Estrone sulfate

Estrone sulfate

Names
IUPAC name [(8R,9S,13S,14S)-13-methyl-17-oxo-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthren-3-yl] hydrogen sulfate
Identifiers
CAS Number	438-67-5
ChEBI	CHEBI:17474
ChEMBL	ChEMBL494753
ChemSpider	2272513
DrugBank	DB04574
IUPHAR/BPS	4749
Jmol interactive 3D	Image
PubChem	3001028
UNII	6K6FDA543A
InChI InChI=1S/C18H22O5S/c1-18-9-8-14-13-5-3-12(23-24(20,21)22)10-11(13)2-4-15(14)16(18)6-7-17(18)19/h3,5,10,14-16H,2,4,6-9H2,1H3,(H,20,21,22)/t14-,15-,16+,18+/m1/s1 Key: JKKFKPJIXZFSSB-CBZIJGRNSA-N InChI=1/C18H22O5S/c1-18-9-8-14-13-5-3-12(23-24(20,21)22)10-11(13)2-4-15(14)16(18)6-7-17(18)19/h3,5,10,14-16H,2,4,6-9H2,1H3,(H,20,21,22)/t14-,15-,16+,18+/m1/s1 Key: JKKFKPJIXZFSSB-CBZIJGRNBR
SMILES O=S(=O)(O)Oc1cc4c(cc1)[C@H]3CC[C@@]2(C(=O)CC[C@H]2[C@@H]3CC4)C
Properties
Chemical formula	C18H22O5S
Molar mass	350.43 g/mol
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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Infobox references

Estrone sulfate is a sulfated estrone ester and estrogen found in the conjugated estrogen formulation Premarin.^[1]

It has been described as a prognosis indicator for prostate cancer.^[2]

See also

• Conjugated estrogen
• Esterified estrogen
• Estrogen ester
• Estrone sulfotransferase
• Estropipate

References

1. Horne C, Chew BP, Wiseman BS, Dziuk PJ (August 1983). "Relationship between the level of estrone sulfate in the plasma and the number of fetuses during pregnancy in the gilt". Biol. Reprod. 29 (1): 56–62. doi:10.1095/biolreprod29.1.56. PMID 6615969.
2. Giton F, de la Taille A, Allory Y; et al. (March 2008). "Estrone sulfate (E1S), a prognosis marker for tumor aggressiveness in prostate cancer (PCa)". J. Steroid Biochem. Mol. Biol. 109 (1–2): 158–67. doi:10.1016/j.jsbmb.2007.10.005. PMID 18337090.