FUT7

Fucosyltransferase 7 (alpha (1,3) fucosyltransferase)
Identifiers
Symbols	FUT7 ; FucT-VII
External IDs	OMIM: 602030 MGI: 107692 HomoloGene: 3296 GeneCards: FUT7 Gene
EC number	2.4.1.-
Gene ontology Molecular function • fucosyltransferase activity • transferase activity, transferring glycosyl groups • alpha-(1->3)-fucosyltransferase activity Cellular component • Golgi apparatus • membrane • integral to membrane • Golgi cisterna membrane Biological process • CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation • leukocyte migration involved in immune response • protein glycosylation • fucosylation • L-fucose catabolic process Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	2529	14347
Ensembl	ENSG00000180549	ENSMUSG00000036587
UniProt	Q11130	Q11131
RefSeq (mRNA)	NM_004479.3	NM_001177366.1
RefSeq (protein)	NP_004470.1	NP_001170837.1
Location (UCSC)	Chr 9: 139.92 – 139.93 Mb	Chr 2: 25.28 – 25.28 Mb
PubMed search

Alpha-(1,3)-fucosyltransferase is an enzyme that in humans is encoded by the FUT7 gene.^[1][2][3]

The sialyl Lewis x oligosaccharide determinant is an essential component of leukocyte counterreceptors for E-selectin- (MIM 131210) and P-selectin- (MIM 173610) mediated adhesions of leukocytes. This oligosaccharide molecule is displayed on the surfaces of granulocytes, monocytes, and natural killer cells. Formation of leukocyte adhesions to these selectins is an early and important step in the process that ultimately allows leukocytes to leave the vascular tree and become recruited into lymphoid tissues and sites of inflammation.[supplied by OMIM]^[3]

References

1. Natsuka S, Gersten KM, Zenita K, Kannagi R, Lowe JB (Jul 1994). "Molecular cloning of a cDNA encoding a novel human leukocyte alpha-1,3-fucosyltransferase capable of synthesizing the sialyl Lewis x determinant". J Biol Chem 269 (24): 16789–94. PMID 8207002.
2. Sasaki K, Kurata K, Funayama K, Nagata M, Watanabe E, Ohta S, Hanai N, Nishi T (Jun 1994). "Expression cloning of a novel alpha 1,3-fucosyltransferase that is involved in biosynthesis of the sialyl Lewis x carbohydrate determinants in leukocytes". J Biol Chem 269 (20): 14730–7. PMID 8182079.
3. "Entrez Gene: FUT7 fucosyltransferase 7 (alpha (1,3) fucosyltransferase)".

