Calpain-3

Calpain-3 (EC 3.4.22.54, p94, calpain p94, CAPN3, muscle calpain, calpain 3, calcium-activated neutral proteinase 3, muscle-specific calcium-activated neutral protease 3, CANP 3, calpain L3) is an enzyme.^[1]^[2]^[3]^[4]^[5] This enzyme catalyses the following chemical reaction

Broad endopeptidase activity

This Ca²⁺ dependent enzyme is found in skeletal muscles.

References

↑ Sorimachi, H., Imajoh-Ohmi, S., Emori, Y., Kawasaki, H., Ohno, S., Minami, Y. and Suzuki, K. (1989). "Molecular cloning of a novel mammalian calcium-dependent protease distinct from both m- and μ-types. Specific expression of the mRNA in skeletal muscle". J. Biol. Chem. 264 (33): 20106–20111. PMID 2555341.
↑ Sorimachi, H., Kinbara, K., Kimura, S., Takahashi, M., Ishiura, S., Sasagawa, N., Sorimachi, N., Shimada, H., Tagawa, K., Maruyama, K. and Suzuki, K. (1995). "Muscle-specific calpain, p94, responsible for limb girdle muscular dystrophy type 2A, associates with connectin through IS2, a p94-specific sequence". J. Biol. Chem. 270: 31158–31162. doi:10.1074/jbc.270.52.31158. PMID 8537379.
↑ Rey, M.A. and Davies, P.L. (2002). "The protease core of the muscle-specific calpain, p94, undergoes Ca²⁺-dependent intramolecular autolysis". FEBS Lett. 532 (3): 401–406. doi:10.1016/s0014-5793(02)03722-5. PMID 12482600.
↑ García Díaz, B.E., Gauthier, S. and Davies, P.L. (2006). "Ca²⁺ dependency of calpain 3 (p94) activation". Biochemistry 45 (11): 3714–3722. doi:10.1021/bi051917j. PMID 16533054.
↑ Ono, Y., Torii, F., Ojima, K., Doi, N., Yoshioka, K., Kawabata, Y., Labeit, D., Labeit, S., Suzuki, K., Abe, K., Maeda, T. and Sorimachi, H. (2006). "Suppressed disassembly of autolyzing p94/CAPN3 by N2A connectin/titin in a genetic reporter system". J. Biol. Chem. 281 (27): 18519–18531. doi:10.1074/jbc.M601029200. PMID 16627476.

External links

Calpain-3 at the US National Library of Medicine Medical Subject Headings (MeSH)

Proteases: cysteine proteases (EC 3.4.22)

Caspase	Caspase 1 Caspase 2 Caspase 3 Caspase 4 Caspase 5 Caspase 6 Caspase 7 Caspase 8 Caspase 9 Caspase 10 Caspase 12 Caspase 13 Caspase 14

Fruit-derived	Papain Ficain Bromelain Actinidain

Calpain	CAPN1 CAPN2 CAPN3 CAPN5 CAPN6 CAPN7 CAPN8 CAPN9 CAPN10 CAPN11 CAPN12 CAPN13 CAPN14 CAPNS1 CAPNS2

Cathepsin	B C F H K L1/L2 O S W Z

Other	Clostripain Cancer procoagulant Separase Autophagin Cruzipain

Proteins: enzymes

Activity	Active site Binding site Catalytic triad Oxyanion hole Enzyme promiscuity Catalytically perfect enzyme Coenzyme Cofactor Enzyme catalysis Enzyme kinetics Lineweaver–Burk plot Michaelis–Menten kinetics

Regulation	Allosteric regulation Cooperativity Enzyme inhibitor

Classification	EC number Enzyme superfamily Enzyme family List of enzymes

Types	EC1 Oxidoreductases(list) EC2 Transferases(list) EC3 Hydrolases(list) EC4 Lyases(list) EC5 Isomerases(list) EC6 Ligases(list)

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Calpain-3

See also

References

External links