Attention deficit hyperactivity disorder

"ADD" and "A.D.H.D." redirect here. For other uses, see ADD (disambiguation) and A.D.H.D. (disambiguation).

Attention deficit hyperactivity disorder

An image of children

Children with ADHD find it more difficult to focus and to complete their schoolwork.
Classification and external resources
Synonyms attention deficit disorder, hyperkinetic disorder (ICD-10)
Specialty Psychiatry
ICD-10 F90
ICD-9-CM 314.00, 314.01
OMIM 143465
DiseasesDB 6158
MedlinePlus 001551
eMedicine med/3103 ped/177
Patient UK Attention deficit hyperactivity disorder
MeSH D001289

Attention deficit hyperactivity disorder (ADHD) is a psychiatric disorder of the neurodevelopmental type.[1][2] It characterized by problems paying attention, excessive activity, or difficulty controlling behavior which is not appropriate for a person's age.[3] These symptoms begin by age six to twelve, are present for more than six months, and cause problems in at least two settings (such as school, home, or recreational activities).[4][5] In children, problems paying attention may result in poor school performance.[3] Although it causes impairment, particularly in modern society, many children have a good attention span for tasks they find interesting.[6]

Despite being the most commonly studied and diagnosed psychiatric disorder in children and adolescents, the cause is unknown in the majority of cases.[7] The World Health Organization estimated that it affected about 39 million people as of 2013.[8] It affects about 5–7% of children when diagnosed via the DSM-IV criteria[9][10] and 1–2% when diagnosed via the ICD-10 criteria.[11] Rates are similar between countries and depend mostly on how it is diagnosed.[12] ADHD is diagnosed approximately three times more in boys than in girls.[13][14] About 30–50% of people diagnosed in childhood continue to have symptoms into adulthood and between 2–5% of adults have the condition.[15][16][17] The condition can be difficult to tell apart from other disorders as well as to distinguish from high levels of activity that are still within the normal-range.[5]

ADHD management recommendations vary by country and usually involve some combination of counseling, lifestyle changes, and medications.[3] The British guideline only recommends medications as a first-line treatment in children who have severe symptoms and for medication to be considered in those with moderate symptoms who either refuse or fail to improve with counseling.[18] Canadian and American guidelines recommend that medications and behavioral therapy be used together as a first-line therapy, except in preschool-aged children.[19][20] Stimulant therapy is not recommended as a first-line therapy in preschool-aged children in either guideline.[18][20] Treatment with stimulants is effective for up to 14 months; however, its long term effectiveness is unclear.[18][21][22][23] Adolescents and adults tend to develop coping skills which make up for some or all of their impairments.[24]

The medical literature has described symptoms similar to ADHD since the 19th century.[25] ADHD, its diagnosis, and its treatment have been considered controversial since the 1970s.[26] The controversies have involved clinicians, teachers, policymakers, parents, and the media. Topics include ADHD's causes and the use of stimulant medications in its treatment.[27] Most healthcare providers accept ADHD as a genuine disorder, and the debate in the scientific community mainly centers on how it is diagnosed and treated.[28][29][30] The condition was officially known as attention deficit disorder (ADD) from 1980 to 1987 while before this it was known as hyperkinetic reaction of childhood.[31][32]

Signs and symptoms

Video explaining ADHD

Inattention, hyperactivity (restlessness in adults), disruptive behavior, and impulsivity are common in ADHD.[33][34] Academic difficulties are frequent as are problems with relationships.[33] The symptoms can be difficult to define as it is hard to draw a line at where normal levels of inattention, hyperactivity, and impulsivity end and significant levels requiring interventions begin.[35]

According to the DSM-5, symptoms must be present for six months or more to a degree that is much greater than others of the same age[10] and they must cause significant problems functioning in at least two settings (e.g., social, school/work, or home).[10] The full criteria must have been met prior to age 12 in order to receive a diagnosis of ADHD.[10]

ADHD is divided into three subtypes: predominantly inattentive, predominantly hyperactive-impulsive, and combined type.[35][10]

An individual with ADHD inattentive type has most or all of following symptoms, excluding situations where these symptoms are better explained by another psychiatric or medical condition:[36][10]

