Aldos-2-ulose dehydratase

Aldos-2-ulose dehydratase
Identifiers
EC number	4.2.1.110
CAS number	101920-80-3
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Search PMC articles PubMed articles NCBI proteins

Aldos-2-ulose dehydratase (EC 4.2.1.110, pyranosone dehydratase, AUDH, 1,5-anhydro-D-fructose dehydratase (microthecin-forming)) is an enzyme with systematic name 1,5-anhydro-D-fructose hydro-lyase (microthecin-forming).^{[1][2][3][4][5]} This enzyme catalyses the following chemical reaction

1,5-anhydro-D-fructose $\rightleftharpoons$ 2-hydroxy-2-(hydroxymethyl)-2H-pyran-3(6H)-one + H₂O (overall reaction)

(1a) 1,5-anhydro-D-fructose $\rightleftharpoons$ 1,5-anhydro-4-deoxy-D-glycero-hex-3-en-2-ulose + H₂O

(1b) 1,5-anhydro-4-deoxy-D-glycero-hex-3-en-2-ulose $\rightleftharpoons$ 2-hydroxy-2-(hydroxymethyl)-2H-pyran-3(6H)-one

This enzyme catalyses two of the steps in the anhydrofructose pathway.

References

1. Yu, S. and Fiskesund, R. (2006). "The anhydrofructose pathway and its possible role in stress response and signaling". Biochim. Biophys. Acta 1760: 1314–1322. doi:10.1016/j.bbagen.2006.05.007. PMID 16822618.
2. Yu, S. (2005). "Enzymatic description of the anhydrofructose pathway of glycogen degradation. II. Gene identification and characterization of the reactions catalyzed by aldos-2-ulose dehydratase that converts 1,5-anhydro-D-fructose to microthecin with ascopyrone M as the intermediate". Biochim. Biophys. Acta 1723: 63–73. doi:10.1016/j.bbagen.2005.01.004. PMID 15716041.
3. Broberg, A., Kenne, L. and Pedersén, M. (1996). "Presence of microthecin in the red alga Gracilariopsis lemaneiformis and its formation from 1,5-anhydro-D-fructose". Phytochemistry 41: 151–154. doi:10.1016/0031-9422(95)00587-0.
4. Gabriel, J., Volc, J., Sedmera, P., Daniel, G. and Kubátová, E. (1993). "Pyranosone dehydratase from the basidiomycete Phanerochaete chrysosporium: improved purification, and identification of 6-deoxy-D-glucosone and D-xylosone reaction products". Arch. Microbiol. 160 (1): 27–34. doi:10.1007/BF00258142. PMID 8352649.
5. Yu, S., Refdahl, C. and Lundt, I. (2004). "Enzymatic description of the anhydrofructose pathway of glycogen degradation; I. Identification and purification of anhydrofructose dehydratase, ascopyrone tautomerase and α-1,4-glucan lyase in the fungus Anthracobia melaloma". Biochim. Biophys. Acta 1672: 120–129. doi:10.1016/j.bbagen.2004.03.004. PMID 15110094.

External links

• Aldos-2-ulose dehydratase at the US National Library of Medicine Medical Subject Headings (MeSH)