4-hydroxybutanoyl-CoA dehydratase
4-hydroxybutanoyl-CoA dehydratase (EC 4.2.1.120) is an enzyme with systematic name 4-hydroxybutanoyl-CoA hydro-lyase.[1][2][3][4][5] This enzyme catalyses the following chemical reaction
- 4-hydroxybutanoyl-CoA but-3-enoyl-CoA + H2O
This enzyme contains FAD and a [4Fe-4S] iron-sulfur cluster.
References
- ↑ Bartsch, R.G. and Barker, H.A. (1961). "A vinylacetyl isomerase from Clostridium kluyveri". Arch. Biochem. Biophys. 92: 122–132. doi:10.1016/0003-9861(61)90226-0. PMID 13687513.
- ↑ Scherf, U., Sohling, B., Gottschalk, G., Linder, D. and Buckel, W. (1994). "Succinate-ethanol fermentation in Clostridium kluyveri: purification and characterisation of 4-hydroxybutyryl-CoA dehydratase/vinylacetyl-CoA Δ3-Δ2-isomerase". Arch. Microbiol. 161 (3): 239–245. doi:10.1007/bf00248699. PMID 8161284.
- ↑ Scherf, U. and Buckel, W. (1993). "Purification and properties of an iron-sulfur and FAD-containing 4-hydroxybutyryl-CoA dehydratase/vinylacetyl-CoA Δ3-Δ2-isomerase from Clostridium aminobutyricum". Eur. J. Biochem. 215 (2): 421–429. doi:10.1111/j.1432-1033.1993.tb18049.x. PMID 8344309.
- ↑ Muh, U., Cinkaya, I., Albracht, S.P. and Buckel, W. (1996). "4-Hydroxybutyryl-CoA dehydratase from Clostridium aminobutyricum: characterization of FAD and iron-sulfur clusters involved in an overall non-redox reaction". Biochemistry 35 (36): 11710–11718. doi:10.1021/bi9601363. PMID 8794752.
- ↑ Berg, I.A., Kockelkorn, D., Buckel, W. and Fuchs, G. (2007). "A 3-hydroxypropionate/4-hydroxybutyrate autotrophic carbon dioxide assimilation pathway in Archaea". Science 318: 1782–1786. doi:10.1126/science.1149976. PMID 18079405.
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