Gamma-terpinene synthase

Gamma-terpinene synthase (EC 4.2.3.114, OvTPS2, ClcTS) is an enzyme with systematic name geranyl-diphosphate diphosphate-lyase (cyclizing, gamma-terpinene-forming).^[1]^[2]^[3]^[4]^[5] This enzyme catalyses the following chemical reaction

geranyl diphosphate

\rightleftharpoons

gamma-terpinene + diphosphate

This enzyme is isolated from Thymus vulgaris (thyme), Citrus limon (lemon), Citrus unshiu (satsuma) and Origanum vulgare (oregano).

References

↑ Alonso, W.R. and Croteau, R. (1991). "Purification and characterization of the monoterpene cyclase γ-terpinene synthase from Thymus vulgaris". Arch. Biochem. Biophys. 286 (2): 511–517. doi:10.1016/0003-9861(91)90073-r. PMID 1897973.
↑ LaFever, R.E. and Croteau, R. (1993). "Hydride shifts in the biosynthesis of the p-menthane monoterpenes α-terpinene, γ-terpinene, and β-phellandrene". Arch. Biochem. Biophys. 301 (2): 361–366. doi:10.1006/abbi.1993.1156. PMID 8460944.
↑ Lücker, J., El Tamer, M.K., Schwab, W., Verstappen, F.W., van der Plas, L.H., Bouwmeester, H.J. and Verhoeven, H.A. (2000). "Monoterpene biosynthesis in lemon (Citrus limon). cDNA isolation and functional analysis of four monoterpene synthases". Eur. J. Biochem. 269: 3160–3171. doi:10.1046/j.1432-1033.2002.02985.x. PMID 12084056.
↑ Suzuki, Y., Sakai, H., Shimada, T., Omura, M., Kumazawa, S. and Nakayama, T. (2004). "Characterization of γ-terpinene synthase from Citrus unshiu (Satsuma mandarin)". BioFactors 21 (1-4): 79–82. doi:10.1002/biof.552210115. PMID 15630174.
↑ Crocoll, C., Asbach, J., Novak, J., Gershenzon, J. and Degenhardt, J. (2010). "Terpene synthases of oregano (Origanum vulgare L.) and their roles in the pathway and regulation of terpene biosynthesis". Plant Mol. Biol. 73 (6): 587–603. doi:10.1007/s11103-010-9636-1. PMID 20419468.

External links

Gamma-terpinene synthase at the US National Library of Medicine Medical Subject Headings (MeSH)

Carbon-oxygen lyases (EC 4.2) (primarily dehydratases)

4.2.1: Hydro-Lyases	Carbonic anhydrase Fumarase Aconitase Enolase Alpha Enolase 2 Enoyl-CoA hydratase/3-Hydroxyacyl ACP dehydrase Methylglutaconyl-CoA hydratase Tryptophan synthase Cystathionine beta synthase Porphobilinogen synthase 3-Isopropylmalate dehydratase Urocanase Uroporphyrinogen III synthase Nitrile hydratase

4.2.2: Acting on polysaccharides	Hyaluronate lyase

4.2.3: Acting on phosphates	Threonine synthase

4.2.99: Other	Carboxymethyloxysuccinate lyase

Enzymes

Activity	Active site Binding site Catalytic triad Oxyanion hole Enzyme promiscuity Catalytically perfect enzyme Coenzyme Cofactor Enzyme catalysis Enzyme kinetics Lineweaver–Burk plot Michaelis–Menten kinetics

Regulation	Allosteric regulation Cooperativity Enzyme inhibitor

Classification	EC number Enzyme superfamily Enzyme family List of enzymes

Types	EC1 Oxidoreductases(list) EC2 Transferases(list) EC3 Hydrolases(list) EC4 Lyases(list) EC5 Isomerases(list) EC6 Ligases(list)

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