An individual with ADHD hyperactive/impulsive type has most or all of the following symptoms, excluding situations where these symptoms are better explained by another psychiatric or medical condition:[36][10]

Symptoms of hyperactivity tend to go away with age and turn into "inner restlessness" in teens and adults with ADHD.[15]

People with ADHD are more likely to have problems with social skills, such as social interaction and forming and maintaining friendships. This is true for all subtypes. About half of children and adolescents with ADHD experience social rejection by their peers compared to 10–15% of non-ADHD children and adolescents. People with attention deficits are prone to having difficulty processing verbal and nonverbal language which can negatively affect social interaction. They also may drift off during conversations, and miss social cues.[37]

Difficulties managing anger are more common in children with ADHD[38] as are poor handwriting[39] and delays in speech, language and motor development.[40][41] Although it causes significant impairment, particularly in modern society, many children with ADHD have a good attention span for tasks they find interesting.[6]

Associated disorders

In children ADHD occurs with other disorders about ⅔ of the time.[6] Some commonly associated conditions include:

There is an association with persistent bed wetting,[58] language delay,[59] and developmental coordination disorder (DCD).[60] Language delays can include auditory processing disorders such as short-term auditory memory weakness, difficulty following instructions, slow speed of processing spoken language, and difficulties listening in distracting environments.[61]

Cause

The cause of most cases of ADHD is unknown; however, it is believed to involve interactions between genetic and environmental factors.[62][63] Certain cases are related to previous infection of or trauma to the brain.[62]

Genetics

Twin studies indicate that the disorder is often inherited from one's parents with genetics determining about 75% of cases.[18][64][65] Siblings of children with ADHD are three to four times more likely to develop the disorder than siblings of children without the disorder.[66] Genetic factors are also believed to be involved in determining whether ADHD persists into adulthood.[67]

Typically, a number of genes are involved, many of which directly affect dopamine neurotransmission.[68][69] Those involved with dopamine include DAT, DRD4, DRD5, TAAR1, MAOA, COMT, and DBH.[69][70][71] Other genes associated with ADHD include SERT, HTR1B, SNAP25, GRIN2A, ADRA2A, TPH2, and BDNF.[68][69] A common variant of a gene called LPHN3 is estimated to be responsible for about 9% of cases and when this variant is present, people are particularly responsive to stimulant medication.[72] The 7 repeat variant of dopamine receptor D4 (DRD4–7R) causes increased inhibitory effects induced by dopamine and is associated with ADHD. The DRD4 receptor is a G protein-coupled receptor that inhibits adenylyl cyclase. The DRD4–7R mutation results in a wide range of behavioral phenotypes, including ADHD symptoms reflecting split attention.[73]

As ADHD is common, natural selection likely favored the traits, at least individually, and they may have provided a survival advantage.[74] For example, some women may be more attracted to males who are risk takers, increasing the frequency of genes that predispose to ADHD in the gene pool.[75] As it is more common in children of anxious or stressed mothers, some argue that ADHD is an adaptation that helps children face a stressful or dangerous environment with, for example, increased impulsivity and exploratory behavior.[76]

Hyperactivity might have been beneficial, from an evolutionary perspective, in situations involving risk, competition, or unpredictable behavior (i.e. exploring new areas or finding new food sources). In these situations, ADHD could have been beneficial to society as a whole even while being harmful to the individual.[75] Additionally, in certain environments it may have offered advantages to the individuals themselves, such as quicker response to predators or superior hunting skills.[77]

People with Down syndrome are more likely to have ADHD.[78]

Environment

In addition to genetics, some environmental factors might play a role.[79] Alcohol intake during pregnancy can cause fetal alcohol spectrum disorders which can include ADHD or symptoms like it.[80] Children exposed to certain toxic substances, such as lead or polychlorinated biphenyls, may develop problems which resemble ADHD.[81][82] Exposure to the organophosphate insecticides chlorpyrifos and dialkyl phosphate is associated with an increased risk; however, the evidence is not conclusive.[83] Exposure to tobacco smoke during pregnancy can cause problems with central nervous system development and can increase the risk of ADHD.[84][81]

