Bone morphogenetic protein 8A

Bone morphogenetic protein 8a
Identifiers
Symbols	BMP8A ; FLJ14351; FLJ45264
External IDs	MGI: 104515 HomoloGene: 135983 GeneCards: BMP8A Gene
Gene ontology Molecular function • cytokine activity • transforming growth factor beta receptor binding • growth factor activity • BMP receptor binding Cellular component • extracellular space Biological process • ossification • diet induced thermogenesis • positive regulation of pathway-restricted SMAD protein phosphorylation • BMP signaling pathway • growth • regulation of apoptotic process • regulation of MAPK cascade • negative regulation of insulin secretion • cell development • cartilage development • SMAD protein signal transduction • regulation of energy homeostasis Sources: Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	353500	12163
Ensembl	ENSG00000183682	ENSMUSG00000032726
UniProt	Q7Z5Y6	P34821
RefSeq (mRNA)	NM_181809	NM_001256019
RefSeq (protein)	NP_861525	NP_001242948
Location (UCSC)	Chr 1: 39.49 – 39.53 Mb	Chr 4: 123.31 – 123.34 Mb
PubMed search

Bone morphogenetic protein 8A (BMP8A) is a protein that in humans is encoded by the BMP8A gene.^[1]

BMP8A is a polypeptide member of the TGFβ superfamily of proteins. It, like other bone morphogenetic proteins (BMPs), is involved in the development of bone and cartilage. BMP8A may be involved in epithelial osteogenesis. It also plays a role in bone homeostasis. It is a disulfide-linked homodimer.

References

1. "Entrez Gene: bone morphogenetic protein 8a".

Further reading

• Davila S, Froeling FE, Tan A; et al. (2010). "New genetic associations detected in a host response study to hepatitis B vaccine.". Genes Immun. 11 (3): 232–8. doi:10.1038/gene.2010.1. PMID 20237496.
• Strausberg RL, Feingold EA, Grouse LH; et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Gregory SG, Barlow KF, McLay KE; et al. (2006). "The DNA sequence and biological annotation of human chromosome 1.". Nature 441 (7091): 315–21. doi:10.1038/nature04727. PMID 16710414.
• Ota T, Suzuki Y, Nishikawa T; et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.