Diclofenamide

Diclofenamide

Systematic (IUPAC) name
4,5-Dichlorobenzene-1,3-disulfonamide
Clinical data
AHFS/Drugs.com	International Drug Names
MedlinePlus	a601233
Pharmacokinetic data
Protein binding	55%
Identifiers
CAS Number	120-97-8
ATC code	S01EC02 (WHO)
PubChem	CID 3038
IUPHAR/BPS	6807
DrugBank	DB01144
ChemSpider	2930
UNII	VVJ6673MHY
KEGG	D00518
ChEBI	CHEBI:101085
ChEMBL	CHEMBL17
Chemical data
Formula	C6H6Cl2N2O4S2
Molar mass	305.16 g/mol
SMILES Clc1c(cc(cc1Cl)S(=O)(=O)N)S(=O)(=O)N
InChI InChI=1S/C6H6Cl2N2O4S2/c7-4-1-3(15(9,11)12)2-5(6(4)8)16(10,13)14/h1-2H,(H2,9,11,12)(H2,10,13,14) Key:GJQPMPFPNINLKP-UHFFFAOYSA-N
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Diclofenamide (or dichlorphenamide) is a sulfonamide and a carbonic anhydrase inhibitor of the meta-disulfamoylbenzene class.

Uses

Diclofenamide is used to treat glaucoma^[1][2] and therapy-resistant epilepsy.^[3]

References

1. International Drug Names: Diclofenamide
2. Kanski, J. J. (1968). "Carbonic anhydrase inhibitors and osmotic agents in glaucoma. Carbonic anhydrase inhibitors". The British journal of ophthalmology 52 (8): 642–643. doi:10.1136/bjo.52.8.642. PMC 506660. PMID 5724852.
3. Rucquoy, M.; Sorel, L. (1978). "Diclofenamide in the treatment of therapy-resistant epilepsy". Acta neurologica Belgica 78 (3): 174–182. PMID 352085.