Fibrolase

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Fibrolase (EC 3.4.24.72, fibrinolytic proteinase, Agkistrodon contortrix contortrix metalloproteinase, Agkistrodon contortrix contortrix venom metalloproteinase) is an enzyme.^[1]^[2]^[3]^[4]^[5] This enzyme catalyses the following chemical reaction

Hydrolysis of -Ala¹⁴-Leu- in insulin B chain and -Lys⁴¹³-Leu- in Aalpha-chain of fibrinogen

This enzyme is present in the venom of the southern copperhead snake (Agkistrodon contortrix contortrix).

References

↑ Retzios, A.D. and Markland, F.S., Jr. (1988). "A direct-acting fibrinolytic enzyme from the venom of Agkistrodon contortrix contortrix: effects on various components of the human blood coagulation and fibrinolysis systems". Thromb. Res. 52: 541–552. doi:10.1016/0049-3848(88)90127-2. PMID 3232124.
↑ Guan, A.L., Retzios, A.D., Henderson, G.N. and Markland, F.S., Jr. (1991). "Purification and characterization of a fibrinolytic enzyme from venom of southern copperhead snake (Agkistrodon contortrix contortrix)". Arch. Biochem. Biophys. 289: 197–207. doi:10.1016/0003-9861(91)90462-r. PMID 1898066.
↑ Randolph, A., Chamberlain, S.H., Chu, H.L.C., Retzios, A.D., Markland, F.S. (1992). "Jr. and Masiarz, F.R. Amino acid sequence of fibrolase, a direct-acting fibrinolytic enzyme from Agkistrodon contortrix venom". Protein Sci. 1: 590–600. doi:10.1002/pro.5560010505. PMID 1304358.
↑ Loayza, S.L., Trikha, M., Markland, F.S., Riquelme, P. and Kuo, J. (1994). "Resolution of isoforms of natural and recombinant fibrolase, the fibrinolytic enzyme from Agkistrodon contortrix contortrix snake venom, and comparison of their EDTA sensitivities". J. Chromatogr. B Biomed. Appl. 662: 227–243. doi:10.1016/0378-4347(94)00202-9. PMID 7719479.
↑ Retzios, A.D. and Markland, F.S. (1994). "Fibrinolytic enzymes from the venoms of Agkistrodon contortrix contortrix and Crotalus basilicus basilicus: cleavage site specificity towards the α-chain of fibrin". Thromb. Res. 74: 355–367. doi:10.1016/0049-3848(94)90151-1. PMID 8085237.

External links

Fibrolase at the US National Library of Medicine Medical Subject Headings (MeSH)

Proteases: metalloendopeptidases (EC 3.4.24)

ADAM proteins	Alpha secretases ADAM9 ADAM10 ADAM17 ADAM19 ADAM2 ADAM7 ADAM8 ADAM11 ADAM12 ADAM15 ADAM18 ADAM22 ADAM23 ADAM28 ADAM33 ADAMTS1 ADAMTS2 ADAMTS3 ADAMTS4 ADAMTS5 ADAMTS8 ADAMTS9 ADAMTS10 ADAMTS12 ADAMTS13

Matrix metalloproteinases	Collagenases MMP1 MMP8 Gelatinases MMP2 MMP9 MMP3 MMP7 MMP10 MMP11 MMP12 MMP13 MMP14 MMP15 MMP16 MMP17 MMP19 MMP20 MMP21 MMP23A MMP23B MMP24 MMP25 MMP26 MMP27 MMP28

Other	Neprilysin Procollagen peptidase Thermolysin Pregnancy-associated plasma protein A Bone morphogenetic protein 1 Lysostaphin Insulin-degrading enzyme ZMPSTE24

Proteins: enzymes

Activity	Active site Binding site Catalytic triad Oxyanion hole Enzyme promiscuity Catalytically perfect enzyme Coenzyme Cofactor Enzyme catalysis Enzyme kinetics Lineweaver–Burk plot Michaelis–Menten kinetics

Regulation	Allosteric regulation Cooperativity Enzyme inhibitor

Classification	EC number Enzyme superfamily Enzyme family List of enzymes

Types	EC1 Oxidoreductases(list) EC2 Transferases(list) EC3 Hydrolases(list) EC4 Lyases(list) EC5 Isomerases(list) EC6 Ligases(list)

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