Bile-acid 7alpha-dehydratase
In enzymology, a bile-acid 7alpha-dehydratase (EC 4.2.1.106) is an enzyme that catalyzes the chemical reaction
- 7alpha,12alpha-dihydroxy-3-oxochol-4-enoate
12alpha-hydroxy-3-oxochola-4,6-dienoate + H2O
Hence, this enzyme has one substrate, 7alpha,12alpha-dihydroxy-3-oxochol-4-enoate, and two products, 12alpha-hydroxy-3-oxochola-4,6-dienoate and H2O.
This enzyme belongs to the family of lyases, specifically the hydro-lyases, which cleave carbon-oxygen bonds. The systematic name of this enzyme class is 7alpha,12alpha-dihydroxy-3-oxochol-4-enoate hydro-lyase (12alpha-hydroxy-3-oxochola-4,6-dienoate-forming). This enzyme is also called 7alpha,12alpha-dihydroxy-3-oxochol-4-enoate hydro-lyase.
References
- Dawson JA, Mallonee DH, Bjorkhem I, Hylemon PB (1996). "Expression and characterization of a C24 bile acid 7 alpha-dehydratase from Eubacterium sp. strain VPI 12708 in Escherichia coli". J. Lipid. Res. 37 (6): 1258–67. PMID 8808760.
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