GFRA3

GDNF family receptor alpha 3
PDB rendering based on 2gh0.
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 2GH0​
Identifiers
Symbols	GFRA3 ; GDNFR3
External IDs	OMIM: 605710 MGI: 1201403 HomoloGene: 1146 GeneCards: GFRA3 Gene
Gene ontology Molecular function • receptor binding • axon guidance receptor activity Cellular component • cytoplasm • plasma membrane • external side of plasma membrane • extrinsic component of membrane • anchored component of membrane • intracellular membrane-bounded organelle Biological process • neuron migration • signal transduction • nervous system development • axon guidance • peripheral nervous system development • sympathetic nervous system development Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	2676	14587
Ensembl	ENSG00000146013	ENSMUSG00000024366
UniProt	O60609	O35118
RefSeq (mRNA)	NM_001496	NM_010280
RefSeq (protein)	NP_001487	NP_034410
Location (UCSC)	Chr 5: 138.25 – 138.27 Mb	Chr 18: 34.69 – 34.72 Mb
PubMed search

GDNF family receptor alpha-3 (GFRα3), also known as the artemin receptor, is a protein that in humans is encoded by the GFRA3 gene.^[1][2]

Function

The protein encoded by this gene is a glycosylphosphatidylinositol(GPI)-linked cell surface receptor and a member of the GDNF receptor family. It forms a signaling receptor complex with RET tyrosine kinase receptor and binds the ligand, artemin.^[2]

See also

• GFRα

References

1. Jing S, Yu Y, Fang M, Hu Z, Holst PL, Boone T, Delaney J, Schultz H, Zhou R, Fox GM (Dec 1997). "GFRalpha-2 and GFRalpha-3 are two new receptors for ligands of the GDNF family". The Journal of Biological Chemistry 272 (52): 33111–7. doi:10.1074/jbc.272.52.33111. PMID 9407096.
2. "Entrez Gene: GFRA3 GDNF family receptor alpha 3".

Further reading

• Wang X, Baloh RH, Milbrandt J, Garcia KC (Jun 2006). "Structure of artemin complexed with its receptor GFRalpha3: convergent recognition of glial cell line-derived neurotrophic factors". Structure (London, England : 1993) 14 (6): 1083–92. doi:10.1016/j.str.2006.05.010. PMID 16765900.
• Zhang Z, Henzel WJ (Oct 2004). "Signal peptide prediction based on analysis of experimentally verified cleavage sites". Protein Science : A Publication of the Protein Society 13 (10): 2819–24. doi:10.1110/ps.04682504. PMC 2286551. PMID 15340161. Check date values in: |year= / |date= mismatch (help)
• Gimm O, Dziema H, Brown J, Hoang-Vu C, Hinze R, Dralle H, Mulligan LM, Eng C (Apr 2001). "Over-representation of a germline variant in the gene encoding RET co-receptor GFRalpha-1 but not GFRalpha-2 or GFRalpha-3 in cases with sporadic medullary thyroid carcinoma". Oncogene 20 (17): 2161–70. doi:10.1038/sj.onc.1204289. PMID 11360200.
• Onochie CI, Korngut LM, Vanhorne JB, Myers SM, Michaud D, Mulligan LM (Sep 2000). "Characterisation of the human GFRalpha-3 locus and investigation of the gene in Hirschsprung disease". Journal of Medical Genetics 37 (9): 674–9. doi:10.1136/jmg.37.9.674. PMC 1734691. PMID 10978357.
• Baloh RH, Tansey MG, Lampe PA, Fahrner TJ, Enomoto H, Simburger KS, Leitner ML, Araki T, Johnson EM, Milbrandt J (Dec 1998). "Artemin, a novel member of the GDNF ligand family, supports peripheral and central neurons and signals through the GFRalpha3-RET receptor complex". Neuron 21 (6): 1291–302. doi:10.1016/S0896-6273(00)80649-2. PMID 9883723. Check date values in: |year= / |date= mismatch (help)
• Baloh RH, Gorodinsky A, Golden JP, Tansey MG, Keck CL, Popescu NC, Johnson EM, Milbrandt J (May 1998). "GFRalpha3 is an orphan member of the GDNF/neurturin/persephin receptor family". Proceedings of the National Academy of Sciences of the United States of America 95 (10): 5801–6. doi:10.1073/pnas.95.10.5801. PMC 20460. PMID 9576965.
• Masure S, Cik M, Pangalos MN, Bonaventure P, Verhasselt P, Lesage AS, Leysen JE, Gordon RD (Feb 1998). "Molecular cloning, expression and tissue distribution of glial-cell-line-derived neurotrophic factor family receptor alpha-3 (GFRalpha-3)". European Journal of Biochemistry / FEBS 251 (3): 622–30. doi:10.1046/j.1432-1327.1998.2510622.x. PMID 9490034.
• Robertson NG, Khetarpal U, Gutiérrez-Espeleta GA, Bieber FR, Morton CC (Sep 1994). "Isolation of novel and known genes from a human fetal cochlear cDNA library using subtractive hybridization and differential screening". Genomics 23 (1): 42–50. doi:10.1006/geno.1994.1457. PMID 7829101. Check date values in: |year= / |date= mismatch (help)