ALDH8A1

Aldehyde dehydrogenase 8 family, member A1
Identifiers
Symbols	ALDH8A1 ; ALDH12; DJ352A20.2
External IDs	OMIM: 606467 HomoloGene: 23369 GeneCards: ALDH8A1 Gene
EC number	1.2.1.-
Gene ontology Molecular function • retinal dehydrogenase activity • aldehyde dehydrogenase (NAD) activity Cellular component • intracellular • cytosol • extracellular exosome Biological process • retinoic acid metabolic process • retinal metabolic process • 9-cis-retinoic acid biosynthetic process • oxidation-reduction process Sources: Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	64577	237320
Ensembl	ENSG00000118514	ENSMUSG00000037542
UniProt	Q9H2A2	Q8BH00
RefSeq (mRNA)	NM_001193480	NM_178713.4
RefSeq (protein)	NP_001180409	NP_848828.1
Location (UCSC)	Chr 6: 134.92 – 134.95 Mb	Chr 10: 21.37 – 21.4 Mb
PubMed search

Aldehyde dehydrogenase 8 family, member A1 also known as ALDH8A1 is an enzyme that in humans is encoded by the ALDH8A1 gene.^[1]

Function

This protein belongs to the aldehyde dehydrogenase family of proteins. It plays a role in a pathway of 9-cis-retinoic acid biosynthesis in vivo. This enzyme converts 9-cis-retinal into the retinoid X receptor ligand 9-cis-retinoic acid, and has approximately 40-fold higher activity with 9-cis-retinal than with all-trans-retinal. Therefore, it is the first known aldehyde dehydrogenase to show a preference for 9-cis-retinal relative to all-trans-retinal. Two transcript variants encoding distinct isoforms have been identified for this gene.^[2]

References

1. Lin M, Napoli JL (December 2000). "cDNA cloning and expression of a human aldehyde dehydrogenase (ALDH) active with 9-cis-retinal and identification of a rat ortholog, ALDH12". The Journal of Biological Chemistry 275 (51): 40106–12. doi:10.1074/jbc.M008027200. PMID 11007799.
2. "Entrez Gene: ALDH8A1".

This article incorporates text from the United States National Library of Medicine, which is in the public domain.