Bacillolysin

Bacillolysin
Identifiers
EC number 3.4.24.28
CAS number 9080-56-2
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum

Bacillolysin (EC 3.4.24.28, Bacillus metalloendopeptidase, Bacillus subtilis neutral proteinase, anilozyme P 10, Bacillus metalloproteinase, Bacillus neutral proteinase, megateriopeptidase) is an enzyme.[1][2][3][4][5][6][7][8][9][10] This enzyme catalyses the following chemical reaction

Similar, but not identical, to that of thermolysin

This enzyme is present in many Bacillus species, including B. subtilis, B. amyloliquefaciens, B. megaterium, B. mesentericus, B. cereus and B. stearothermophilus.

References

  1. ↑ Morihara, K., Tsuzuki, H. and Oka, T. (1968). "Comparison of the specificities of various neutral proteinases from microorganisms". Arch. Biochem. Biophys. 123: 572–588. doi:10.1016/0003-9861(68)90179-3. PMID 4967801.
  2. ↑ Millet, J. and Acher, R. (1969). "Spécificité de la mégatériopeptidase: une amino-endopeptidase à caractère hydrophobe". Eur. J. Biochem. 9: 456–462. doi:10.1111/j.1432-1033.1969.tb00631.x. PMID 4980359.
  3. ↑ Feder, J., Keay, L., Garrett, L.R., Cirulis, N., Moseley, M.H. and Wildi, B.S. (1971). "Bacillus cereus neutral protease". Biochim. Biophys. Acta 251: 74–78. doi:10.1016/0005-2795(71)90061-4. PMID 5002444.
  4. ↑ Holmquist, B. and Vallee, B.L. (1976). "Esterase activity of zinc neutral proteases". Biochemistry 15: 101–107. doi:10.1021/bi00646a016. PMID 2276.
  5. ↑ Vasantha, N., Thompson, L.D., Rhodes, C., Banner, C., Nagle, J. and Filpula, D. (1984). "Genes for alkaline protease and neutral protease from Bacillus amyloliquefaciens contain a large open reading frame between the regions coding for signal sequence and mature protein". J. Bacteriol. 159: 811–819. PMID 6090391.
  6. ↑ Yang, M.Y., Ferrari, E. and Henner, D.J. (1984). "Cloning of the neutral protease gene of Bacillus subtilis and the use of the cloned gene to create an in vitro-derived deletion mutation". J. Bacteriol. 160: 15–21. PMID 6090407.
  7. ↑ Takagi, M., Imanaka, T. and Aiba, S. (1985). "Nucleotide sequence and promoter region for the neutral protease gene from Bacillus stearothermophilus". J. Bacteriol. 163: 824–831. PMID 2993245.
  8. ↑ Sidler, W., Niederer, E., Suter, F. and Zuber, H. (1986). "The primary structure of Bacillus cereus neutral proteinase and comparison with thermolysin and Bacillus subtilis neutral proteinase". Biol. Chem. Hoppe-Seyler 367: 643–657. doi:10.1515/bchm3.1986.367.2.643. PMID 3092843.
  9. ↑ Pauptit, R.A., Karlson, R., Picot, D., Jenkins, J.A., Niklaus-Reimer, A.-S. and Jansonius, J.N. (1988). "Crystal structure of neutral protease from Bacillus cereus refined at 3.0 Å resolution and comparison with the homologous but more thermostable enzyme thermolysin". J. Mol. Biol. 199: 525–537. doi:10.1016/0022-2836(88)90623-7. PMID 3127592.
  10. ↑ Stoeva, S., Kleinschmidt, T., Mesrob, B. and Braunitzer, G. (1990). "Primary structure of a zinc protease from Bacillus mesentericus strain 76". Biochemistry 29: 527–534. doi:10.1021/bi00454a029. PMID 2302386.

External links

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