Extreme premature birth, very low birth weight, and extreme neglect, abuse, or social deprivation also increase the risk[81][85] as do certain infections during pregnancy, at birth, and in early childhood. These infections include, among others, various viruses (measles, varicella zoster encephalitis, rubella, enterovirus 71).[86] At least 30% of children with a traumatic brain injury later develop ADHD[87] and about 5% of cases are due to brain damage.[88]

Some studies suggest that in a minority of children, artificial food dyes or preservative may be associated with an increased prevalence of ADHD or ADHD-like symptoms[81][89] but the evidence is weak and may only apply to children with food sensitivities.[89][90][91] The United Kingdom and the European Union have put in place regulatory measures based on these concerns.[92] In a minority of children, intolerances or allergies to certain foods may worsen ADHD symptoms.[93]

Research does not support popular beliefs that ADHD is caused by eating too much refined sugar, watching too much television, parenting, poverty or family chaos; however, they might worsen ADHD symptoms in certain people.[94]

Society

The diagnosis of ADHD can represent family dysfunction or a poor educational system rather than an individual problem.[95] Some cases may be explained by increasing academic expectations, with a diagnosis being a method for parents in some countries to get extra financial and educational support for their child.[88] The youngest children in a class have been found to be more likely to be diagnosed as having ADHD possibly due to their being developmentally behind their older classmates.[96][97] Behaviors typical of ADHD occurs more commonly in children who have experienced violence and emotional abuse.[18]

According to social construction theory it is societies that determine the boundary between normal and abnormal behavior. Members of society, including physicians, parents, and teachers, determine which diagnostic criteria are used and, thus, the number of people affected.[98] This leads to the current situation where the DSM-IV arrives at levels of ADHD three to four times higher than those obtained with the ICD-10.[14] Thomas Szasz, a supporter of this theory, has argued that ADHD was "invented and not discovered."[99][100]

Pathophysiology

Current models of ADHD suggest that it is associated with functional impairments in some of the brain's neurotransmitter systems, particularly those involving dopamine and norepinephrine.[101][102] The dopamine and norepinephrine pathways that originate in the ventral tegmental area and locus coeruleus project to diverse regions of the brain and govern a variety of cognitive processes.[101][103] The dopamine pathways and norepinephrine pathways which project to the prefrontal cortex and striatum are directly responsible for modulating executive function (cognitive control of behavior), motivation, reward perception, and motor function;[101][102][103] these pathways are known to play a central role in the pathophysiology of ADHD.[101][103][104][105] Larger models of ADHD with additional pathways have been proposed.[102][104][105]

Brain structure

In children with ADHD, there is a general reduction of volume in certain brain structures, with a proportionally greater decrease in the volume in the left-sided prefrontal cortex.[102][106] The posterior parietal cortex also shows thinning in ADHD individuals compared to controls.[102] Other brain structures in the prefrontal-striatal-cerebellar and prefrontal-striatal-thalamic circuits have also been found to differ between people with and without ADHD.[102][104][105]

Neurotransmitter pathways

Previously it was thought that the elevated number of dopamine transporters in people with ADHD was part of the pathophysiology but it appears that the elevated numbers are due to adaptation to exposure to stimulants.[107] Current models involve the mesocorticolimbic dopamine pathway and the locus coeruleus-noradrenergic system.[101][102][103] ADHD psychostimulants possess treatment efficacy because they increase neurotransmitter activity in these systems.[102][103][108] There may additionally be abnormalities in serotoninergic and cholinergic pathways.[108][109] Neurotransmission of glutamate, a cotransmitter with dopamine in the mesolimbic pathway,[110] seems to be also involved.[111]

Executive function and motivation

The symptoms of ADHD arise from a deficiency in certain executive functions (e.g., attentional control, inhibitory control, and working memory).[56][102][103] Executive functions are a set of cognitive processes that are required to successfully select and monitor behaviors that facilitate the attainment of one's chosen goals.[56][103] The executive function impairments that occur in ADHD individuals result in problems with staying organized, time keeping, excessive procrastination, maintaining concentration, paying attention, ignoring distractions, regulating emotions, and remembering details.[56][102][103] People with ADHD appear to have unimpaired long-term memory, and deficits in long-term recall appear to be attributed to impairments in working memory.[56][112] The criteria for an executive function deficit are met in 30–50% of children and adolescents with ADHD.[113] One study found that 80% of individuals with ADHD were impaired in at least one executive function task, compared to 50% for individuals without ADHD.[114] Due to the rates of brain maturation and the increasing demands for executive control as a person gets older, ADHD impairments may not fully manifest themselves until adolescence or even early adulthood.[56]

