ACER2

Alkaline ceramidase 2
Identifiers
Symbols	ACER2 ; ALKCDase2; ASAH3L
External IDs	OMIM: 613492 MGI: 1920932 HomoloGene: 14986 IUPHAR: 2469 GeneCards: ACER2 Gene
EC number	3.5.1.23
Gene ontology Molecular function • ceramidase activity • dihydroceramidase activity Cellular component • Golgi membrane • Golgi apparatus • integral component of Golgi membrane Biological process • negative regulation of cell-matrix adhesion • sphingolipid metabolic process • ceramide metabolic process • activation of cysteine-type endopeptidase activity involved in apoptotic process • positive regulation of cell proliferation • positive regulation of cell death • sphingolipid biosynthetic process • response to retinoic acid • negative regulation of cell adhesion mediated by integrin • cellular response to drug • small molecule metabolic process • sphingosine biosynthetic process • negative regulation of protein glycosylation in Golgi Sources: Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	340485	230379
Ensembl	ENSG00000177076	ENSMUSG00000038007
UniProt	Q5QJU3	Q8VD53
RefSeq (mRNA)	NM_001010887	NM_001290541
RefSeq (protein)	NP_001010887	NP_001277470
Location (UCSC)	Chr 9: 19.41 – 19.45 Mb	Chr 4: 86.87 – 86.93 Mb
PubMed search

Alkaline ceramidase 2 also known as ACER2 is a ceramidase enzyme which in humans is encoded by the ACER2 gene.^[1]

Function

The ACER2/sphingosine pathway plays an important role in regulating integrin β1 subunit (ITGB1) maturation and cell adhesion mediated by β1 integrins.^[2]

References

1. Mao C, Obeid LM (September 2008). "Ceramidases: regulators of cellular responses mediated by ceramide, sphingosine, and sphingosine-1-phosphate". Biochim. Biophys. Acta 1781 (9): 424–34. doi:10.1016/j.bbalip.2008.06.002. PMC 2614331. PMID 18619555.
2. Sun W, Hu W, Xu R, Jin J, Szulc ZM, Zhang G, Galadari SH, Obeid LM, Mao C (February 2009). "Alkaline ceramidase 2 regulates beta1 integrin maturation and cell adhesion". FASEB J. 23 (2): 656–66. doi:10.1096/fj.08-115634. PMC 2630785. PMID 18945876.

Further reading

• Xu R, Jin J, Hu W; et al. (2006). "Golgi alkaline ceramidase regulates cell proliferation and survival by controlling levels of sphingosine and S1P.". FASEB J. 20 (11): 1813–25. doi:10.1096/fj.05-5689com. PMID 16940153.
• Strausberg RL, Feingold EA, Grouse LH; et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Humphray SJ, Oliver K, Hunt AR; et al. (2004). "DNA sequence and analysis of human chromosome 9.". Nature 429 (6990): 369–74. doi:10.1038/nature02465. PMC 2734081. PMID 15164053.
• Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Wan D, Gong Y, Qin W; et al. (2004). "Large-scale cDNA transfection screening for genes related to cancer development and progression.". Proc. Natl. Acad. Sci. U.S.A. 101 (44): 15724–9. doi:10.1073/pnas.0404089101. PMC 524842. PMID 15498874.