GDF7

Growth differentiation factor 7
Identifiers
Symbols	GDF7 ; BMP12
External IDs	OMIM: 604651 MGI: 95690 HomoloGene: 32177 GeneCards: GDF7 Gene
Gene ontology Molecular function • cytokine activity • transforming growth factor beta receptor binding • protein binding • growth factor activity • protein homodimerization activity Cellular component • extracellular space Biological process • axon guidance • positive regulation of pathway-restricted SMAD protein phosphorylation • roof plate formation • spinal cord association neuron differentiation • gland morphogenesis • BMP signaling pathway • epithelial cell differentiation • midbrain development • activin receptor signaling pathway • growth • regulation of apoptotic process • regulation of MAPK cascade • cell fate commitment • positive regulation of neuron differentiation • positive regulation of transcription, DNA-templated • cell development • reproductive structure development • branching morphogenesis of an epithelial tube • forebrain morphogenesis • pathway-restricted SMAD protein phosphorylation • SMAD protein signal transduction • morphogenesis of an epithelial fold • positive regulation of tendon cell differentiation Sources: Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	151449	238057
Ensembl	ENSG00000143869	ENSMUSG00000037660
UniProt	Q7Z4P5	P43029
RefSeq (mRNA)	NM_182828	NM_013527
RefSeq (protein)	NP_878248	NP_038555
Location (UCSC)	Chr 2: 20.67 – 20.68 Mb	Chr 12: 8.3 – 8.3 Mb
PubMed search

Growth differentiation factor 7 (GDF7) is a protein that in humans is encoded by the GDF7 gene.^[1]

GDF7 belongs to the transforming growth factor beta superfamily that is specifically found in a signaling center known as the roof plate that is located in the developing nervous system of embryos. The roof plate is required for the generation of several classes of spinal cord dorsal interneurons; GDF7 specifically induces the formation of sensory neurons in the dorsal spinal cord from neural crest cells by generating signals within the roof plate.^[1][2]

References

1. Lee KJ, Mendelsohn M, Jessell TM (November 1998). "Neuronal patterning by BMPs: a requirement for GDF7 in the generation of a discrete class of commissural interneurons in the mouse spinal cord". Genes Dev. 12 (21): 3394–407. doi:10.1101/gad.12.21.3394. PMC 317230. PMID 9808626.
2. Lo L, Dormand E, Anderson D (2005). "Late-emigrating neural crest cells in the roof plate are restricted to a sensory fate by GDF7". Proc Natl Acad Sci USA 102 (20): 7192–7. doi:10.1073/pnas.0502581102. PMC 1091754. PMID 15883363.

Further reading

• Davila S, Froeling FE, Tan A, et al. (2010). "New genetic associations detected in a host response study to hepatitis B vaccine". Genes Immun. 11 (3): 232–8. doi:10.1038/gene.2010.1. PMID 20237496.
• Davidson AJ, Postlethwait JH, Yan YL, et al. (1999). "Isolation of zebrafish gdf7 and comparative genetic mapping of genes belonging to the growth/differentiation factor 5, 6, 7 subgroup of the TGF-beta superfamily". Genome Res. 9 (2): 121–9. doi:10.1101/gr.9.2.121. PMID 10022976.
• Butler SJ, Dodd J (2003). "A role for BMP heterodimers in roof plate-mediated repulsion of commissural axons". Neuron 38 (3): 389–401. doi:10.1016/S0896-6273(03)00254-X. PMID 12741987.
• Mazerbourg S, Sangkuhl K, Luo CW, et al. (2005). "Identification of receptors and signaling pathways for orphan bone morphogenetic protein/growth differentiation factor ligands based on genomic analyses". J. Biol. Chem. 280 (37): 32122–32. doi:10.1074/jbc.M504629200. PMID 16049014.