Bone morphogenetic protein 3

Bone morphogenetic protein 3
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 2QCQ​
Identifiers
Symbols	BMP3 ; BMP-3A
External IDs	OMIM: 112263 MGI: 88179 HomoloGene: 927 GeneCards: BMP3 Gene
Gene ontology Molecular function • receptor binding • cytokine activity • transforming growth factor beta receptor binding • growth factor activity • BMP receptor binding Cellular component • extracellular space • extracellular exosome Biological process • skeletal system development • osteoblast differentiation • cell-cell signaling • positive regulation of pathway-restricted SMAD protein phosphorylation • growth • regulation of apoptotic process • regulation of MAPK cascade • positive regulation of transcription from RNA polymerase II promoter • cell development • cartilage development • SMAD protein signal transduction Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	651	110075
Ensembl	ENSG00000152785	ENSMUSG00000029335
UniProt	P12645	Q8BHE5
RefSeq (mRNA)	NM_001201	NM_173404
RefSeq (protein)	NP_001192	NP_775580
Location (UCSC)	Chr 4: 81.03 – 81.06 Mb	Chr 5: 98.85 – 98.88 Mb
PubMed search

Bone morphogenetic protein 3 is a protein in humans that is encoded by the BMP3 gene.^[1]

The protein encoded by this gene is a member of the transforming growth factor beta superfamily. It, like other bone morphogenetic proteins (BMP's) is known for its ability to induce bone and cartilage development. It is a disulfide-linked homodimer. It negatively regulates bone density. BMP3 is an antagonist to other BMP's in the differentiation of osteogenic progenitors.

It is highly expressed in fractured tissues.

References

1. "Entrez Gene: BMP3 bone morphogenetic protein 3 (osteogenic)".

Further reading

• Dickinson ME, Kobrin MS, Silan CM, et al. (1990). "Chromosomal localization of seven members of the murine TGF-beta superfamily suggests close linkage to several morphogenetic mutant loci". Genomics 6 (3): 505–20. doi:10.1016/0888-7543(90)90480-I. PMID 1970330.
• Tabas JA, Zasloff M, Wasmuth JJ, et al. (1991). "Bone morphogenetic protein: chromosomal localization of human genes for BMP1, BMP2A, and BMP3". Genomics 9 (2): 283–9. doi:10.1016/0888-7543(91)90254-C. PMID 2004778.
• Paralkar VM, Nandedkar AK, Pointer RH, et al. (1990). "Interaction of osteogenin, a heparin binding bone morphogenetic protein, with type IV collagen". J. Biol. Chem. 265 (28): 17281–4. PMID 2211625.
• Rosen V, Wozney JM, Wang EA, et al. (1990). "Purification and molecular cloning of a novel group of BMPs and localization of BMP mRNA in developing bone". Connect. Tissue Res. 20 (1–4): 313–9. doi:10.3109/03008208909023902. PMID 2612162.
• Wozney JM, Rosen V, Celeste AJ, et al. (1989). "Novel regulators of bone formation: molecular clones and activities". Science 242 (4885): 1528–34. doi:10.1126/science.3201241. PMID 3201241.
• Faucheux C, Ulysse F, Bareille R, et al. (1998). "Opposing actions of BMP3 and TGF beta 1 in human bone marrow stromal cell growth and differentiation". Biochem. Biophys. Res. Commun. 241 (3): 787–93. doi:10.1006/bbrc.1997.7792. PMID 9434787.
• Daluiski A, Engstrand T, Bahamonde ME, et al. (2001). "Bone morphogenetic protein-3 is a negative regulator of bone density". Nat. Genet. 27 (1): 84–8. doi:10.1038/83810. PMID 11138004.
• Jin Y, Lu HB, Liong E, et al. (2002). "Transcriptional mRNA of BMP-2, 3, 4 and 5 in trigeminal nerve, benign and malignant peripheral nerve sheath tumors". Histol. Histopathol. 16 (4): 1013–9. PMID 11642720.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Kloen P, Di Paola M, Borens O, et al. (2004). "BMP signaling components are expressed in human fracture callus". Bone 33 (3): 362–71. doi:10.1016/S8756-3282(03)00191-1. PMID 13678778.
• Kang Q, Sun MH, Cheng H, et al. (2004). "Characterization of the distinct orthotopic bone-forming activity of 14 BMPs using recombinant adenovirus-mediated gene delivery". Gene Ther. 11 (17): 1312–20. doi:10.1038/sj.gt.3302298. PMID 15269709.
• Chen AL, Fang C, Liu C, et al. (2004). "Expression of bone morphogenetic proteins, receptors, and tissue inhibitors in human fetal, adult, and osteoarthritic articular cartilage". J. Orthop. Res. 22 (6): 1188–92. doi:10.1016/j.orthres.2004.02.013. PMID 15475196.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.