Amanullin
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| Names | |
|---|---|
| Other names
3-Isoleucine-alpha-amanitin | |
| Identifiers | |
21803-57-6  | |
| ChemSpider | 102814 |
| Jmol interactive 3D | Image Image |
| PubChem | 114856 |
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| Properties | |
| C39H54N10O12S | |
| Molar mass | 886.86 g/mol |
| Appearance | Colorless, crystalline solid |
| Soluble | |
| Solubility in ethanol, methanol | Soluble |
| Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). | |
verify (what is  ?) | |
| Infobox references | |
Amanullin is a cyclic nonribosomal peptide. It is an amatoxin, all of which are found in several members of the Amanita genus of mushrooms. The oral LD50 of amanullin is approximately 20 mg/kg in mice, however it is non-toxic in humans.
Toxicology
Like other amatoxins, amanullin is an inhibitor of RNA polymerase II. Amanullin has a species dependent and specific attraction to the enzyme RNA polymerase II. Upon ingestion, it binds to the RNA polymerase II enzyme, effectively causing cytolysis of hepatocytes (liver cells).[1]
See also
References
- ↑ Cochet-Meilhac M, Chambon P (June 1974). "Animal DNA-dependent RNA polymerases. 11. Mechanism of the inhibition of RNA polymerases B by amatoxins". Biochim. Biophys. Acta 353 (2): 160–84. doi:10.1016/0005-2787(74)90182-8. PMID 4601749.
External links
- Amatoxins REVISED
- Poisonous Mushrooms (German)
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