ADHD has also been associated with motivational deficits in children.[115] Children with ADHD find it difficult to focus on long-term over short-term rewards, and exhibit impulsive behavior for short-term rewards.[115] In these individuals, a large amount of positive reinforcement effectively improves task performance.[115] ADHD stimulants may improve persistence in ADHD children as well.[115]

Diagnosis

ADHD is diagnosed by an assessment of a person's childhood behavioral and mental development, including ruling out the effects of drugs, medications and other medical or psychiatric problems as explanations for the symptoms.[18] It often takes into account feedback from parents and teachers[5] with most diagnoses begun after a teacher raises concerns.[88] It may be viewed as the extreme end of one or more continuous human traits found in all people.[18] Whether someone responds to medications does not confirm or rule out the diagnosis. As imaging studies of the brain do not give consistent results between individuals, they are only used for research purposes and not diagnosis.[116]

In North America, DSM-5 criteria are used for diagnosis, while European countries usually use the ICD-10. With the DSM-IV criteria a diagnosis of ADHD is 3–4 times more likely than with the ICD-10 criteria.[14] It is classified as neurodevelopmental psychiatric disorder.[15][2] Additionally, it is classified as a disruptive behavior disorder along with oppositional defiant disorder, conduct disorder, and antisocial personality disorder.[117] A diagnosis does not imply a neurological disorder.[18]

Associated conditions that should be screened for include anxiety, depression, oppositional defiant disorder, conduct disorder, and learning and language disorders. Other conditions that should be considered are other neurodevelopmental disorders, tics, and sleep apnea.[118]

Diagnosis of ADHD using quantitative electroencephalography (QEEG) is an ongoing area of investigation, although the value of QEEG in ADHD is currently unclear.[119][120] In the United States, the Food and Drug Administration has approved the use of QEEG to evaluate the morbidity of ADHD.[121]

Diagnostic and Statistical Manual

As with many other psychiatric disorders, formal diagnosis is made by a qualified professional based on a set number of criteria. In the United States, these criteria are defined by the American Psychiatric Association in the DSM. Based on the DSM criteria, there are three sub-types of ADHD:[10]

  1. ADHD predominantly inattentive type (ADHD-PI) presents with symptoms including being easily distracted, forgetful, daydreaming, disorganization, poor concentration, and difficulty completing tasks.[4][10]
  2. ADHD, predominantly hyperactive-impulsive type presents with excessive fidgetiness and restlessness, hyperactivity, difficulty waiting and remaining seated, immature behavior; destructive behaviors may also be present.[4][10]
  3. ADHD, combined type is a combination of the first two subtypes.[4][10]

This subdivision is based on presence of at least six out of nine long-term (lasting at least six months) symptoms of inattention, hyperactivity–impulsivity, or both.[122] To be considered, the symptoms must have appeared by the age of six to twelve and occur in more than one environment (e.g. at home and at school or work).[4] The symptoms must be not appropriate for a child of that age[4][123] and there must be evidence that it is causing social, school or work related problems.[122]

International Classification of Diseases

In the ICD-10, the symptoms of "hyperkinetic disorder" are analogous to ADHD in the DSM-5. When a conduct disorder (as defined by ICD-10)[40] is present, the condition is referred to as hyperkinetic conduct disorder. Otherwise, the disorder is classified as disturbance of activity and attention, other hyperkinetic disorders or hyperkinetic disorders, unspecified. The latter is sometimes referred to as hyperkinetic syndrome.[40]

