Glycyl endopeptidase

Glycyl endopeptidase
Identifiers
EC number	3.4.22.25
CAS number	149719-24-4
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Search PMC articles PubMed articles NCBI proteins

Glycyl endopeptidase (EC 3.4.22.25, papaya peptidase B, papaya proteinase IV, glycine-specific proteinase, chymopapain, Papaya proteinase 4, PPIV, chymopapain M) is an enzyme.^{[1][2][3][4][5]} This enzyme catalyses the following chemical reaction

Preferential cleavage: Gly-, in proteins and small molecule substrates

This enzyme is isolated from the papaya plant, Carica papaya.

References

1. Polgár, L. (1981). "Isolation of highly active papaya peptidases A and B from commercial chymopapain". Biochim. Biophys. Acta 658: 262–269. doi:10.1016/0005-2744(81)90296-5. PMID 7018581.
2. Buttle, D.J., Kembhavi, A.A., Sharp, S.L., Shute, R.E., Rich, D.H. and Barrett, A.J. (1989). "Affinity purification of the novel cysteine proteinase papaya proteinase IV and papain from papaya latex". Biochem. J. 261: 469–476. PMID 2505761.
3. Ritonja, A., Buttle, D.J., Rawlings, N.D., Turk, V. and Barrett, A.J. (1989). "Papaya proteinase IV amino acid sequence". FEBS Lett. 258: 109–112. doi:10.1016/0014-5793(89)81627-8. PMID 2591528.
4. Buttle, D.J., Ritonja, A., Pearl, L.H., Turk, V. and Barrett, A.J. (1990). "Selective cleavage of glycyl bonds by papaya proteinase IV". FEBS Lett. 260: 195–197. doi:10.1016/0014-5793(90)80101-n. PMID 2404797.
5. Buttle, D.J., Ritonja, A., Dando, P.M., Abrahamson, M., Shaw, E.N., Wikstrom, P., Turk, V. and Barrett, A.J. (1990). "Interaction of papaya proteinase IV with inhibitors". FEBS Lett. 262: 58–60. doi:10.1016/0014-5793(90)80153-a. PMID 1690669.

External links

• Glycyl endopeptidase at the US National Library of Medicine Medical Subject Headings (MeSH)