ALDH1L2
| Aldehyde dehydrogenase 1 family, member L2 | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||||||
| Symbols | ALDH1L2 ; mtFDH | ||||||||||||
| External IDs | OMIM: 613584 MGI: 2444680 HomoloGene: 51942 GeneCards: ALDH1L2 Gene | ||||||||||||
| EC number | 1.5.1.6 | ||||||||||||
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| Orthologs | |||||||||||||
| Species | Human | Mouse | |||||||||||
| Entrez | 160428 | 216188 | |||||||||||
| Ensembl | ENSG00000136010 | ENSMUSG00000020256 | |||||||||||
| UniProt | Q3SY69 | Q8K009 | |||||||||||
| RefSeq (mRNA) | NM_001034173 | NM_153543 | |||||||||||
| RefSeq (protein) | NP_001029345 | NP_705771 | |||||||||||
| Location (UCSC) |
Chr 12: 105.02 – 105.08 Mb |
Chr 10: 83.49 – 83.53 Mb | |||||||||||
| PubMed search | |||||||||||||
Aldehyde dehydrogenase 1 family, member L2 also known as ALDH1L2 is an enzyme that in humans is encoded by the ALDH1L2 gene.[1][2] ALDH1L2 is the mitochondrial isoform of a similar enzyme, ALDH1L1, which converts 10-formyltetrahydrofolate to tetrahydrofolate and carbon dioxide.[3][4]
References
- ↑ Strausberg RL, Feingold EA, Grouse LH; et al. (December 2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- ↑ Ota T, Suzuki Y, Nishikawa T; et al. (January 2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
- ↑ Krupenko NI, Dubard ME, Strickland KC, Moxley KM, Oleinik NV, Krupenko SA. "ALDH1L2 is the mitochondrial homolog of 10-formyltetrahydrofolate dehydrogenase." J Biol Chem. 2010 Jul 23;285(30):23056-63.
- ↑ Strickland KC, Krupenko NI, Dubard ME, Hu CJ, Tsybovsky Y, Krupenko SA. "Enzymatic properties of ALDH1L2, a mitochondrial 10-formyltetrahdyrofolate dehydrogenase." Chem Biol Interact. 2011 May 30;191(1-3):129-36.
Further reading
- Strickland KC, Hoeferlin LA, Oleinik NV; et al. (2010). "Acyl carrier protein-specific 4'-phosphopantetheinyl transferase activates 10-formyltetrahydrofolate dehydrogenase.". J. Biol. Chem. 285 (3): 1627–33. doi:10.1074/jbc.M109.080556. PMC 2804320. PMID 19933275.
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