Adults

Further information: Adult ADHD

Adults with ADHD are diagnosed under the same criteria, including that their signs must have been present by the age of six to twelve. Questioning parents or guardians as to how the person behaved and developed as a child may form part of the assessment; a family history of ADHD also adds weight to a diagnosis.[15] While the core symptoms of ADHD are similar in children and adults they often present differently in adults than in children, for example excessive physical activity seen in children may present as feelings of restlessness and constant mental activity in adults.[15]

Differential diagnosis

ADHD Symptoms which are related to other Disorders[124]
Depression Anxiety disorder Bipolar disorder
  • persistent feeling of anxiety
  • irritability
  • occasional feelings of panic or fear
  • being hyperalert
  • inability to pay attention
  • tire easily
  • low tolerance for stress
  • difficulty maintaining attention
in manic state
in depressive state
  • same symptoms as in depression section

Symptoms of ADHD such as low mood and poor self-image, mood swings, and irritability can be confused with dysthymia, cyclothymia or bipolar disorder as well as with borderline personality disorder.[15] Some symptoms that are due to anxiety disorders, antisocial personality disorder, developmental disabilities or mental retardation or the effects of substance abuse such as intoxication and withdrawal can overlap with some ADHD. These disorders can also sometimes occur along with ADHD. Medical conditions which can cause ADHD type symptoms include: hyperthyroidism, seizure disorder, lead toxicity, hearing deficits, hepatic disease, sleep apnea, drug interactions, untreated celiac disease, and head injury.[24][125]

Primary sleep disorders may affect attention and behavior and the symptoms of ADHD may affect sleep.[126] It is thus recommended that children with ADHD be regularly assessed for sleep problems.[127] Sleepiness in children may result in symptoms ranging from the classic ones of yawning and rubbing the eyes, to hyperactivity and inattentiveness.[128] Obstructive sleep apnea can also cause ADHD type symptoms.[128]

Management

The management of ADHD typically involves counseling or medications either alone or in combination. While treatment may improve long-term outcomes, it does not get rid of negative outcomes entirely.[129] Medications used include stimulants, atomoxetine, alpha-2 adrenergic receptor agonists, and sometimes antidepressants.[48][108]

Behavioral therapies

There is good evidence for the use of behavioral therapies in ADHD[130] and they are the recommended first line treatment in those who have mild symptoms or are preschool-aged.[131] Psychological therapies used include: psychoeducational input, behavior therapy, cognitive behavioral therapy (CBT), interpersonal psychotherapy, family therapy, school-based interventions, social skills training, behavioral peer intervention, organization training,[132] parent management training,[18] and neurofeedback.[133] Behavior modification and neurofeedback have the best support.[134]

Parent training and education have been found to have short-term benefits.[135][136] There is little high quality research on the effectiveness of family therapy for ADHD, but the evidence that exists shows that it is similar to community care and better than a placebo.[137] Several ADHD specific support groups exist as informational sources and may help families cope with ADHD.[138]

Training in social skills, behavioral modification and medication may have some limited beneficial effects. The most important factor in reducing later psychological problems, such as major depression, criminality, school failure, and substance use disorders is formation of friendships with people who are not involved in delinquent activities.[139]

Regular physical exercise, particularly aerobic exercise, is an effective add on treatment for ADHD, although the best type and intensity is not currently known.[140][141] In particular, physical exercise has been shown to result in better behavior and motor abilities without causing any side effects.[140][141]

Medication

A picture of a Ritalin packet
Methylphenidate (Ritalin) 10 mg tablets

Stimulant medications are the pharmaceutical treatment of choice.[142][143] They have at least some effect in the short term in about 80% of people.[23] Methylphenidate appears to improve symptoms as reported by teachers and parents.[144]

There are a number of non-stimulant medications, such as atomoxetine, bupropion, guanfacine, and clonidine that may be used as alternatives.[142] There are no good studies comparing the various medications; however, they appear more or less equal with respect to side effects.[145] Stimulants appear to improve academic performance while atomoxetine does not.[146] There is little evidence on their effects on social behaviors.[145] Medications are not recommended for preschool children, as the long-term effects in this age group are not known.[18][147] The long-term effects of stimulants generally are unclear with one study finding benefit, another finding no benefit and a third finding evidence of harm.[148] Magnetic resonance imaging studies suggest that long-term treatment with amphetamine or methylphenidate decreases abnormalities in brain structure and function found in subjects with ADHD.[149][150][151] Atomoxetine, due to its lack of addiction liability, may be preferred in those who are at risk of recreational or compulsive stimulant use.[15] Guidelines on when to use medications vary by country, with the United Kingdom's National Institute for Health and Care Excellence recommending use only in severe cases, while most United States guidelines recommend medications in most age groups.[19]

