Cefminox

Cefminox

Systematic (IUPAC) name
(6R,7S)-7-(((((2S)-2-amino-2-carboxyethyl)thio)acetyl)amino)-7-methoxy-3-(((1-methyl-1H-tetrazol-5-yl)thio)methyl)-8-oxo-5-thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylic acid
Clinical data
AHFS/Drugs.com	International Drug Names
Routes of administration	IM, IV
Legal status	℞ (Prescription only)
Identifiers
CAS Number	84305-41-9
ATC code	J01DC12 (WHO)
PubChem	CID 71141
ChemSpider	64286
UNII	PW08Y13465
KEGG	D07642
ChEMBL	CHEMBL1276342
Chemical data
Formula	C16H21N7O7S3
Molar mass	519.57 g/mol
SMILES O=C2N1/C(=C(\CS[C@@H]1[C@]2(OC)NC(=O)CSC[C@H](C(=O)O)N)CSc3nnnn3C)C(=O)O
InChI InChI=1S/C16H21N7O7S3/c1-22-15(19-20-21-22)33-4-7-3-32-14-16(30-2,13(29)23(14)10(7)12(27)28)18-9(24)6-31-5-8(17)11(25)26/h8,14H,3-6,17H2,1-2H3,(H,18,24)(H,25,26)(H,27,28)/t8-,14-,16+/m1/s1 Key:JSDXOWVAHXDYCU-VXSYNFHWSA-N
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Cefminox (INN) is a second-generation cephalosporin antibiotic.^[1][2]

Spectrum

Cefminox is a broad-spectrum, bactericidal cephalosporin antibiotic. It is especially effective against Gram-negative and anaerobic bacteria. The following represents MIC data for a few medically significant microorganisms.

• Clostridium difficile: 2 - 4 µg/ml
• Escherichia coli: 0.125 - 16 µg/ml
• Pseudomonas aeruginosa: 256 µg/ml

^[3]

References

1. Torres, A. J.; Valladares, L. D.; Jover, J. M.; Sánchez-Pernaute, A.; Frías, J.; Carcas, A. J.; Coronel, P.; Ródenas, E.; Pérez-Balcabao, I.; Fernández-Roblas, R.; Moreno, M.; Balibrea, J. L. (2000). "Cefminox versus metronidazole plus gentamicin intra-abdominal infections: A prospective randomized controlled clinical trial". Infection 28 (5): 318–322. doi:10.1007/s150100070027. PMID 11073141.
2. Patentdocs: Reaction Medium For Methicillin-Resistant Staphylococcus Aureus (Mrsa) Bacteria
3. http://www.toku-e.com/Assets/MIC/Cefminox%20sodium.pdf