BCL2-like 1 (gene)

BCL2-like 1
PDB rendering based on 1af3.
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 1BXL​, 1G5J​, 1LXL​, 1MAZ​, 1R2D​, 1R2E​, 1R2G​, 1R2H​, 1R2I​, 1YSG​, 1YSI​, 1YSN​, 2B48​, 2LP8​, 2LPC​, 2M03​, 2M04​, 2ME8​, 2ME9​, 2MEJ​, 2O1Y​, 2O2M​, 2O2N​, 2P1L​, 2PON​, 2YJ1​, 2YQ6​, 2YQ7​, 2YXJ​, 3CVA​, 3FDL​, 3FDM​, 3INQ​, 3IO8​, 3PL7​, 3QKD​, 3R85​, 3SP7​, 3SPF​, 3WIZ​, 3ZK6​, 3ZLN​, 3ZLO​, 3ZLR​, 4A1U​, 4A1W​, 4AQ3​, 4BPK​, 4C52​, 4C5D​, 4CIN​, 4EHR​, 4HNJ​, 4IEH​, 4PPI​, 4TUH​
Identifiers
Symbols	BCL2L1 ; BCL-XL/S; BCL2L; BCLX; BCLXL; BCLXS; Bcl-X; PPP1R52; bcl-xL; bcl-xS
External IDs	OMIM: 600039 MGI: 88139 HomoloGene: 7639 ChEMBL: 4625 GeneCards: BCL2L1 Gene
Gene ontology Molecular function • protein binding • protein kinase binding • identical protein binding • protein homodimerization activity • protein heterodimerization activity • BH3 domain binding Cellular component • nucleus • nucleolus • cytoplasm • mitochondrion • mitochondrial outer membrane • mitochondrial inner membrane • mitochondrial matrix • centrosome • cytosol • integral component of membrane • cell junction • synaptic vesicle membrane • nuclear membrane • Bcl-2 family protein complex Biological process • cytokinesis • ovarian follicle development • in utero embryonic development • release of cytochrome c from mitochondria • endocytosis • apoptotic process • mitotic cell cycle checkpoint • germ cell development • spermatogenesis • cell proliferation • positive regulation of cell proliferation • male gonad development • intrinsic apoptotic signaling pathway in response to DNA damage • apoptotic mitochondrial changes • fertilization • negative regulation of autophagy • programmed cell death • suppression by virus of host apoptotic process • response to cytokine • nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway • growth • negative regulation of apoptotic process • negative regulation of neuron apoptotic process • innate immune response • response to cycloheximide • regulation of mitochondrial membrane permeability • neuron apoptotic process • regulation of mitochondrial membrane potential • cellular process regulating host cell cycle in response to virus • mitochondrion morphogenesis • cellular response to amino acid stimulus • cellular response to alkaloid • cellular response to gamma radiation • apoptotic process in bone marrow • negative regulation of establishment of protein localization to plasma membrane • negative regulation of release of cytochrome c from mitochondria • extrinsic apoptotic signaling pathway in absence of ligand • intrinsic apoptotic signaling pathway • hepatocyte apoptotic process • negative regulation of execution phase of apoptosis • negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage • negative regulation of anoikis • negative regulation of extrinsic apoptotic signaling pathway in absence of ligand • negative regulation of intrinsic apoptotic signaling pathway • positive regulation of intrinsic apoptotic signaling pathway Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	598	12048
Ensembl	ENSG00000171552	ENSMUSG00000007659
UniProt	Q07817	Q64373
RefSeq (mRNA)	NM_001191	NM_001289716
RefSeq (protein)	NP_001182	NP_001276645
Location (UCSC)	Chr 20: 31.66 – 31.72 Mb	Chr 2: 152.78 – 152.83 Mb
PubMed search

Bcl-2-like protein 1 is a protein that in humans is encoded by the BCL2L1 gene.^[1]

Function

The protein encoded by this gene belongs to the BCL-2 protein family. BCL-2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. The proteins encoded by this gene are located at the outer mitochondrial membrane, and have been shown to regulate outer mitochondrial membrane channel (VDAC) opening. VDAC regulates mitochondrial membrane potential, and thus controls the production of reactive oxygen species(ROS) and release of cytochrome C by mitochondria, both of which are the potent inducers of cell apoptosis. Two alternatively spliced transcript variants, which encode distinct isoforms, have been reported. The longer isoform (Bcl-xL) acts as an apoptotic inhibitor and the shorter form (Bcl-xS) acts as an apoptotic activator.^[2][3]

A LncRNA (Long non coding RNA, a RNA that acts without coding a protein) is involved with the alternative splicing between the two isoforms (BCL-XL and BCL-XS). This LncRNA is called INXS^[4][5] and acts as a pro-apoptotic agent, been downregulated in cancer cells.^[4]

Interactions

BCL2-like 1 (gene) has been shown to interact with:

• APAF1,^[6][7]
• BAK1,^{[8][9][10][11][12]}
• BCAP31,^[13]
• BCL2L11,^{[10][14][15][16]}
• BNIP3,^[17]
• BNIPL,^[18][19]
• BAD,^{[9][14][20][21][22][23][24][25][26][27][28]}
• BAX,^{[9][21][29][30]}
• BIK,^{[8][14][30][31]}
• Bcl-2,^[9][32]
• HRK,^[10][33][34]
• IKZF3,^[35]
• Noxa,^[14][36]
• PPP1CA,^[22]
• PSEN2^[37]
• RAD9A,^[8][20]
• RTN1,^[38]
• RTN4,^[38] and
• VDAC1.^{[39][40][41][42]}

References

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2. "Entrez Gene: BCL2L1 BCL2-like 1".
3. Boise LH, González-García M, Postema CE, Ding L, Lindsten T, Turka LA, Mao X, Nuñez G, Thompson CB (Aug 1993). "bcl-x, a bcl-2-related gene that functions as a dominant regulator of apoptotic cell death". Cell 74 (4): 597–608. doi:10.1016/0092-8674(93)90508-N. PMID 8358789.
4. DeOcesano-Pereira C, Amaral MS, Parreira KS, Ayupe AC, Jacysyn JF, Amarante-Mendes GP, Reis EM, Verjovski-Almeida S (Jul 2014). "Long non-coding RNA INXS is a critical mediator of BCL-XS induced apoptosis". Nucleic Acids Research 42 (13): 8343–55. doi:10.1093/nar/gku561. PMID 24992962.
5. "ABALON apoptotic BCL2L1-antisense long non-coding RNA [Homo sapiens (human)]". Gene. NCBI.
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22. Ayllón V, Cayla X, García A, Fleischer A, Rebollo A (Jul 2002). "The anti-apoptotic molecules Bcl-xL and Bcl-w target protein phosphatase 1alpha to Bad". European Journal of Immunology 32 (7): 1847–55. doi:10.1002/1521-4141(200207)32:7<1847::AID-IMMU1847>3.0.CO;2-7. PMID 12115603.
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28. Komatsu K, Wharton W, Hang H, Wu C, Singh S, Lieberman HB, Pledger WJ, Wang HG (Nov 2000). "PCNA interacts with hHus1/hRad9 in response to DNA damage and replication inhibition". Oncogene 19 (46): 5291–7. doi:10.1038/sj.onc.1203901. PMID 11077446.
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Further reading

• Ogata Y, Takahashi M (Sep 2003). "Bcl-xL as an antiapoptotic molecule for cardiomyocytes". Drug News & Perspectives 16 (7): 446–52. doi:10.1358/dnp.2003.16.7.829356. PMID 14668940.