While stimulants and atomoxetine are usually safe, there are side-effects and contraindications to their use.[142] A large overdose on ADHD stimulants is commonly associated with symptoms such as stimulant psychosis and mania;[152] although very rare, at therapeutic doses these events appear to occur in approximately 0.1% of individuals within the first several weeks after starting amphetamine or methylphenidate therapy.[153][152][154] Administration of an antipsychotic medication has been found to effectively resolve the symptoms of acute amphetamine psychosis.[152] Regular monitoring has been recommended in those on long-term treatment.[155] Stimulant therapy should be stopped periodically to assess for continuing need for medication.[156] Long-term misuse of stimulant medications at doses above the therapeutic range for ADHD treatment is associated with addiction and dependence;[157][158] several studies indicate that untreated ADHD is associated with elevated risk of substance use disorders and conduct disorders.[157] The use of stimulants appears to either reduce this risk or have no effect on it.[15][157] The safety of these medications in pregnancy is unclear.[159]

Diet

Dietary modifications may be of benefit to some children with ADHD.[160] A 2013 meta-analysis found less than a third of children with ADHD see some improvement in symptoms with free fatty acid supplementation or decreased eating of artificial food coloring.[90] These benefits may be limited to children with food sensitivities or those who are simultaneously being treated with ADHD medications.[90] This review also found that evidence does not support removing other foods from the diet to treat ADHD.[90] A 2014 review found that an elimination diet results in a small overall benefit.[93] A 2016 review did not support a clear link between celiac disease and ADHD, and stated that routine screening for celiac disease in people with ADHD and the use of a gluten-free diet as standard ADHD treatment are discouraged.[125] Iron, magnesium and iodine may also have an effect on ADHD symptoms.[161] There is a small amount of evidence that lower tissue zinc levels may be associated with ADHD.[162] In the absence of a demonstrated zinc deficiency (which is rare outside of developing countries), zinc supplementation is not recommended as treatment for ADHD.[163] There is evidence of a modest benefit of omega 3 fatty acid supplementation, but it is not recommended in place of traditional medication.[164]

Prognosis

An 8-year follow up of children diagnosed with ADHD (combined type) found that they often have difficulties in adolescence, regardless of treatment or lack thereof.[165] In the US, fewer than 5% of individuals with ADHD get a college degree,[166] compared to 28% of the general population aged 25 years and older.[167] The proportion of children meeting criteria for ADHD drops by about half in the three years following the diagnosis and this occurs regardless of treatments used.[168][169] ADHD persists into adulthood in about 30–50% of cases.[16] Those affected are likely to develop coping mechanisms as they mature, thus compensating for their previous symptoms.[24]

Epidemiology

ADHD is estimated to affect about 6–7% of people aged 18 and under when diagnosed via the DSM-IV criteria.[9] When diagnosed via the ICD-10 criteria rates in this age group are estimated at 1–2%.[11] Children in North America appear to have a higher rate of ADHD than children in Africa and the Middle East; this is believed to be due to differing methods of diagnosis rather than a difference in underlying frequency.[170] If the same diagnostic methods are used, the rates are more or less the same between countries.[12] It is diagnosed approximately three times more often in boys than in girls.[13][14] This difference between sexes may reflect either a difference in susceptibility or that females with ADHD are less likely to be diagnosed than males.[171]

Rates of diagnosis and treatment have increased in both the United Kingdom and the United States since the 1970s.[172] This is believed to be primarily due to changes in how the condition is diagnosed[172] and how readily people are willing to treat it with medications rather than a true change in how common the condition is.[11] It is believed that changes to the diagnostic criteria in 2013 with the release of the DSM-5 will increase the percentage of people diagnosed with ADHD, especially among adults.[173]

