Ananain

Ananain

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Ananain (EC 3.4.22.31, stem bromelain, fruit bromelain) is an enzyme.^[1]^[2] This enzyme catalyses the following chemical reaction

Hydrolysis of proteins with broad specificity for peptide bonds. Best reported small molecule substrate Bz-Phe-Val-Arg-NHMec

This enzyme is isolated from stem of pineapple plant, Ananas comosus.

References

↑ Rowan, A.D., Buttle, D.J. and Barrett, A.J. (1988). "Ananain: a novel cysteine proteinase found in pineapple stem". Arch. Biochem. Biophys. 267: 262–270. doi:10.1016/0003-9861(88)90031-8. PMID 3196029.
↑ Rowan, A.D., Buttle, D.J. and Barrett, A.J. (1990). "The cysteine proteinases of the pineapple plant". Biochem. J. 266: 869–875. PMID 2327970.

External links

Ananain at the US National Library of Medicine Medical Subject Headings (MeSH)

Proteases: cysteine proteases (EC 3.4.22)

Caspase	Caspase 1 Caspase 2 Caspase 3 Caspase 4 Caspase 5 Caspase 6 Caspase 7 Caspase 8 Caspase 9 Caspase 10 Caspase 12 Caspase 13 Caspase 14

Fruit-derived	Papain Ficain Bromelain Actinidain

Calpain	CAPN1 CAPN2 CAPN3 CAPN5 CAPN6 CAPN7 CAPN8 CAPN9 CAPN10 CAPN11 CAPN12 CAPN13 CAPN14 CAPNS1 CAPNS2

Cathepsin	B C F H K L1/L2 O S W Z

Other	Clostripain Cancer procoagulant Separase Autophagin Cruzipain

Proteins: enzymes

Activity	Active site Binding site Catalytic triad Oxyanion hole Enzyme promiscuity Catalytically perfect enzyme Coenzyme Cofactor Enzyme catalysis Enzyme kinetics Lineweaver–Burk plot Michaelis–Menten kinetics

Regulation	Allosteric regulation Cooperativity Enzyme inhibitor

Classification	EC number Enzyme superfamily Enzyme family List of enzymes

Types	EC1 Oxidoreductases(list) EC2 Transferases(list) EC3 Hydrolases(list) EC4 Lyases(list) EC5 Isomerases(list) EC6 Ligases(list)

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