ALDH1A3

Aldehyde dehydrogenase 1 family, member A3
Identifiers
Symbols	ALDH1A3 ; ALDH1A6; ALDH6; MCOP8; RALDH3
External IDs	OMIM: 600463 MGI: 1861722 HomoloGene: 68080 ChEMBL: 3579 GeneCards: ALDH1A3 Gene
EC number	1.2.1.5
Gene ontology Molecular function • retinal dehydrogenase activity • aldehyde dehydrogenase (NAD) activity • aldehyde dehydrogenase [NAD(P)+ activity] • protein homodimerization activity • thyroid hormone binding • NAD+ binding Cellular component • cytoplasm • cytosol • extracellular exosome Biological process • optic cup morphogenesis involved in camera-type eye development • retinoic acid biosynthetic process • locomotory behavior • nucleus accumbens development • inner ear morphogenesis • retinol metabolic process • retinoic acid metabolic process • retinal metabolic process • positive regulation of apoptotic process • embryonic eye morphogenesis • neuromuscular process controlling balance • oxidation-reduction process • righting reflex • olfactory pit development • face development Sources: Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	220	56847
Ensembl	ENSG00000184254	ENSMUSG00000015134
UniProt	P47895	Q9JHW9
RefSeq (mRNA)	NM_000693	NM_053080
RefSeq (protein)	NP_000684	NP_444310
Location (UCSC)	Chr 15: 100.88 – 100.92 Mb	Chr 7: 66.39 – 66.43 Mb
PubMed search

Aldehyde dehydrogenase 1 family, member A3, also known as ALDH1A3 or retinaldehyde dehydrogenase 3 (RALDH3), is an enzyme that in humans is encoded by the ALDH1A3 gene,^[1]

Function

Aldehyde dehydrogenase isozymes are thought to play a major role in the detoxification of aldehydes generated by alcohol metabolism and lipid peroxidation. The enzyme encoded by this gene uses retinal as a substrate, either in a free or a cellular retinol-binding protein form.^[2]

References

1. Hsu LC, Chang WC, Hiraoka L, Hsieh CL (November 1994). "Molecular cloning, genomic organization, and chromosomal localization of an additional human aldehyde dehydrogenase gene, ALDH6". Genomics 24 (2): 333–41. doi:10.1006/geno.1994.1624. PMID 7698756.
2. "Entrez Gene: ALDH1A3".

Further reading

• Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Wan C, Shi Y, Zhao X; et al. (2009). "Positive association between ALDH1A2 and schizophrenia in the Chinese population.". Prog. Neuropsychopharmacol. Biol. Psychiatry 33 (8): 1491–5. doi:10.1016/j.pnpbp.2009.08.008. PMID 19703508.
• Strausberg RL, Feingold EA, Grouse LH; et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Nishimura M, Yoshitsugu H, Naito S, Hiraoka I (2002). "Evaluation of gene induction of drug-metabolizing enzymes and transporters in primary culture of human hepatocytes using high-sensitivity real-time reverse transcription PCR.". Yakugaku Zasshi 122 (5): 339–61. doi:10.1248/yakushi.122.339. PMID 12040753.
• Cañestro C, Catchen JM, RodrÃguez-Marà A; et al. (2009). Gojobori, Takashi, ed. "Consequences of lineage-specific gene loss on functional evolution of surviving paralogs: ALDH1A and retinoic acid signaling in vertebrate genomes.". PLoS Genet. 5 (5): e1000496. doi:10.1371/journal.pgen.1000496. PMC 2682703. PMID 19478994.
• Saito A, Kawamoto M, Kamatani N (2009). "Association study between single-nucleotide polymorphisms in 199 drug-related genes and commonly measured quantitative traits of 752 healthy Japanese subjects.". J. Hum. Genet. 54 (6): 317–23. doi:10.1038/jhg.2009.31. PMID 19343046.
• Rexer BN, Zheng WL, Ong DE (2001). "Retinoic acid biosynthesis by normal human breast epithelium is via aldehyde dehydrogenase 6, absent in MCF-7 cells.". Cancer Res. 61 (19): 7065–70. PMID 11585737.
• Yoshida A, Rzhetsky A, Hsu LC, Chang C (1998). "Human aldehyde dehydrogenase gene family.". Eur. J. Biochem. 251 (3): 549–57. doi:10.1046/j.1432-1327.1998.2510549.x. PMID 9490025.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.