History

Hyperactivity has long been part of the human condition. Sir Alexander Crichton describes "mental restlessness" in his book An inquiry into the nature and origin of mental derangement written in 1798.[174][175] ADHD was first clearly described by George Still in 1902.[172]

The terminology used to describe the condition has changed over time and has included: in the DSM-I (1952) "minimal brain dysfunction", in the DSM-II (1968) "hyperkinetic reaction of childhood", in the DSM-III (1980) "attention-deficit disorder (ADD) with or without hyperactivity".[172] In 1987 this was changed to ADHD in the DSM-III-R and the DSM-IV in 1994 split the diagnosis into three subtypes, ADHD inattentive type, ADHD hyperactive-impulsive type and ADHD combined type.[176] These terms were kept in the DSM-5 in 2013.[10] Other terms have included "minimal brain damage" used in the 1930s.[177]

The use of stimulants to treat ADHD was first described in 1937.[178] In 1934, Benzedrine became the first amphetamine medication approved for use in the United States.[179] Methylphenidate was introduced in the 1950s, and enantiopure dextroamphetamine in the 1970s.[172]

Society and culture

Controversies

ADHD, its diagnosis, and its treatment have been controversial since the 1970s.[26][27][180] The controversies involve clinicians, teachers, policymakers, parents, and the media. Positions range from the view that ADHD is within the normal range of behavior[18][181] to the hypothesis that ADHD is a genetic condition.[182] Other areas of controversy include the use of stimulant medications in children,[27][183] the method of diagnosis, and the possibility of overdiagnosis.[183] In 2012, the National Institute for Health and Care Excellence, while acknowledging the controversy, states that the current treatments and methods of diagnosis are based on the dominant view of the academic literature.[18] In 2014, Keith Conners, one of the early advocates for recognition of the disorder, spoke out against overdiagnosis in a New York Times article.[184] In contrast, a 2014 peer-reviewed medical literature review indicated that ADHD is underdiagnosed in adults.[17]

With widely differing rates of diagnosis across countries, states within countries, races, and ethnicities, some suspect factors other than the presence of the symptoms of ADHD are playing a role in diagnosis.[96] Some sociologists consider ADHD to be an example of the medicalization of deviant behavior, that is, the turning of the previously non-medical issue of school performance into a medical one.[26][88] Most healthcare providers accept ADHD as a genuine disorder, at least in the small number of people with severe symptoms.[88] Among healthcare providers the debate mainly centers on diagnosis and treatment in the much larger number of people with less severe symptoms.[29][30][88]

As of 2009, 8% of all United States Major League Baseball players had been diagnosed with ADHD, making the disorder common among this population. The increase coincided with the League's 2006 ban on stimulants, which has raised concern that some players are mimicking or falsifying the symptoms or history of ADHD to get around the ban on the use of stimulants in sport.[185]

Media commentary

A number of public figures have given controversial statements regarding ADHD. Tom Cruise has described the medications Ritalin (methylphenidate) and Adderall (an amphetamine formulation) as "street drugs".[186] Ushma S. Neill criticized this view, stating that the doses of stimulants used in the treatment of ADHD do not cause addiction and that there is some evidence of a reduced risk of later substance addiction in children treated with stimulants.[187] In the UK, Susan Greenfield spoke out publicly in 2007 in the House of Lords about the need for a wide-ranging inquiry into the dramatic increase in the diagnosis of ADHD, and possible causes. Her comments followed a BBC Panorama program that highlighted research that suggested medications are no better than other forms of therapy in the long term.[188] In 2010, the BBC Trust criticized the 2007 Panorama program for summarizing the research as showing "no demonstrable improvement in children's behaviour after staying on ADHD medication for three years" when in actuality "the study found that medication did offer a significant improvement over time" although the long-term benefits of medication were found to be "no better than children who were treated with behavior therapy."[189]

Special populations

Adults

It is estimated that between 2–5% of adults have ADHD.[15] Around 25-50% of children with ADHD continue to experience ADHD symptoms into adulthood, while the rest experiences fewer or no symptoms.[15][10] Most adults remain untreated.[190] Many have a disorganized life and use non-prescribed drugs or alcohol as a coping mechanism.[24] Other problems may include relationship and job difficulties, and an increased risk of criminal activities.[15] Associated mental health problems include: depression, anxiety disorder, and learning disabilities.[24]

