|---|---|
|
4-Amino-N-(5,6-dimethoxy-4-pyrimidinyl)benzenesulfonamide | |
| Clinical data | |
| AHFS/Drugs.com | International Drug Names |
| Identifiers | |
| CAS Number |
2447-57-6  |
| ATCvet code | QJ01EQ13 |
| PubChem | CID 17134 |
| DrugBank |
DB01299  |
| ChemSpider |
16218 |
| UNII |
88463U4SM5 |
| KEGG |
D00580 |
| ChEMBL |
CHEMBL1539 |
| NIAID ChemDB | 007816 |
| Chemical data | |
| Formula | C12H14N4O4S |
| Molar mass | 310.33 g/mol |
| |
| (what is this?) (verify) | |
Sulfadoxine (also spelled sulphadoxine) is an ultra-long-lasting sulfonamide previously used in combination with pyrimethamine to treat or prevent malaria.[1] Due to high levels of resistance, its use is no longer recommended routinely.[2] It is also used, usually in combination with other drugs, to treat or prevent various infections in livestock.[3]
It is on the World Health Organization's List of Essential Medicines, a list of the most important medication needed in a basic health system.[4]
Mechanism of action
Sulfadoxine competitively inhibits dihydropteroate synthase, interfering with folate synthesis.
Synthesis
See also
References
- ↑ Medical Treatment - Sulphadoxine and Pyrimethamine.
- ↑ Matondo SI, Temba GS, Kavishe AA, et al. (2014). "High levels of sulphadoxine-pyrimethamine resistance Pfdhfr-Pfdhps quintuple mutations: a cross sectional survey of six regions in Tanzania.". Malar J 13: 152. doi:10.1186/1475-2875-13-152. PMC 3998221. PMID 24751352.
- ↑ http://en.scientificcommons.org/19483411.
- ↑ "WHO Model List of EssentialMedicines" (PDF). World Health Organization. October 2013. Retrieved 22 April 2014.
- ↑ Bretschneider, H.; Richter, W.; Kl�Tzer, W. (1965). "Synthesen des 4-Sulfanilamido-5,6-dimethoxypyrimidins". Monatshefte f�r Chemie 96 (6): 1661. doi:10.1007/BF01185885. replacement character in
|last3=at position 3 (help); replacement character in|journal=at position 14 (help) - ↑ Gr�Ssner, A.; Montavon, M.; Schnider, O. (1965). "Disubstituierte 4-Sulfanilamido-pyrimidine". Monatshefte f�r Chemie 96 (6): 1677. doi:10.1007/BF01185886. replacement character in
|journal=at position 14 (help); replacement character in|last1=at position 3 (help)
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