GW0742

GW0742

Systematic (IUPAC) name
[4-[[[2-[3-fluoro-4-(trifluoromethyl)phenyl]-4-methyl-5-thiazolyl]methyl]thio]-2-methyl phenoxy]-acetic acid[1]
Clinical data
Pregnancy category	N/A
Legal status	Investigational
Identifiers
CAS Number	317318-84-6
ATC code	None
PubChem	CID 9934458
IUPHAR/BPS	2686
ChemSpider	8110086
ChEBI	CHEBI:156132
ChEMBL	CHEMBL38508
Chemical data
Formula	C21H17F4NO3S2
Molar mass	471.488 g/mol
SMILES FC(F)(F)c3c(F)cc(c1nc(c(s1)CSc2cc(c(OCC(=O)O)cc2)C)C)cc3
InChI InChI=InChI=1S/C21H17F4NO3S2/c1-11-7-14(4-6-17(11)29-9-19(27)28)30-10-18-12(2)26-20(31-18)13-3-5-15(16(22)8-13)21(23,24)25/h3-8H,9-10H2,1-2H3,(H,27,28) Key:HWVNEWGKWRGSRK-UHFFFAOYSA-N

GW0742 (also known as GW610742) is a PPARδ/β agonist^[2][3][4] that is investigated for drug use by GlaxoSmithKline.

See also

• GW 501516
• GFT505
• Peroxisome proliferator-activated receptor

References

1. "Cayman Chemical GW0742". Retrieved 31 Mar 2013.
2. Smith, S. A.; Monteith, G. R.; Robinson, J. A.; Venkata, N. G.; May, F. J.; Roberts-Thomson, S. J. (2004). "Effect of the peroxisome proliferator-activated receptor ? Activator GW0742 in rat cultured cerebellar granule neurons". Journal of Neuroscience Research 77 (2): 240–249. doi:10.1002/jnr.20153. PMID 15211590.
3. Haskova, Z.; Hoang, B.; Luo, G.; Morgan, L. A.; Billin, A. N.; Barone, F. C.; Shearer, B. G.; Barton, M. E.; Kilgore, K. S. (2008). "Modulation of LPS-induced pulmonary neutrophil infiltration and cytokine production by the selective PPARβ/δ ligand GW0742". Inflammation Research 57 (7): 314–321. doi:10.1007/s00011-007-7157-4. PMID 18622687.
4. Sznaidman, M. L.; Haffner, C. D.; Maloney, P. R.; Fivush, A.; Chao, E.; Goreham, D.; Sierra, M. L.; Legrumelec, C.; Xu, H. E.; Montana, V. G.; Lambert, M. H.; Willson, T. M.; Oliver, W. R.; Sternbach, D. D. (2003). "Novel selective small molecule agonists for peroxisome proliferator-activated receptor δ (PPARδ)—synthesis and biological activity". Bioorganic & Medicinal Chemistry Letters 13 (9): 1517. doi:10.1016/S0960-894X(03)00207-5.