Some ADHD symptoms in adults differ from those seen in children. While children with ADHD may climb and run about excessively, adults may experience an inability to relax, or they talk excessively in social situations. Adults with ADHD may start relationships impulsively, display sensation-seeking behavior, and be short-tempered. Addictive behavior such as substance abuse and gambling are common. The DSM-IV criteria have been criticized for not being appropriate for adults; those who present differently may lead to the claim that they outgrew the diagnosis.[15]

Children with high IQ scores

The diagnosis of ADHD and the significance of its impact on children with a high intelligence quotient (IQ) is controversial. Most studies have found similar impairments regardless of IQ, with higher rates of repeating grades and having social difficulties. Additionally, more than half of people with high IQ and ADHD experience major depressive disorder or oppositional defiant disorder at some point in their lives. Generalised anxiety disorder, separation anxiety disorder and social phobia are also more common. There is some evidence that individuals with high IQ and ADHD have a lowered risk of substance abuse and anti-social behavior compared to children with low and average IQ and ADHD. Children and adolescents with high IQ can have their level of intelligence mismeasured during a standard evaluation and may require more comprehensive testing.[191]

References

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  2. 1 2 Caroline, SC, ed. (2010). Encyclopedia of Cross-Cultural School Psychology. Springer Science & Business Media. p. 133. ISBN 9780387717982.
  3. 1 2 3 "Attention Deficit Hyperactivity Disorder". National Institute of Mental Health. Retrieved 5 March 2016.
  4. 1 2 3 4 5 6 "Symptoms and Diagnosis". Attention-Deficit / Hyperactivity Disorder (ADHD). Division of Human Development, National Center on Birth Defects and Developmental Disabilities, Centers for Disease Control and Prevention. 29 September 2014. Retrieved 3 November 2014.
  5. 1 2 3 Dulcan, MK; Lake, MB (2011). Concise Guide to Child and Adolescent Psychiatry (4th illustrated ed.). American Psychiatric Publishing. p. 34. ISBN 9781585624164.
  6. 1 2 3 Walitza, S; Drechsler, R; Ball, J (August 2012). "Das schulkind mit ADHS" [The school child with ADHD]. Ther Umsch (in German) 69 (8): 467–73. doi:10.1024/0040-5930/a000316. PMID 22851461.
  7. ↑ "Attention Deficit Hyperactivity Disorder (Easy-to-Read)". National Institute of Mental Health. 2013. Retrieved 5 March 2016.
  8. ↑ Global Burden of Disease Study 2013, Collaborators (5 June 2015). "Global, regional, and national incidence, prevalence, and years lived with disability for 301 acute and chronic diseases and injuries in 188 countries, 1990–2013: a systematic analysis for the Global Burden of Disease Study 2013.". Lancet (London, England). doi:10.1016/S0140-6736(15)60692-4. PMID 26063472.
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    Therapeutic (relatively low) doses of psychostimulants, such as methylphenidate and amphetamine, improve performance on working memory tasks both in normal subjects and those with ADHD. Positron emission tomography (PET) demonstrates that methylphenidate decreases regional cerebral blood flow in the dorsolateral prefrontal cortex and posterior parietal cortex while improving performance of a spatial working memory task. This suggests that cortical networks that normally process spatial working memory become more efficient in response to the drug. ... [It] is now believed that dopamine and norepinephrine, but not serotonin, produce the beneficial effects of stimulants on working memory. At abused (relatively high) doses, stimulants can interfere with working memory and cognitive control ... stimulants act not only on working memory function, but also on general levels of arousal and, within the nucleus accumbens, improve the saliency of tasks. Thus, stimulants improve performance on effortful but tedious tasks ... through indirect stimulation of dopamine and norepinephrine receptors.
    NOTE: VTA: ventral tegmental area
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    NOTE: DA: dopamine, LC: locus coeruleus, VTA: ventral tegmental area, 5HT: serotonin (5-hydroxytryptamine)
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