Further reading

• Natsuka S, Gersten KM, Zenita K, et al. (1994). "Molecular cloning of a cDNA encoding a novel human leukocyte alpha-1,3-fucosyltransferase capable of synthesizing the sialyl Lewis x determinant". J. Biol. Chem. 269 (32): 20806. PMID 8051184.
• Smith PL, Gersten KM, Petryniak B, et al. (1996). "Expression of the alpha(1,3)fucosyltransferase Fuc-TVII in lymphoid aggregate high endothelial venules correlates with expression of L-selectin ligands". J. Biol. Chem. 271 (14): 8250–9. doi:10.1074/jbc.271.14.8250. PMID 8626519.
• Le Marer N, Palcic MM, Clarke JL, et al. (1997). "Developmental regulation of alpha 1,3-fucosyltransferase expression in CD34 positive progenitors and maturing myeloid cells isolated from normal human bone marrow". Glycobiology 7 (3): 357–65. doi:10.1093/glycob/7.3.357. PMID 9147044.
• Mas E, Pasqualini E, Caillol N, et al. (1998). "Fucosyltransferase activities in human pancreatic tissue: comparative study between cancer tissues and established tumoral cell lines". Glycobiology 8 (6): 605–13. doi:10.1093/glycob/8.6.605. PMID 9592127.
• Bengtson P, Larson C, Lundblad A, et al. (2001). "Identification of a missense mutation (G329A;Arg(110)--> GLN) in the human FUT7 gene". J. Biol. Chem. 276 (34): 31575–82. doi:10.1074/jbc.M104165200. PMID 11404359.
• de Vries T, Yen TY, Joshi RK, et al. (2001). "Neighboring cysteine residues in human fucosyltransferase VII are engaged in disulfide bridges, forming small loop structures". Glycobiology 11 (5): 423–32. doi:10.1093/glycob/11.5.423. PMID 11425803.
• Roos C, Kolmer M, Mattila P, Renkonen R (2002). "Composition of Drosophila melanogaster proteome involved in fucosylated glycan metabolism". J. Biol. Chem. 277 (5): 3168–75. doi:10.1074/jbc.M107927200. PMID 11698403.
• Zerfaoui M, Fukuda M, Langlet C, et al. (2002). "The cytosolic and transmembrane domains of the beta 1,6 N-acetylglucosaminyltransferase (C2GnT) function as a cis to medial/Golgi-targeting determinant". Glycobiology 12 (1): 15–24. doi:10.1093/glycob/12.1.15. PMID 11825883.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Hiraiwa N, Yabuta T, Yoritomi K, et al. (2003). "Transactivation of the fucosyltransferase VII gene by human T-cell leukemia virus type 1 Tax through a variant cAMP-responsive element". Blood 101 (9): 3615–21. doi:10.1182/blood-2002-07-2301. PMID 12506041.
• Humphray SJ, Oliver K, Hunt AR, et al. (2004). "DNA sequence and analysis of human chromosome 9". Nature 429 (6990): 369–74. doi:10.1038/nature02465. PMC 2734081. PMID 15164053.
• Zisoulis DG, Kansas GS (2004). "H-Ras and phosphoinositide 3-kinase cooperate to induce alpha(1,3)-fucosyltransferase VII expression in Jurkat T cells". J. Biol. Chem. 279 (38): 39495–504. doi:10.1074/jbc.M407904200. PMID 15262995.
• Miyashiro M, Furuya S, Fujishige K, Sugita T (2004). "Highly sensitive cell-based assay system to monitor the sialyl Lewis X biosynthesis mediated by alpha1-3 fucosyltransferase-VII". Biochem. Biophys. Res. Commun. 324 (1): 98–107. doi:10.1016/j.bbrc.2004.09.025. PMID 15464988.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Martinez M, Joffraud M, Giraud S, et al. (2005). "Regulation of PSGL-1 interactions with L-selectin, P-selectin, and E-selectin: role of human fucosyltransferase-IV and -VII". J. Biol. Chem. 280 (7): 5378–90. doi:10.1074/jbc.M410899200. PMID 15579466.
• Prorok-Hamon M, Notel F, Mathieu S, et al. (2006). "N-glycans of core2 β(1,6)-N-acetylglucosaminyltransferase-I (C2GnT-I) but not those of α(1,3)-fucosyltransferase-VII (FucT-VII) are required for the synthesis of functional P-selectin glycoprotein ligand-1 (PSGL-1): effects on P-, L- and E-selectin binding". Biochem. J. 391 (Pt 3): 491–502. doi:10.1042/BJ20050344. PMC 1276950. PMID 15926890.
• Brown V, Brown RA, Ozinsky A, et al. (2006). "Binding specificity of Toll-like receptor cytoplasmic domains". Eur. J. Immunol. 36 (3): 742–53. doi:10.1002/eji.200535158. PMC 2762736. PMID 16482509.
• Wang QY, Zhang Y, Chen HJ, et al. (2007). "Alpha 1,3-fucosyltransferase-VII regulates the signaling molecules of the insulin receptor pathway". FEBS J. 274 (2): 526–38. doi:10.1111/j.1742-4658.2006.05599.x. PMID 17229154.