Ent-isokaurene synthase

Ent-isokaurene synthase
Identifiers
EC number	4.2.3.103
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Search PMC articles PubMed articles NCBI proteins

Ent-isokaurene synthase (EC 4.2.3.103, OsKSL5i, OsKSL6) is an enzyme with systematic name ent-copalyl-diphosphate diphosphate-lyase (cyclizing, ent-isokaurene-forming).^[1][2] This enzyme catalyses the following chemical reaction

ent-copalyl diphosphate $\rightleftharpoons$ ent-isokaurene + diphosphate

Two enzymes of the rice sub-species Oryza sativa ssp. indica, OsKSL5 and OsKSL6, produce ent-isokaurene.

References

1. Xu, M., Wilderman, P.R., Morrone, D., Xu, J., Roy, A., Margis-Pinheiro, M., Upadhyaya, N.M., Coates, R.M. and Peters, R.J. (2007). "Functional characterization of the rice kaurene synthase-like gene family". Phytochemistry 68: 312–326. doi:10.1016/j.phytochem.2006.10.016. PMID 17141283.
2. Xu, M., Wilderman, P.R. and Peters, R.J. (2007). "Following evolution’s lead to a single residue switch for diterpene synthase product outcome". Proc. Natl. Acad. Sci. USA 104: 7397–7401. doi:10.1073/pnas.0611454104. PMID 17456599.

External links

• Ent-isokaurene synthase at the US National Library of Medicine Medical Subject Headings (MeSH)