Alphapapillomavirus

Alphapapillomavirus
Virus classification
Group:	Group I (dsDNA)
Family:	Papillomaviridae
Genus:	Alphapapillomavirus
Type Species
Alphapapillomavirus 1

Alphapapillomavirus is a genus of viruses, in the family Papillomaviridae. Human and monkeys serve as natural hosts. There are currently 14 species in this genus including the type species Alphapapillomavirus 1. Diseases associated with this genus include: warts, papilloma, malignant tumours. Genital-type, high-risk of malignancy (cervical cancer): HPV-16, 18. Genital-type, low-risk of malignancy (genital warts): HPV-6, 11.^[1][2]

Taxonomy

Group: dsDNA

Order: Unassigned

• Family: Papillomaviridae

  • Genus: Alphapapillomavirus 

    • Alphapapillomavirus 1
    • Alphapapillomavirus 2
    • Alphapapillomavirus 3
    • Alphapapillomavirus 4
    • Alphapapillomavirus 5
    • Alphapapillomavirus 6
    • Alphapapillomavirus 7
    • Alphapapillomavirus 8
    • Alphapapillomavirus 9
    • Alphapapillomavirus 10
    • Alphapapillomavirus 11
    • Alphapapillomavirus 12
    • Alphapapillomavirus 13
    • Alphapapillomavirus 14

^[2]

Structure

Viruses in Alphapapillomavirus are non-enveloped, with icosahedral geometries, and T=7 symmetry. The diameter is around 60 nm. Genomes are circular, around 8kb in length.^[1]

Genus	Structure	Symmetry	Capsid	Genomic Arrangement	Genomic Segmentation
Alphapapillomavirus	Icosahedral	T=7	Non-Enveloped	Circular	Monopartite

Life Cycle

Viral replication is nuclear. Entry into the host cell is achieved by attachment of the viral proteins to host receptors, which mediates endocytosis. Replication follows the dsDNA bidirectional replication model. Dna templated transcription, with some alternative splicing mechanism is the method of transcription. Translation takes place by leaky scanning, and ribosomal shunting. The virus exits the host cell by nuclear envelope breakdown. Humans and monkeys serve as the natural host. Transmission routes are sexual and contact.^[1]

Genus	Host Details	Tissue Tropism	Entry Details	Release Details	Replication Site	Assembly Site	Transmission
Alphapapillomavirus	Humans; monkeys	Epithelial: mucous; epithelial: skin	Cell receptor endocytosis	Lysis	Nucleus	Nucleus	Sex; contact

References

1. "Viral Zone". ExPASy. Retrieved 12 June 2015.
2. ICTV. "Virus Taxonomy: 2014 Release". Retrieved 12 June 2015.

External links

• Viralzone: Alphapapillomavirus
• ICTV