Chebulagic acid
Identifiers | |
---|---|
23094-71-5 | |
ChEMBL | ChEMBL525240 |
Jmol interactive 3D | Image |
PubChem | 12400 |
| |
| |
Properties | |
C41H30O27 | |
Molar mass | 954.66 g/mol |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). | |
verify (what is ?) | |
Infobox references | |
Chebulagic acid is a benzopyran tannin and an antioxidant that has many potential uses in medicine.
It has been found to be immunosuppressive,[1] hepatoprotective,[2] and a potent alpha-glucosidase inhibitor,[3][4] a human gut enzyme useful in diabetic studies.
It has been shown to be active against Staphylococcus aureus and Candida albicans[5]
It is found in the plants Terminalia chebula, T. citrina and T. catappa.[6]
It is formed from geraniin through a glutathione-mediated conversion.[7]
References
- ↑ HAMADA, Shin-ichi; KATAOKA, Takao; WOO, Je-Tae; YAMADA, Atsushi; YOSHIDA, Takashi; NISHIMURA, Toshio; OTAKE, Noboru; NAGAI, Kazuo (1997). "Immunosuppressive Effects of Gallic Acid and Chebulagic Acid on CTL-Mediated Cytotoxicity.". Biological & Pharmaceutical Bulletin 20 (9): 1017–1019. doi:10.1248/bpb.20.1017.
- ↑ Kinoshita, S.; Inoue, Y.; Nakama, S.; Ichiba, T.; Aniya, Y. (November 2007). "Antioxidant and hepatoprotective actions of medicinal herb, Terminalia catappa L. from Okinawa Island and its tannin corilagin". Phytomedicine 14 (11): 755–762. doi:10.1016/j.phymed.2006.12.012.
- ↑ Sasidharan, J Enzyme Inhib Med Chem 27:578 2012 PMID 22512724
- ↑ Pham, Pharm Biol 2014 PMID 24635511
- ↑
- ↑ Chemopreventive effect of punicalagin, a novel tannin component isolated from Terminalia catappa, on H-ras-transformed NIH3T3 cells. Pin-Shern Chen and Jih-Heng Li, Toxicology Letters, Volume 163, Issue 1, 5 May 2006, Pages 44-53
- ↑ Glutathione-mediated conversion of the ellagitannin geraniin into chebulagic acid. Tanaka T, Kouno I and Nonaka G.I, Chemical and pharmaceutical bulletin, 1996, volume 44, no 1, pages 34-40, INIST:3003361
|
This article is issued from Wikipedia - version of the Friday, February 12, 2016. The text is available under the Creative Commons Attribution/Share Alike but additional terms may apply for the media files.