ASAH2C

N-acylsphingosine amidohydrolase (non-lysosomal ceramidase) 2C
Identifiers
Symbols	ASAH2C ; bA98I6.3
External IDs	HomoloGene: 121147 IUPHAR: 2494 GeneCards: ASAH2C Gene
EC number	3.5.1.23
Gene ontology Molecular function • ceramidase activity Biological process • sphingolipid metabolic process Sources: Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	653365	n/a
Ensembl	ENSG00000072444	n/a
UniProt	P0C7U2	n/a
RefSeq (mRNA)	XM_927086	n/a
RefSeq (protein)	XP_932179	n/a
Location (UCSC)	Chr 10: 47.52 – 47.53 Mb	n/a
PubMed search		n/a

Neutral ceramidase C also known as N-acylsphingosine amidohydrolase 2C or non-lysosomal ceramidase C or ASAH2C is a ceramidase enzyme which in humans is encoded by the ASAH2C gene.^[1]

References

1. Avramopoulos D, Wang R, Valle D, Fallin MD, Bassett SS (April 2007). "A novel gene derived from a segmental duplication shows perturbed expression in Alzheimer's disease". Neurogenetics 8 (2): 111–20. doi:10.1007/s10048-007-0081-5. PMID 17334805.

Further reading

• Choi MS, Anderson MA, Zhang Z; et al. (2003). "Neutral ceramidase gene: role in regulating ceramide-induced apoptosis.". Gene 315: 113–22. doi:10.1016/S0378-1119(03)00721-2. PMID 14557071.
• El Bawab S, Roddy P, Qian T; et al. (2000). "Molecular cloning and characterization of a human mitochondrial ceramidase.". J. Biol. Chem. 275 (28): 21508–13. doi:10.1074/jbc.M002522200. PMID 10781606.
• Tani M, Sano T, Ito M, Igarashi Y (2005). "Mechanisms of sphingosine and sphingosine 1-phosphate generation in human platelets.". J. Lipid Res. 46 (11): 2458–67. doi:10.1194/jlr.M500268-JLR200. PMID 16061940.
• Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Galadari S, Wu BX, Mao C; et al. (2006). "Identification of a novel amidase motif in neutral ceramidase.". Biochem. J. 393 (Pt 3): 687–95. doi:10.1042/BJ20050682. PMC 1360721. PMID 16229686.
• Deloukas P, Earthrowl ME, Grafham DV; et al. (2004). "The DNA sequence and comparative analysis of human chromosome 10.". Nature 429 (6990): 375–81. doi:10.1038/nature02462. PMID 15164054.
• Hwang YH, Tani M, Nakagawa T; et al. (2005). "Subcellular localization of human neutral ceramidase expressed in HEK293 cells.". Biochem. Biophys. Res. Commun. 331 (1): 37–42. doi:10.1016/j.bbrc.2005.03.134. PMID 15845354.
• Osawa Y, Uchinami H, Bielawski J; et al. (2005). "Roles for C16-ceramide and sphingosine 1-phosphate in regulating hepatocyte apoptosis in response to tumor necrosis factor-alpha.". J. Biol. Chem. 280 (30): 27879–87. doi:10.1074/jbc.M503002200. PMID 15946935.