GFRα

The GDNF family receptor-α (GFRα) proteins are a group of co-receptors which form complexes with GDNF-family ligands (GFLs) to activate RET, the receptor of the GFLs. The GFRα co-receptors include the following:

GFRα1 – preference for GDNF
GFRα2 – preference for neurturin
GFRα3 – preference for artemin
GFRα4 – preference for persephin

References

Neurotrophinergics

CNTF

Agonists: Axokine
CNTF

LNGF

Agonists: BDNF
NGF
NT-3
NT-4

Antagonists: SAR127963

RET

GFRα1	Agonists: GDNF

GFRα2	Agonists: Neurturin (NRTN)

GFRα3	Agonists: Artemin (ARTN)

GFRα4	Agonists: Persephin (PSPN)

Trk

TrkA	Agonists: Amitriptyline Gambogic amide NGF Tavilermide Antagonists: FX007

TrkB	Agonists: 3,7-DHF 3,7,8,2'-THF 4'-DMA-7,8-DHF 7,3'-DHF 7,8-DHF 7,8,2'-THF 7,8,3'-THF Amitriptyline BDNF Deoxygedunin Diosmetin HIOC LM22A-4 N-Acetylserotonin NT-3 NT-4 Norwogonin (5,7,8-THF) R7 TDP6 Antagonists: ANA-12 Cyclotraxin B Gossypetin (3,5,7,8,3',4'-HHF) Inhibitors: K252a

TrkC	Agonists: NT-3

Others

Antibodies: Tanezumab (against NGF)

Others: Cerebrolysin (neurotrophin mixture)

Cell signaling: nervous tissue: neurotrophin

Trk binding	NGF BDNF NT-3 NT-4

GFL	GDNF Neurturin Artemin Persephin

Other	CNTF GMF IGF-1 Neuregulin (1, 2, 3, 4) PACAP VEGF

This article is issued from Wikipedia - version of the Thursday, August 07, 2014. The text is available under the Creative Commons Attribution/Share Alike but additional terms may apply for the media files.