ASAH2B

N-acylsphingosine amidohydrolase (non-lysosomal ceramidase) 2B
Identifiers
Symbols	ASAH2B ; ASAH2C; ASAH2L; bA449O16.3; bA98I6.3
External IDs	OMIM: 610987 IUPHAR: 2493 GeneCards: ASAH2B Gene
EC number	3.5.1.23
Gene ontology Molecular function • ceramidase activity Cellular component • membrane fraction • mitochondrion Biological process • response to organic substance Sources: Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	653308	n/a
Ensembl	ENSG00000204147	n/a
UniProt	P0C7U1	n/a
RefSeq (mRNA)	NM_001079516	n/a
RefSeq (protein)	NP_001072984	n/a
Location (UCSC)	Chr 10: 50.74 – 50.82 Mb	n/a
PubMed search		n/a

Neutral ceramidase B also known as non-lysosomal ceramidase B or N-acylsphingosine amidohydrolase (non-lysosomal ceramidase) 2B or ASAH2B is a ceramidase enzyme which in humans is encoded by the ASAH2B gene.^[1][2]

Clinical significance

ASAH2B shows reduced expression with increasing age and further reduction in late onset Alzheimer's disease patients.^[1]

References

1. Avramopoulos D, Wang R, Valle D, Fallin MD, Bassett SS (April 2007). "A novel gene derived from a segmental duplication shows perturbed expression in Alzheimer's disease". Neurogenetics 8 (2): 111–20. doi:10.1007/s10048-007-0081-5. PMID 17334805.
2. Deloukas P, Earthrowl ME, Grafham DV; et al. (May 2004). "The DNA sequence and comparative analysis of human chromosome 10". Nature 429 (6990): 375–81. doi:10.1038/nature02462. PMID 15164054.

Further reading

• Brandenberger R, Wei H, Zhang S; et al. (2004). "Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation.". Nat. Biotechnol. 22 (6): 707–16. doi:10.1038/nbt971. PMID 15146197.