Adenain

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Adenain (EC 3.4.22.39) is an enzyme.^[1]^[2]^[3] This enzyme catalyses the following chemical reaction

Cleaves proteins of the adenovirus and its host cell at two consensus sites: -Yaa-Xaa-Gly-Gly-Xaa- and -Yaa-Xaa-Gly-Xaa-Gly- (in which Yaa is Met, Ile or Leu, and Xaa is any amino acid)

This cysteine endopeptidase is coded by adenoviruses.

References

↑ Webster, A., Hay, R.T. and Kemp, G. (1993). "The adenovirus protease is activated by a virus-coded disulphide-linked peptide". Cell 72: 97–104. doi:10.1016/0092-8674(93)90053-s. PMID 8422686.
↑ Ding, J.Z., McGrath, W.J., Sweet, R.M. and Mangel, W.F. (1996). "Crystal structure of the human adenovirus proteinase with its 11 residue cofactor". EMBO J. 15: 1778–1783. PMID 8617222.
↑ Weber, J.M. (1998). "Adenovirus protease". In Barrett, A.J., Rawlings, N.D. and Woessner, J.F. Handbook of Proteolytic Enzymes. London: Academic Press. pp. 741–743.

External links

Adenain at the US National Library of Medicine Medical Subject Headings (MeSH)

Proteases: cysteine proteases (EC 3.4.22)

Caspase	Caspase 1 Caspase 2 Caspase 3 Caspase 4 Caspase 5 Caspase 6 Caspase 7 Caspase 8 Caspase 9 Caspase 10 Caspase 12 Caspase 13 Caspase 14

Fruit-derived	Papain Ficain Bromelain Actinidain

Calpain	CAPN1 CAPN2 CAPN3 CAPN5 CAPN6 CAPN7 CAPN8 CAPN9 CAPN10 CAPN11 CAPN12 CAPN13 CAPN14 CAPNS1 CAPNS2

Cathepsin	B C F H K L1/L2 O S W Z

Other	Clostripain Cancer procoagulant Separase Autophagin Cruzipain

Proteins: enzymes

Activity	Active site Binding site Catalytic triad Oxyanion hole Enzyme promiscuity Catalytically perfect enzyme Coenzyme Cofactor Enzyme catalysis Enzyme kinetics Lineweaver–Burk plot Michaelis–Menten kinetics

Regulation	Allosteric regulation Cooperativity Enzyme inhibitor

Classification	EC number Enzyme superfamily Enzyme family List of enzymes

Types	EC1 Oxidoreductases(list) EC2 Transferases(list) EC3 Hydrolases(list) EC4 Lyases(list) EC5 Isomerases(list) EC6 Ligases(list)

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