Atrolysin E

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Atrolysin E (EC 3.4.24.44, Crotalus atrox metalloendopeptidase e, hemorrhagic toxin e) is an enzyme.^[1]^[2]^[3] This enzyme catalyses the following chemical reaction

Cleavage of Asn³-Gln, Ser⁹-His and Ala¹⁴-Leu bonds in insulin B chain and Tyr¹⁴-Gln and Thr⁸-Ser in A chain. Cleaves type IV collagen at Ala⁷³-Gln in alpha1(IV) and at Gly⁷-Leu in alpha2(IV)

This endopeptidase is present in the venom of the western diamondback rattlesnake (Crotalus atrox).

References

↑ Bjarnason, J.B. and Tu, A.T. (1978). "Hemorrhagic toxins from western diamondback rattlesnake (Crotalus atrox) venom: isolation and characterization of five toxins and the role of zinc in hemorrhagic toxin e". Biochemistry 17: 3395–3404. doi:10.1021/bi00609a033. PMID 210790.
↑ Bjarnason, J.B. and Fox, J.W. (1983). "Proteolytic specificity and cobalt exchange of hemorrhagic toxin e, a zinc protease isolated from the venom of the western diamondback rattlesnake (Crotalus atrox)". Biochemistry 22 (16): 3770–3778. doi:10.1021/bi00285a009. PMID 6351911.
↑ Baramova, E.N., Shannon, J.D., Bjarnason, J.B. and Fox, J.W. (1990). "Identification of the cleavave sites by a hemorrhagic metalloproteinase in type IV collagen". Matrix 10 (2): 91–97. doi:10.1016/s0934-8832(11)80175-7. PMID 2374521.

External links

Atrolysin E at the US National Library of Medicine Medical Subject Headings (MeSH)

Proteases: metalloendopeptidases (EC 3.4.24)

ADAM proteins	Alpha secretases ADAM9 ADAM10 ADAM17 ADAM19 ADAM2 ADAM7 ADAM8 ADAM11 ADAM12 ADAM15 ADAM18 ADAM22 ADAM23 ADAM28 ADAM33 ADAMTS1 ADAMTS2 ADAMTS3 ADAMTS4 ADAMTS5 ADAMTS8 ADAMTS9 ADAMTS10 ADAMTS12 ADAMTS13

Matrix metalloproteinases	Collagenases MMP1 MMP8 Gelatinases MMP2 MMP9 MMP3 MMP7 MMP10 MMP11 MMP12 MMP13 MMP14 MMP15 MMP16 MMP17 MMP19 MMP20 MMP21 MMP23A MMP23B MMP24 MMP25 MMP26 MMP27 MMP28

Other	Neprilysin Procollagen peptidase Thermolysin Pregnancy-associated plasma protein A Bone morphogenetic protein 1 Lysostaphin Insulin-degrading enzyme ZMPSTE24

Enzymes

Activity	Active site Binding site Catalytic triad Oxyanion hole Enzyme promiscuity Catalytically perfect enzyme Coenzyme Cofactor Enzyme catalysis Enzyme kinetics Lineweaver–Burk plot Michaelis–Menten kinetics

Regulation	Allosteric regulation Cooperativity Enzyme inhibitor

Classification	EC number Enzyme superfamily Enzyme family List of enzymes

Types	EC1 Oxidoreductases(list) EC2 Transferases(list) EC3 Hydrolases(list) EC4 Lyases(list) EC5 Isomerases(list) EC6 Ligases(list)

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